Demographics and clinical characteristics of study participants
| Characteristic . | Total (n = 28) . | Cont IgGRT (n = 17) . | No IgGRT (n = 11) . | P value . |
|---|---|---|---|---|
| Sex, male, n (%) | 10 (36) | 5 (29) | 5 (45) | ns |
| Age, years, median (range) | 59 (32–75) | 58 (32–71) | 60 (43–75) | ns |
| Years since diagnosis, median (range) | 2 (0–30) | 1 (0–30) | 3 (1–21) | ns |
| scIgGRT, n (%) | 27 (96) | 16 (94) | 11 (100) | ns |
| Dose IgGRT, mg/kg/wk, median (range) | 103 (50–174) | 101 (92–174) | 103 (50–120) | ns |
| Ever vaccinateda, n (%) | 13 (46) | 8 (41) | 5 (45) | ns |
| Infections with IgGRT, median (range) | 2 (0–13) | 2 (0–8) | 2 (0–13) | ns |
| Infections without IgGRT, median (range) | 3 (0–7) | 3 (0–7) | 2 (0–6) | ns |
| Months without IgGRT, median (range) | 18 (6–19) | 17 (6–18) | 18 (18–19) | – |
| Chronic lung diseaseb, n (%) | 12 (43) | 7 (41) | 5 (45) | ns |
| Bronchiectasis, n (%) | 8 (29) | 4 (24) | 4 (36) | ns |
| Lung function %c, median (range) | 91 (40–114) | 90 (40–114) | 91 (50–107) | ns |
| Autoimmunity, n (%) | 15 (54) | 10 (59) | 5 (45) | ns |
| Systemic corticosteroidsd | 6 (21) | 1 (6.0) | 5 (45) | 0.022 |
| Immune suppression | 0 | 0 | 0 | – |
| Subnormal total IgG, n (%) | 15 (54) | 11 (65) | 4 (36) | ns |
| Subnormal IgA, n (%) | 6 (21) | 5 (29) | 1 (9.0) | ns |
| Subnormal IgG1 | 5 (18) | 5 (29) | 0 | ns |
| Subnormal IgG2 | 11 (39) | 9 (50) | 2 (18) | ns |
| Subnormal IgG3 | 18 (64) | 11 (65) | 7 (64) | ns |
| Complexe IgGSD, n (%) | 9 (33) | 8 (47) | 1 (9.0) | 0.047 |
| MBL deficiency, n (%) | 6 (21) | 3 (18) | 3 (27) | ns |
| IgM, g/L, median (range) | 0.82 (0.07–3.0) | 0.81 (0.07–2.3) | 0.84 (0.3–3.0) | 0.27–2.1 |
| IgG, g/L, median (range) | 6.2 (2.1–12) | 5.4 (2.2–11.9) | 8.2 (4.9–11.3) | 6.7–15 |
| IgA, g/L, median (range) | 1.5 (0.09–3.8) | 1.5 (0.09–2.8) | 1.7 (0.84–3.8) | 0.88–4.5 |
| IgG1, g/L, median (range) | 3.8 (1.4–10) | 3.6 (1.4–10.3) | 4.1 (3.3–9.0) | 2.8–8.0 |
| IgG2, g/L, median (range) | 1.6 (0–4.5) | 1.0 (0–4.5) | 2.4 (0.55–4.2) | 1.15–5.7 |
| IgG3, g/L, median (range) | 0.16 (0–1.0) | 0.12 (0–0.9) | 0.2 (0–0.5) | 0.24–1.3 |
| Characteristic . | Total (n = 28) . | Cont IgGRT (n = 17) . | No IgGRT (n = 11) . | P value . |
|---|---|---|---|---|
| Sex, male, n (%) | 10 (36) | 5 (29) | 5 (45) | ns |
| Age, years, median (range) | 59 (32–75) | 58 (32–71) | 60 (43–75) | ns |
| Years since diagnosis, median (range) | 2 (0–30) | 1 (0–30) | 3 (1–21) | ns |
| scIgGRT, n (%) | 27 (96) | 16 (94) | 11 (100) | ns |
| Dose IgGRT, mg/kg/wk, median (range) | 103 (50–174) | 101 (92–174) | 103 (50–120) | ns |
| Ever vaccinateda, n (%) | 13 (46) | 8 (41) | 5 (45) | ns |
| Infections with IgGRT, median (range) | 2 (0–13) | 2 (0–8) | 2 (0–13) | ns |
| Infections without IgGRT, median (range) | 3 (0–7) | 3 (0–7) | 2 (0–6) | ns |
| Months without IgGRT, median (range) | 18 (6–19) | 17 (6–18) | 18 (18–19) | – |
| Chronic lung diseaseb, n (%) | 12 (43) | 7 (41) | 5 (45) | ns |
| Bronchiectasis, n (%) | 8 (29) | 4 (24) | 4 (36) | ns |
| Lung function %c, median (range) | 91 (40–114) | 90 (40–114) | 91 (50–107) | ns |
| Autoimmunity, n (%) | 15 (54) | 10 (59) | 5 (45) | ns |
| Systemic corticosteroidsd | 6 (21) | 1 (6.0) | 5 (45) | 0.022 |
| Immune suppression | 0 | 0 | 0 | – |
| Subnormal total IgG, n (%) | 15 (54) | 11 (65) | 4 (36) | ns |
| Subnormal IgA, n (%) | 6 (21) | 5 (29) | 1 (9.0) | ns |
| Subnormal IgG1 | 5 (18) | 5 (29) | 0 | ns |
| Subnormal IgG2 | 11 (39) | 9 (50) | 2 (18) | ns |
| Subnormal IgG3 | 18 (64) | 11 (65) | 7 (64) | ns |
| Complexe IgGSD, n (%) | 9 (33) | 8 (47) | 1 (9.0) | 0.047 |
| MBL deficiency, n (%) | 6 (21) | 3 (18) | 3 (27) | ns |
| IgM, g/L, median (range) | 0.82 (0.07–3.0) | 0.81 (0.07–2.3) | 0.84 (0.3–3.0) | 0.27–2.1 |
| IgG, g/L, median (range) | 6.2 (2.1–12) | 5.4 (2.2–11.9) | 8.2 (4.9–11.3) | 6.7–15 |
| IgA, g/L, median (range) | 1.5 (0.09–3.8) | 1.5 (0.09–2.8) | 1.7 (0.84–3.8) | 0.88–4.5 |
| IgG1, g/L, median (range) | 3.8 (1.4–10) | 3.6 (1.4–10.3) | 4.1 (3.3–9.0) | 2.8–8.0 |
| IgG2, g/L, median (range) | 1.6 (0–4.5) | 1.0 (0–4.5) | 2.4 (0.55–4.2) | 1.15–5.7 |
| IgG3, g/L, median (range) | 0.16 (0–1.0) | 0.12 (0–0.9) | 0.2 (0–0.5) | 0.24–1.3 |