Overview of patients with idiopathic T cell lymphopenia identified from TREC-based NBS
| ID . | Referral . | T cells, per µl blood (% naive)a . | Genetic testing performed . | Infections . | Prophylactic treatment . | Other comorbidity . | Follow-up timeb . | Follow-up ongoing . |
|---|---|---|---|---|---|---|---|---|
| ITCL-1 | Non-urgent (pilot) | CD3+: 980 CD4+: 680 (82.1%) CD8+: 310 (98.3%) | WES with SCID and PID gene panel filter | Viral upper respiratory tract | Antibacterial (for 2.2 years after referral) | No | >5.5 years | Yes |
| ITCL-2 | Non-urgent (pilot) | CD3+: 1,260 CD4+: 910 (ND) CD8+: 350 (ND) | WES with SCID gene panel filter | No | No | No | 1 year | No |
| ITCL-3 | Non-urgent (pilot) | CD3+: 1,020 CD4+: 590 (ND) CD8+: 450 (ND) | WES with SCID gene panel filter | No | No | No | 1 year | No |
| ITCL-4 | Non-urgent (pilot) | CD3+: 1160 CD4+: 830 (84.6%) CD8+: 330 (98.1%) | WES with SCID gene panel filter | No | No | No | 7 mo | No |
| ITCL-5 | Non-urgent (pilot) | CD3+: 1,350 CD4+: 780 (81.7%) CD8+: 530 (97.9%) | WES with SCID and PID gene panel filter | No | No | Extreme prematurity (<28 wk) | 1.5 years | No |
| ITCL-6 | Non-urgent | CD3+: 630 CD4+: 430 (70.2%) CD8+: 140 (67.1%) | WES with SCID gene panel filter | Viral upper respiratory tract and recurrent otitis | No | No | >3.5 years | Yes |
| ITCL-7 | Non-urgent | CD3+: 1,410 CD4+: 1,260 (80.8%) CD8+: 150 (96%) | WES with SCID and PID gene panel filter, SNP array, and WGS | No | Antibacterial (for 6 mo after referral), antifungal (for 2 mo after referral) | Okur-Chung syndrome | >2.5 years | No |
| ITCL-8 | Non-urgent | CD3+: 932 CD4+: 618 (59.2%) CD8+: 213 (81.7%) | WES with PID gene panel filter | No | No | No | >3.25 years | No |
| ITCL-9 | Urgent | CD3+: 850 CD4+: 620 (80.6%) CD8+: 210 (63.8%) | WES with SCID and PID gene panel filter and SNP array | No | Antibacterial (started 1 month after referral, still ongoing) | No | >2 years | Yes |
| ITCL-10 | Non-urgent | CD3+: 1,212 CD4+: 876 (59.8%) CD8+: 312 (94.2%) | WES with PID gene panel filter | No | No | Hiatal hernia | 2 years | No |
| ITCL-11 | Non-urgent | CD3+: 1,262 CD4+: 933 (63.6%) CD8+: 295 (86.1%) | WES with SCID and PID gene panel filter | No | No | No | >1.75 years | Yes |
| ITCL-12 | Urgent | CD3+: 1,090 CD4+: 790 (74.9%) CD8+: 280 (83.9%) | WES with SCID gene panel filter | No | No | No | >4 mo | Yes |
| ID . | Referral . | T cells, per µl blood (% naive)a . | Genetic testing performed . | Infections . | Prophylactic treatment . | Other comorbidity . | Follow-up timeb . | Follow-up ongoing . |
|---|---|---|---|---|---|---|---|---|
| ITCL-1 | Non-urgent (pilot) | CD3+: 980 CD4+: 680 (82.1%) CD8+: 310 (98.3%) | WES with SCID and PID gene panel filter | Viral upper respiratory tract | Antibacterial (for 2.2 years after referral) | No | >5.5 years | Yes |
| ITCL-2 | Non-urgent (pilot) | CD3+: 1,260 CD4+: 910 (ND) CD8+: 350 (ND) | WES with SCID gene panel filter | No | No | No | 1 year | No |
| ITCL-3 | Non-urgent (pilot) | CD3+: 1,020 CD4+: 590 (ND) CD8+: 450 (ND) | WES with SCID gene panel filter | No | No | No | 1 year | No |
| ITCL-4 | Non-urgent (pilot) | CD3+: 1160 CD4+: 830 (84.6%) CD8+: 330 (98.1%) | WES with SCID gene panel filter | No | No | No | 7 mo | No |
| ITCL-5 | Non-urgent (pilot) | CD3+: 1,350 CD4+: 780 (81.7%) CD8+: 530 (97.9%) | WES with SCID and PID gene panel filter | No | No | Extreme prematurity (<28 wk) | 1.5 years | No |
| ITCL-6 | Non-urgent | CD3+: 630 CD4+: 430 (70.2%) CD8+: 140 (67.1%) | WES with SCID gene panel filter | Viral upper respiratory tract and recurrent otitis | No | No | >3.5 years | Yes |
| ITCL-7 | Non-urgent | CD3+: 1,410 CD4+: 1,260 (80.8%) CD8+: 150 (96%) | WES with SCID and PID gene panel filter, SNP array, and WGS | No | Antibacterial (for 6 mo after referral), antifungal (for 2 mo after referral) | Okur-Chung syndrome | >2.5 years | No |
| ITCL-8 | Non-urgent | CD3+: 932 CD4+: 618 (59.2%) CD8+: 213 (81.7%) | WES with PID gene panel filter | No | No | No | >3.25 years | No |
| ITCL-9 | Urgent | CD3+: 850 CD4+: 620 (80.6%) CD8+: 210 (63.8%) | WES with SCID and PID gene panel filter and SNP array | No | Antibacterial (started 1 month after referral, still ongoing) | No | >2 years | Yes |
| ITCL-10 | Non-urgent | CD3+: 1,212 CD4+: 876 (59.8%) CD8+: 312 (94.2%) | WES with PID gene panel filter | No | No | Hiatal hernia | 2 years | No |
| ITCL-11 | Non-urgent | CD3+: 1,262 CD4+: 933 (63.6%) CD8+: 295 (86.1%) | WES with SCID and PID gene panel filter | No | No | No | >1.75 years | Yes |
| ITCL-12 | Urgent | CD3+: 1,090 CD4+: 790 (74.9%) CD8+: 280 (83.9%) | WES with SCID gene panel filter | No | No | No | >4 mo | Yes |