Table 1. Selected examples of genes... | Rockefeller University Press

Table 1.

Selected examples of genes important for mast cell development

Gene	Mouse model	Phenotype	Reference
GATA2	GATA2ΔCF	Loss of mast cell phenotype in BMMCs	Ohmori et al., 2015
STAT5	STAT5A/B +/−	Deficiency of mast cells in all analyzed tissues	Shelburne et al., 2003
MITF	MITF −/− (tg/tg mice)	Deficiency of mast cells in peritoneum, mesentery, stomach, spleen	Morii et al., 2004
NDST2	NDST2 −/−	Decreased numbers of connective tissue mast cells and reduced mast cell proteases and histamine content	Forsberg et al., 1999
HDC	HDC −/− mice	Decreased numbers of peritoneal and mesenterial mast cells and decreased histamine content	Ohtsu et al., 2001
CPA3	CPA3 −/− mice	Immature peritoneal mast cells with reduced granular staining	Feyerabend et al., 2005
PI3K	p85α −/− and p110γ −/− DKO mice	Severe defects in mast cell development	Takayama et al., 2013
PI3K	p85α −/− mice	Mast cell deficiency in gastrointestinal and peritoneal mast cells	Fukao et al., 2002
AHR	AHR −/− mice	Reduction in skin, peritoneal cavity, and stomach mucosa–resident mast cells	Zhou et al., 2013
SRGN	SRGN −/− mice	Deficiency in granulated mast cells in peritoneum and ear	Åbrink et al., 2004
PLA2G3	PLA2G3 −/− mice	Irregularly shaped and immature tissue mast cells	Taketomi et al., 2013
Mac-1 (CD11b/CD18, CR3)	Mac-1 −/− mice	Decreased number of mast cells in peritoneum and dorsal epidermis	Rosenkranz et al., 1998
P38α	Mx-Cre⁺ P38α^F/F (P38α^−/−)	Decreased numbers of peritoneal and lung mast cells	Hu et al., 2012

Gene	Mouse model	Phenotype	Reference
GATA2	GATA2ΔCF	Loss of mast cell phenotype in BMMCs	Ohmori et al., 2015
STAT5	STAT5A/B +/−	Deficiency of mast cells in all analyzed tissues	Shelburne et al., 2003
MITF	MITF −/− (tg/tg mice)	Deficiency of mast cells in peritoneum, mesentery, stomach, spleen	Morii et al., 2004
NDST2	NDST2 −/−	Decreased numbers of connective tissue mast cells and reduced mast cell proteases and histamine content	Forsberg et al., 1999
HDC	HDC −/− mice	Decreased numbers of peritoneal and mesenterial mast cells and decreased histamine content	Ohtsu et al., 2001
CPA3	CPA3 −/− mice	Immature peritoneal mast cells with reduced granular staining	Feyerabend et al., 2005
PI3K	p85α −/− and p110γ −/− DKO mice	Severe defects in mast cell development	Takayama et al., 2013
PI3K	p85α −/− mice	Mast cell deficiency in gastrointestinal and peritoneal mast cells	Fukao et al., 2002
AHR	AHR −/− mice	Reduction in skin, peritoneal cavity, and stomach mucosa–resident mast cells	Zhou et al., 2013
SRGN	SRGN −/− mice	Deficiency in granulated mast cells in peritoneum and ear	Åbrink et al., 2004
PLA2G3	PLA2G3 −/− mice	Irregularly shaped and immature tissue mast cells	Taketomi et al., 2013
Mac-1 (CD11b/CD18, CR3)	Mac-1 −/− mice	Decreased number of mast cells in peritoneum and dorsal epidermis	Rosenkranz et al., 1998
P38α	Mx-Cre⁺ P38α^F/F (P38α^−/−)	Decreased numbers of peritoneal and lung mast cells	Hu et al., 2012