Table 1. Major drivers of myeloid... | Rockefeller University Press

Table 1.

Major drivers of myeloid recruitment and heterogeneity in solid tumors

	Mutation	Cancer cell secretory/gene expression profile	Tumor	Myeloid response	Reference
TP53	TP53^R175H	↑ CXCL1, CXCL5, and CCL2	PDAC	Activation NF-κB pathway Neutrophil and monocyte recruitment	Mahat et al. (2025)
	Trp53^−/−	↑ CCL2 and CSF-1	NSCLC and PDAC	Macrophage recruitment via CXCR3	Blagih et al. (2020)
	Trp53^−/−	↑ CCL2, IL-1, IL-17A, and G-CSF	Breast tumors	Recruitment of immNeus	Wellenstein et al. (2019)
PI3K	PI3KCA^H1047R	↑ Csf1, Ccl2, and Ccl7	CRC	Enhanced recruitment of immunosuppressive myeloid cells. ↑ CCR2, arginase, and IL-1β expression	Collins et al. (2022)
PTEN	Pten^-/-	↑ Il1a and Il1r1 ↑ Ifit1, Tnfaip2, Cxcl2, Cxcl13, and Cxcl15	PCa	Activation NF-κB pathway. Recruitment of neutrophils, monocytes, and macrophages	Jiang et al. (2025a)
KRAS	KRAS^G12D/KRAS^G12C	↑ IL-1α/β, IL-6, TNFα, CXCL1/2/5/8, and CCL2	PDAC, CRC, and NSCLC	NF-κB activation	Hamarsheh et al. (2020)
	Kras^G12D	↓ TGFA, TGFB, CXCL1, and CXCL2	NSCLC	Increased infiltration of F4/80 MPO⁺, complement genes, Mrc1, and Csf1r ↑ CCL2, IL-1β, and CCL4	Lasse-Opsahl et al. (2025)
	Kras^G12D	GM-CSF and lactate	CRC	Reprogrammed TAMs IL-10⁺, TGF-β⁺, and CCL17⁺	Liu et al. (2021)
LK1B	LKB1 loss	↑ IL-6, IL-8, and CXCL1/8	NSCLC	↑ Neutrophil recruitment ↓ Type II–IFN signaling	Skoulidis and Heymach (2019), Li et al. (2021), Compton et al. (2023), and Koyama et al. (2016)

	Mutation	Cancer cell secretory/gene expression profile	Tumor	Myeloid response	Reference
TP53	TP53^R175H	↑ CXCL1, CXCL5, and CCL2	PDAC	Activation NF-κB pathway Neutrophil and monocyte recruitment	Mahat et al. (2025)
	Trp53^−/−	↑ CCL2 and CSF-1	NSCLC and PDAC	Macrophage recruitment via CXCR3	Blagih et al. (2020)
	Trp53^−/−	↑ CCL2, IL-1, IL-17A, and G-CSF	Breast tumors	Recruitment of immNeus	Wellenstein et al. (2019)
PI3K	PI3KCA^H1047R	↑ Csf1, Ccl2, and Ccl7	CRC	Enhanced recruitment of immunosuppressive myeloid cells. ↑ CCR2, arginase, and IL-1β expression	Collins et al. (2022)
PTEN	Pten^-/-	↑ Il1a and Il1r1 ↑ Ifit1, Tnfaip2, Cxcl2, Cxcl13, and Cxcl15	PCa	Activation NF-κB pathway. Recruitment of neutrophils, monocytes, and macrophages	Jiang et al. (2025a)
KRAS	KRAS^G12D/KRAS^G12C	↑ IL-1α/β, IL-6, TNFα, CXCL1/2/5/8, and CCL2	PDAC, CRC, and NSCLC	NF-κB activation	Hamarsheh et al. (2020)
	Kras^G12D	↓ TGFA, TGFB, CXCL1, and CXCL2	NSCLC	Increased infiltration of F4/80 MPO⁺, complement genes, Mrc1, and Csf1r ↑ CCL2, IL-1β, and CCL4	Lasse-Opsahl et al. (2025)
	Kras^G12D	GM-CSF and lactate	CRC	Reprogrammed TAMs IL-10⁺, TGF-β⁺, and CCL17⁺	Liu et al. (2021)
LK1B	LKB1 loss	↑ IL-6, IL-8, and CXCL1/8	NSCLC	↑ Neutrophil recruitment ↓ Type II–IFN signaling	Skoulidis and Heymach (2019), Li et al. (2021), Compton et al. (2023), and Koyama et al. (2016)