Table 3. Literature review of reported... | Rockefeller University Press

Table 3.

Literature review of reported cases of CGD patients undergoing HSCT after an IMI diagnosis

Study (reference)	Age at the moment of HSCT	IMI	Localization	Outcome
(30)				Engraftment: Yes
N = 1	8 years	Aspergillosis with DP	Disseminated (lung, skin and muscular)	GVHD: No
N = 1	8 years	Aspergillosis with DP	Disseminated (lung, skin and muscular)	Cured of IMI and alive: Yes
(28)				Engraftment: Yes
N = 1	4 years	Aspergillosis with DP	Pneumonia and contiguous osteomyelitis	GVHD: grade III skin
N = 1	4 years	Aspergillosis with DP	Pneumonia and contiguous osteomyelitis	Cured and alive: Yes
(13)				Engraftment: 2/4
N = 4	MA: 15.5 years [14–16]	Four aspergillosis with DP	One disseminated infection including heart and bones involvement, two disseminated infections with lung and CNS involvement, one pneumonia	GVHD: 2/4
N = 4	MA: 15.5 years [14–16]	Four aspergillosis with DP		Cured and alive: 1/4^a
(13)				Engraftment: Yes
N = 1	20 years	S. apiospermum infection with DP	Disseminated (lung and paraspinal)	GVHD: No
N = 1	20 years	S. apiospermum infection with DP	Disseminated (lung and paraspinal)	Cured and alive: no^{^b}
(31)				Engraftment: Yes
N = 1	18 years	S. apiospermum infection with DP	Paraspinal abscess	GVHD: No
N = 1	18 years	S. apiospermum infection with DP	Paraspinal abscess	Cured and alive: No^{^c}
(32)				Engraftment: Yes
N = 1	8 years	Aspergillosis with DP	Disseminated (lung + vertebrae)	GVHD: grade III gut + liver
N = 1	8 years	Aspergillosis with DP	Disseminated (lung + vertebrae)	Cured and alive: Yes
(33)				Engraftment: Yes^{^d}
N = 1	3 years	Aspergillosis with DP	Disseminated (lung + CNS)	GVHD: grade II
N = 1	3 years	Aspergillosis with DP	Disseminated (lung + CNS)	Cured and alive: Yes
(34)				Engraftment: 7/9
N = 9	MA: 2 years [2–3]	Aspergillosis with CR	Lung	GVHD: 2/9
N = 9	MA: 2 years [2–3]	Aspergillosis with CR	Lung	Cured and alive: 6/9^{^e}
(35)			Two pneumonias	Engraftment: 2/3
N = 3	15, 17, and 21 years	Two aspergillosis with CR and one aspergillosis with DP	One disseminated infection (brain; kidney)	GVHD: 1/3 (grade 2 skin)
N = 3	15, 17, and 21 years	Two aspergillosis with CR and one aspergillosis with DP	One disseminated infection (brain; kidney)	Cured and alive: 2/3^{^f}
(36)				Engraftment: Yes
N = 1	6 years	Aspergillosis with CR	Pneumonia	GVHD: No
N = 1	6 years	Aspergillosis with CR	Pneumonia	Cured and alive: Yes
(37)				Engraftment: Yes
N = 1	13 years	Aspergillosis with CR	Sinusitis	GVHD: grade 2 liver
N = 1	13 years	Aspergillosis with CR	Sinusitis	Cured and alive: Yes
(38)				Engraftment: Yes
N = 1	8 years	Aspergillosis (no information about infection stage)	Pneumonia	GVHD: No
N = 1	8 years	Aspergillosis (no information about infection stage)	Pneumonia	Cured and alive: Yes
(39)				Engraftment: 2/2^{^g}
N = 2	13 and 5 years	Aspergillosis with DP	Pneumonia	GVHD: 1/2 (grade 2 skin)
N = 2	13 and 5 years	Aspergillosis with DP	Pneumonia	Cured and alive: 2/2
(40)				Engraftment: Yes^{^h}
N = 1	3 mo	Aspergillosis with DP	Pneumonia	GVHD: grade 2 skin
N = 1	3 mo	Aspergillosis with DP	Pneumonia	Cured and alive: Yes
(23)				Engraftment: 11/11
N = 11	MA: 14 years [13–16]	S. apiospermum infection with DP	Two disseminated infections (one bones + lung; one CNS + lung), nine pneumonias	GVHD: 1/11
N = 11	MA: 14 years [13–16]	S. apiospermum infection with DP		Cured and alive: 10/11^ⁱ
(29)				Engraftment: Yes
N = 1	12 years	Aspergillosis with DP	Pericarditis	GVHD: grade 2 GI
N = 1	12 years	Aspergillosis with DP	Pericarditis	Cured and alive: Yes
(29)				Engraftment: Yes
N = 1	26 years	Two aspergillosis with DP	Pneumonia with contiguous osteomyelitis	GVHD: grade 2 GI
N = 1	26 years	Two aspergillosis with DP	Pneumonia with contiguous osteomyelitis	Cured and alive: Yes
(41)				Engraftment: 2/2^{^j}
N = 2	1 and 11 years	Aspergillosis with CR	One disseminated infection (no information about localization)1	GVHD: 0
N = 2	1 and 11 years	Aspergillosis with CR		Cured and alive: 2/2
(42)				Engraftment: Yes
N = 1	5 years	Two scedosporiosis with SR^{^k} and four aspergillosis with SR^{^k}	Pneumonia	GVHD: grade 2 GI
N = 1	5 years		Pneumonia	Cured and alive: Yes
(43)				Engraftment: 13/13
N = 13	MA: 18 [5–25]	Seven aspergillosis with DP	Six pneumonias, five disseminated diseases, one spinal abscess, and one muscular abscess	GVHD: 4/13
N = 13	MA: 18 [5–25]	Seven aspergillosis with DP		Cured and alive: 10/13
This paper				Engraftment: 12/14
N = 14	MA: 15 years [10–30]	See Table 1	See Table 1	GVHD: 1/14
N = 14	MA: 15 years [10–30]	See Table 1	See Table 1	Cured and alive: 12/14

Study (reference)	Age at the moment of HSCT	IMI	Localization	Outcome
(30)				Engraftment: Yes
N = 1	8 years	Aspergillosis with DP	Disseminated (lung, skin and muscular)	GVHD: No
N = 1	8 years	Aspergillosis with DP	Disseminated (lung, skin and muscular)	Cured of IMI and alive: Yes
(28)				Engraftment: Yes
N = 1	4 years	Aspergillosis with DP	Pneumonia and contiguous osteomyelitis	GVHD: grade III skin
N = 1	4 years	Aspergillosis with DP	Pneumonia and contiguous osteomyelitis	Cured and alive: Yes
(13)				Engraftment: 2/4
N = 4	MA: 15.5 years [14–16]	Four aspergillosis with DP	One disseminated infection including heart and bones involvement, two disseminated infections with lung and CNS involvement, one pneumonia	GVHD: 2/4
N = 4	MA: 15.5 years [14–16]	Four aspergillosis with DP		Cured and alive: 1/4^a
(13)				Engraftment: Yes
N = 1	20 years	S. apiospermum infection with DP	Disseminated (lung and paraspinal)	GVHD: No
N = 1	20 years	S. apiospermum infection with DP	Disseminated (lung and paraspinal)	Cured and alive: no^{^b}
(31)				Engraftment: Yes
N = 1	18 years	S. apiospermum infection with DP	Paraspinal abscess	GVHD: No
N = 1	18 years	S. apiospermum infection with DP	Paraspinal abscess	Cured and alive: No^{^c}
(32)				Engraftment: Yes
N = 1	8 years	Aspergillosis with DP	Disseminated (lung + vertebrae)	GVHD: grade III gut + liver
N = 1	8 years	Aspergillosis with DP	Disseminated (lung + vertebrae)	Cured and alive: Yes
(33)				Engraftment: Yes^{^d}
N = 1	3 years	Aspergillosis with DP	Disseminated (lung + CNS)	GVHD: grade II
N = 1	3 years	Aspergillosis with DP	Disseminated (lung + CNS)	Cured and alive: Yes
(34)				Engraftment: 7/9
N = 9	MA: 2 years [2–3]	Aspergillosis with CR	Lung	GVHD: 2/9
N = 9	MA: 2 years [2–3]	Aspergillosis with CR	Lung	Cured and alive: 6/9^{^e}
(35)			Two pneumonias	Engraftment: 2/3
N = 3	15, 17, and 21 years	Two aspergillosis with CR and one aspergillosis with DP	One disseminated infection (brain; kidney)	GVHD: 1/3 (grade 2 skin)
N = 3	15, 17, and 21 years	Two aspergillosis with CR and one aspergillosis with DP	One disseminated infection (brain; kidney)	Cured and alive: 2/3^{^f}
(36)				Engraftment: Yes
N = 1	6 years	Aspergillosis with CR	Pneumonia	GVHD: No
N = 1	6 years	Aspergillosis with CR	Pneumonia	Cured and alive: Yes
(37)				Engraftment: Yes
N = 1	13 years	Aspergillosis with CR	Sinusitis	GVHD: grade 2 liver
N = 1	13 years	Aspergillosis with CR	Sinusitis	Cured and alive: Yes
(38)				Engraftment: Yes
N = 1	8 years	Aspergillosis (no information about infection stage)	Pneumonia	GVHD: No
N = 1	8 years	Aspergillosis (no information about infection stage)	Pneumonia	Cured and alive: Yes
(39)				Engraftment: 2/2^{^g}
N = 2	13 and 5 years	Aspergillosis with DP	Pneumonia	GVHD: 1/2 (grade 2 skin)
N = 2	13 and 5 years	Aspergillosis with DP	Pneumonia	Cured and alive: 2/2
(40)				Engraftment: Yes^{^h}
N = 1	3 mo	Aspergillosis with DP	Pneumonia	GVHD: grade 2 skin
N = 1	3 mo	Aspergillosis with DP	Pneumonia	Cured and alive: Yes
(23)				Engraftment: 11/11
N = 11	MA: 14 years [13–16]	S. apiospermum infection with DP	Two disseminated infections (one bones + lung; one CNS + lung), nine pneumonias	GVHD: 1/11
N = 11	MA: 14 years [13–16]	S. apiospermum infection with DP		Cured and alive: 10/11^ⁱ
(29)				Engraftment: Yes
N = 1	12 years	Aspergillosis with DP	Pericarditis	GVHD: grade 2 GI
N = 1	12 years	Aspergillosis with DP	Pericarditis	Cured and alive: Yes
(29)				Engraftment: Yes
N = 1	26 years	Two aspergillosis with DP	Pneumonia with contiguous osteomyelitis	GVHD: grade 2 GI
N = 1	26 years	Two aspergillosis with DP	Pneumonia with contiguous osteomyelitis	Cured and alive: Yes
(41)				Engraftment: 2/2^{^j}
N = 2	1 and 11 years	Aspergillosis with CR	One disseminated infection (no information about localization)1	GVHD: 0
N = 2	1 and 11 years	Aspergillosis with CR		Cured and alive: 2/2
(42)				Engraftment: Yes
N = 1	5 years	Two scedosporiosis with SR^{^k} and four aspergillosis with SR^{^k}	Pneumonia	GVHD: grade 2 GI
N = 1	5 years		Pneumonia	Cured and alive: Yes
(43)				Engraftment: 13/13
N = 13	MA: 18 [5–25]	Seven aspergillosis with DP	Six pneumonias, five disseminated diseases, one spinal abscess, and one muscular abscess	GVHD: 4/13
N = 13	MA: 18 [5–25]	Seven aspergillosis with DP		Cured and alive: 10/13
This paper				Engraftment: 12/14
N = 14	MA: 15 years [10–30]	See Table 1	See Table 1	GVHD: 1/14
N = 14	MA: 15 years [10–30]	See Table 1	See Table 1	Cured and alive: 12/14

N = number of patients. CGD, chronic granulomatous disease; MA, median age; GI, gastrointestinal; CNS, central nervous system; BM, bone marrow.

The causes of death were progression of aspergillosis before engraftment in two patients and a massive hemorrhage in one patient.

The patient died from an uncontrolled hemorrhage through an eroded carotid artery.

The patient succumbed to a complication of tracheostomy 73 days after transplantation.

The patient had an HSCT failure following a first HSCT with reduced toxicity conditioning.

One patient died from ARDS, another from systemic BK virus infection, the third from complications of chronic GVHD.

One patient died 1 day prior to transplantation from multiorgan failure secondary to disseminated A. nidulans infection.

One patient had HSCT failure following a first HSCT with myeloablative conditioning.

The patient experienced an allograft rejection following a cord blood transplantation from an unrelated donor before her last HSCT.

One patient with IPA died from a steroid-refractory acute GVHD of grade III–IV at day 125 after HSCT.

One of the patient received a boost with a BM donor 37 days after HSCT.

According to the definitions of the study published by Klin et al, the disease was stable if the patient had no clinical symptoms related to the disease, and pretransplant radiology revealed no changes to suggest progression at day 0.

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