Table 3. Demographics and clinical... | Rockefeller University Press

Table 3.

Demographics and clinical history of IFN-I autoAbs-positive individuals

	Cohort	Age (years)	Sex	HIV treatment status	CD4⁺ count (cells/μl)	IFN-I neutralized	Collection year	Infection history	Prior IFN-α treatment
P1	Danish	67	Male	ART	550	IFN-ω 1 ng/ml IFN-ω 200 pg/ml	2009	• Rectal cancer (1992) • HCV co-infection • Streptococcus bovis bacteremia (2013) • Deceased: May 2020 • Cause of death: HCC	Yes
P2	Danish	29	Female	ART	310	IFN-ω 1 ng/ml IFN-ω 200 pg/ml	2011	• Cervical HPV infection developing into LSIL (2012) and carcinoma in situ (2014) • Hospitalized with pneumococcal pneumonia (2016)	No
P3	Danish	52	Female	ART	830	IFN-ω 200 pg/ml	2019	• HCV co-infection (chronic since 2002^{^a})	Yes
P4	American	56	Male	Naive	741	IFN-ω 1 ng/ml IFN-ω 200 pg/ml	2009	• Frequently hospitalized due to viremic episodes and community acquired pneumonia • History of HSV-2 infection (before 2009) • Episodes of disseminated VZV, RSV, parainfluenza, and mild COVID-19 infections (after 2009)	No
P5	American	28	Male	Naive	408	IFN-ω 1 ng/ml IFN-ω 200 pg/ml	2018	• History of several episodes with STIs • Documented HSV-2 outbreak in 2018 • Diagnosed with MPox (after 2018)	No

	Cohort	Age (years)	Sex	HIV treatment status	CD4⁺ count (cells/μl)	IFN-I neutralized	Collection year	Infection history	Prior IFN-α treatment
P1	Danish	67	Male	ART	550	IFN-ω 1 ng/mlIFN-ω 200 pg/ml	2009	• Rectal cancer (1992)• HCV co-infection• Streptococcus bovis bacteremia (2013)• Deceased: May 2020• Cause of death: HCC	Yes
P2	Danish	29	Female	ART	310	IFN-ω 1 ng/mlIFN-ω 200 pg/ml	2011	• Cervical HPV infection developing into LSIL (2012) and carcinoma in situ (2014)• Hospitalized with pneumococcal pneumonia (2016)	No
P3	Danish	52	Female	ART	830	IFN-ω 200 pg/ml	2019	• HCV co-infection (chronic since 2002^a)	Yes
P4	American	56	Male	Naive	741	IFN-ω 1 ng/mlIFN-ω 200 pg/ml	2009	• Frequently hospitalized due to viremic episodes and community acquired pneumonia• History of HSV-2 infection (before 2009)• Episodes of disseminated VZV, RSV, parainfluenza, and mild COVID-19 infections (after 2009)	No
P5	American	28	Male	Naive	408	IFN-ω 1 ng/mlIFN-ω 200 pg/ml	2018	• History of several episodes with STIs• Documented HSV-2 outbreak in 2018• Diagnosed with MPox (after 2018)	No

IFN, interferon; ART, antiretroviral therapy; HCV, hepatitis C virus; HCC, hepatocellular carcinoma; HPV, human papillomavirus; LSIL, low-grade squamous intraepithelial lesion; HSV-2, herpes simplex virus type 2; VZV, varicella-zoster virus; RSV, respiratory syncytial virus; STI, sexually transmitted infection

Chronic HSV infection cleared after IFN-α treatment.

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