The table reports mean ± SEM current density measurements (pA/pF) in different conditions from experiments shown in Figs. 4, 5, and 6. Indicated are the numbers of cells (n). As indicated for each set of data, statistical analysis was performed using the generalized linear model (Gamma) or the linear model (normal) according to the criteria explained in Materials and methods. Details of the statistical analysis and the resulting significance of data comparisons are outlined for all experiments in Table S2. Data were obtained from cells expressing wild-type or mutant hHCN4 channels under control conditions or after treatment. In each experimental set, cells from the same day-matched batch were transfected with either wild-type or mutant channels, then divided into two groups, one used as control and the other exposed to AICAR.