Biological features of MIS-A patients
| . | MIS-A 1 . | MIS-A 2 . | MIS-A 3 . | MIS-A 4 . | MIS-A 5 . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day of hospitalization | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| Hemoglobin level, mmol/L NR: 8.3–10.5 | 9.4 | 8.3 | 7.3 | 9.2 | 9.3 | 8.3 | 8.0 | 7.9 | 7.9 | 7.0 | 5.4 | 4.4 | - | 8.1 | 7.6 |
| Leukocyte count, × 109 cells/L NR: 3.5–8.8 | 19.1 | 16.9 | 14.8 | 13.4 | 13.4 | 12.0 | 7.2 | 10.9 | 19.3 | 9.5 | 6.3 | 7.9 | 5.7 | 12.1 | 13.8 |
| Platelet count, × 109 cells/L NR: 145–390 | 282 | 307 | 290 | 219 | 188 | 160 | 198 | 186 | 246 | 224 | 157 | 231 | 54 | 46 | 35 |
| Plasma creatinine, µmol/L NR: 60–105 | 135 | 160 | 140 | 91 | 108 | 82 | 67 | 67 | 68 | 59 | 51 | 45 | 59 | 159 | 205 |
| C-reactive protein, mg/L NV <10 | 260 | 230 | 200 | 60 | 86 | 110 | 299 | 376 | 410 | 299 | 284 | 286 | 342.8 | 414.1 | 407.2 |
| Ferritin level, µg/L NR: 12–300 | - | >2,000 | - | - | - | - | - | - | 734 | 233 | 225 | 231 | - | - | 449 |
| Plasma lactate, mmol/L NR: 0.7–2.1 | 2.0 | 2.2 | 3.0 | 1.6 | 0.7 | 0.6 | 24 | 27 | 27 | 1.2 | - | - | - | - | - |
| D-dimer, FEU/L NV <0.5 | 2.7 | 9.9 | 12 | - | 0.42 | - | - | - | 713 | - | 2.1 | 2.0 | >20 | 12.2 | 7.9 |
| Alanine aminotransferase, U/L NR: 10–70 | 199 | 2,110 | 5,080 | 54 | 53 | - | - | - | 672 | 16 | 16 | 38 | 51 | 56 | 61 |
| Brain-type natriuretic peptide, pmol/L NV <10.1 | - | 1,830 | - | - | - | - | - | - | 216 | - | 6,753 | - | - | - | 8,260 |
| Troponin T, ng/L NV <14 | - | 483 | - | - | - | - | - | - | - | 2,253 | 998 | 300 | - | - | 76 |
| . | MIS-A 1 . | MIS-A 2 . | MIS-A 3 . | MIS-A 4 . | MIS-A 5 . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day of hospitalization | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| Hemoglobin level, mmol/L NR: 8.3–10.5 | 9.4 | 8.3 | 7.3 | 9.2 | 9.3 | 8.3 | 8.0 | 7.9 | 7.9 | 7.0 | 5.4 | 4.4 | - | 8.1 | 7.6 |
| Leukocyte count, × 109 cells/L NR: 3.5–8.8 | 19.1 | 16.9 | 14.8 | 13.4 | 13.4 | 12.0 | 7.2 | 10.9 | 19.3 | 9.5 | 6.3 | 7.9 | 5.7 | 12.1 | 13.8 |
| Platelet count, × 109 cells/L NR: 145–390 | 282 | 307 | 290 | 219 | 188 | 160 | 198 | 186 | 246 | 224 | 157 | 231 | 54 | 46 | 35 |
| Plasma creatinine, µmol/L NR: 60–105 | 135 | 160 | 140 | 91 | 108 | 82 | 67 | 67 | 68 | 59 | 51 | 45 | 59 | 159 | 205 |
| C-reactive protein, mg/L NV <10 | 260 | 230 | 200 | 60 | 86 | 110 | 299 | 376 | 410 | 299 | 284 | 286 | 342.8 | 414.1 | 407.2 |
| Ferritin level, µg/L NR: 12–300 | - | >2,000 | - | - | - | - | - | - | 734 | 233 | 225 | 231 | - | - | 449 |
| Plasma lactate, mmol/L NR: 0.7–2.1 | 2.0 | 2.2 | 3.0 | 1.6 | 0.7 | 0.6 | 24 | 27 | 27 | 1.2 | - | - | - | - | - |
| D-dimer, FEU/L NV <0.5 | 2.7 | 9.9 | 12 | - | 0.42 | - | - | - | 713 | - | 2.1 | 2.0 | >20 | 12.2 | 7.9 |
| Alanine aminotransferase, U/L NR: 10–70 | 199 | 2,110 | 5,080 | 54 | 53 | - | - | - | 672 | 16 | 16 | 38 | 51 | 56 | 61 |
| Brain-type natriuretic peptide, pmol/L NV <10.1 | - | 1,830 | - | - | - | - | - | - | 216 | - | 6,753 | - | - | - | 8,260 |
| Troponin T, ng/L NV <14 | - | 483 | - | - | - | - | - | - | - | 2,253 | 998 | 300 | - | - | 76 |
| . | MIS-A 6 . | MIS-A 7 . | MIS-A 8 . | MIS-A 9 . | MIS-A 10 . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day of hospitalization | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| Hemoglobin level, g/dL NR: 13–17.5 | 10.3 | 8.2 | 8.1 | 12.3 | 11.8 | 11.4 | 10.3 | 9.1 | 8.1 | 12.3 | 11.4 | 10.7 | 12.0 | 9.0 | 8.1 |
| Leukocyte count, × 109 cells/L NR: 4.0–10.0 | 37.7 | 30.6 | 24.4 | 7.2 | 5.2 | 6.8 | 25.6 | 25.9 | 13.7 | 11.8 | 20.7 | 20.8 | 27.7 | 40.5 | 36.7 |
| Lymphocytes count, 109 cells/L NR: 1.5–4.00 | 0.8 | 1.0 | 0.5 | 1.7 | 0.6 | 0.7 | 0.8 | 1.3 | 0.6 | 0.5 | - | - | 1.3 | - | 1.2 |
| Neutrophils count, 109 cells/L NR: 2.00–7.50 | 36.6 | 28.4 | 23.2 | 4.66 | 4.28 | 5.7 | 23.8 | 24.1 | 12.6 | 10.7 | - | - | 24.9 | - | 34.6 |
| Platelet count, × 109 cells/L NR: 150-400 | 138 | 157 | 148 | 264 | 278 | 394 | 212 | 166 | 66 | 177 | 274 | 266 | 184 | 75 | 64 |
| Plasma creatinine, µmol/L NR: 59–104 | 255 | 228 | 193 | 92 | 82 | 70 | 401 | 312 | 224 | 58 | 49 | 61 | - | 727 | 336 |
| C-reactive protein, mg/L NV <5 | 320 | 316 | - | - | - | 64.5 | 86.9 | 175 | - | 353 | - | - | 328 | 314 | 328 |
| Ferritin level, µg/L NR: 6–34 | - | | | - | - | - | 309 | - | - | - | - | - | - | - | - |
| Plasma lactate, mmol/L NR: 0.5–1 | 5.4 | 3.8 | 2.1 | 1.3 | 2.0 | 1.3 | 7.8 | 5.6 | 1.3 | 1.9 | 1.1 | 2.5 | 3.2 | 1.9 | 0.9 |
| D-dimer, ng/ml | - | - | - | - | - | - | - | - | - | 990 | - | - | - | - | - |
| Alanine aminotransferase, U/L NR: 16–35 | 135 | 130 | 146 | 394 | 362 | 333 | 124 | 129 | 119 | 124 | - | 86 | 210 | 89 | 82 |
| Brain-type natriuretic peptide, ng/ml | >35,000 | >35,000 | - | 5,819 | 4,640 | - | >35,000 | 19,031 | 8,199 | 5,623 | 15,575 | >35,000 | >35,000 | >35,000 | 24,306 |
| Troponin T, ng/L | 622 | 793 | - | 2,132 | - | 400 | 150 | 119 | 80.6 | 155 | 212 | 231 | 413 | 1,399 | 380 |
| . | MIS-A 6 . | MIS-A 7 . | MIS-A 8 . | MIS-A 9 . | MIS-A 10 . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day of hospitalization | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| Hemoglobin level, g/dL NR: 13–17.5 | 10.3 | 8.2 | 8.1 | 12.3 | 11.8 | 11.4 | 10.3 | 9.1 | 8.1 | 12.3 | 11.4 | 10.7 | 12.0 | 9.0 | 8.1 |
| Leukocyte count, × 109 cells/L NR: 4.0–10.0 | 37.7 | 30.6 | 24.4 | 7.2 | 5.2 | 6.8 | 25.6 | 25.9 | 13.7 | 11.8 | 20.7 | 20.8 | 27.7 | 40.5 | 36.7 |
| Lymphocytes count, 109 cells/L NR: 1.5–4.00 | 0.8 | 1.0 | 0.5 | 1.7 | 0.6 | 0.7 | 0.8 | 1.3 | 0.6 | 0.5 | - | - | 1.3 | - | 1.2 |
| Neutrophils count, 109 cells/L NR: 2.00–7.50 | 36.6 | 28.4 | 23.2 | 4.66 | 4.28 | 5.7 | 23.8 | 24.1 | 12.6 | 10.7 | - | - | 24.9 | - | 34.6 |
| Platelet count, × 109 cells/L NR: 150-400 | 138 | 157 | 148 | 264 | 278 | 394 | 212 | 166 | 66 | 177 | 274 | 266 | 184 | 75 | 64 |
| Plasma creatinine, µmol/L NR: 59–104 | 255 | 228 | 193 | 92 | 82 | 70 | 401 | 312 | 224 | 58 | 49 | 61 | - | 727 | 336 |
| C-reactive protein, mg/L NV <5 | 320 | 316 | - | - | - | 64.5 | 86.9 | 175 | - | 353 | - | - | 328 | 314 | 328 |
| Ferritin level, µg/L NR: 6–34 | - | | | - | - | - | 309 | - | - | - | - | - | - | - | - |
| Plasma lactate, mmol/L NR: 0.5–1 | 5.4 | 3.8 | 2.1 | 1.3 | 2.0 | 1.3 | 7.8 | 5.6 | 1.3 | 1.9 | 1.1 | 2.5 | 3.2 | 1.9 | 0.9 |
| D-dimer, ng/ml | - | - | - | - | - | - | - | - | - | 990 | - | - | - | - | - |
| Alanine aminotransferase, U/L NR: 16–35 | 135 | 130 | 146 | 394 | 362 | 333 | 124 | 129 | 119 | 124 | - | 86 | 210 | 89 | 82 |
| Brain-type natriuretic peptide, ng/ml | >35,000 | >35,000 | - | 5,819 | 4,640 | - | >35,000 | 19,031 | 8,199 | 5,623 | 15,575 | >35,000 | >35,000 | >35,000 | 24,306 |
| Troponin T, ng/L | 622 | 793 | - | 2,132 | - | 400 | 150 | 119 | 80.6 | 155 | 212 | 231 | 413 | 1,399 | 380 |
| . | MIS-A 11 . | MIS-A 12 . | MIS-A 13 . | MIS-A 14 . | MIS-A 15 . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day of hospitalization | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| Hemoglobin level, g/dL NR: 13–17.5 | 9.9 | 7.8 | 8.2 | 9.3 | 9.5 | 8.8 | 10.8 | 10.6 | 9.5 | 10 | 8.7 | 7.3 | 13.5 | 7.6 | 7.1 |
| Leukocyte count, × 109 cells/L NR: 4.0–10.0 | 18.9 | 9.2 | 7.4 | 31.9 | 24.0 | 23.3 | 19.5 | 29.3 | 25.2 | 25.3 | 24.1 | 41.4 | 9.5 | 15.0 | 27.2 |
| Lymphocytes count, 109 cells/L NR: 1.5–4.00 | 1.0 | 1.2 | 0.9 | 9.0 | - | - | 5.7 | 5.0 | - | 2.8 | - | 3.7 | 1.9 | - | - |
| Neutrophils count, 109 cells/L NR: 2.00–7.50 | 17.3 | 7.4 | 5.9 | 28.7 | - | - | 17.6 | 26.6 | - | 22.3 | - | 36.0 | 10.5 | - | - |
| Platelet count, × 109 cells/L NR: 150-400 | 193 | 221 | 279 | 195 | 233 | 268 | 244 | 303 | 345 | 198 | 152 | 192 | 125 | 145 | 182 |
| Plasma creatinine, µmol/L NR: 59–104 | 55 | 52 | 50 | 549 | 473 | 436 | 63 | 65 | 54 | 234 | 115 | 70 | 103 | 86 | 81 |
| C-reactive protein, mg/L NV <5 | 142 | - | 41 | 450 | - | - | 263 | 316 | - | 411 | - | - | 311 | - | - |
| Ferritin level, µg/L NR: 6–34 | - | - | - | - | - | - | - | - | - | - | - | 2,166 | - | - | - |
| Plasma lactate, mmol/L NR: 0.5–1 | 1.2 | 1.1 | 0.9 | 2.5 | 0.9 | 0.5 | 1.6 | 1.3 | 1.4 | 5.4 | 2.2 | 1.9 | 3.3 | 4.7 | 1.9 |
| D-dimer, ng/ml | - | - | - | 6,080 | - | - | - | - | - | 1,490 | 8,960 | - | - | >20,000 | >20,000 |
| Alanine aminotransferase, U/L NR: 16–35 | 27 | 27 | 53 | 18 | 20 | 20 | 61 | 96 | 74 | 38 | 34 | 24 | 60 | 70 | 54 |
| Brain-type natriuretic peptide, ng/ml | >35,000 | 18,492 | 15,964 | >35,000 | - | - | 5,134 | - | 5,633 | 16,717 | 24,056 | - | - | 30,061 | - |
| Troponin T, ng/L | 320 | 318 | 317 | 714 | - | 711 | 622 | - | - | - | 840 | 859 | - | 243 | 180 |
| . | MIS-A 11 . | MIS-A 12 . | MIS-A 13 . | MIS-A 14 . | MIS-A 15 . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day of hospitalization | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| Hemoglobin level, g/dL NR: 13–17.5 | 9.9 | 7.8 | 8.2 | 9.3 | 9.5 | 8.8 | 10.8 | 10.6 | 9.5 | 10 | 8.7 | 7.3 | 13.5 | 7.6 | 7.1 |
| Leukocyte count, × 109 cells/L NR: 4.0–10.0 | 18.9 | 9.2 | 7.4 | 31.9 | 24.0 | 23.3 | 19.5 | 29.3 | 25.2 | 25.3 | 24.1 | 41.4 | 9.5 | 15.0 | 27.2 |
| Lymphocytes count, 109 cells/L NR: 1.5–4.00 | 1.0 | 1.2 | 0.9 | 9.0 | - | - | 5.7 | 5.0 | - | 2.8 | - | 3.7 | 1.9 | - | - |
| Neutrophils count, 109 cells/L NR: 2.00–7.50 | 17.3 | 7.4 | 5.9 | 28.7 | - | - | 17.6 | 26.6 | - | 22.3 | - | 36.0 | 10.5 | - | - |
| Platelet count, × 109 cells/L NR: 150-400 | 193 | 221 | 279 | 195 | 233 | 268 | 244 | 303 | 345 | 198 | 152 | 192 | 125 | 145 | 182 |
| Plasma creatinine, µmol/L NR: 59–104 | 55 | 52 | 50 | 549 | 473 | 436 | 63 | 65 | 54 | 234 | 115 | 70 | 103 | 86 | 81 |
| C-reactive protein, mg/L NV <5 | 142 | - | 41 | 450 | - | - | 263 | 316 | - | 411 | - | - | 311 | - | - |
| Ferritin level, µg/L NR: 6–34 | - | - | - | - | - | - | - | - | - | - | - | 2,166 | - | - | - |
| Plasma lactate, mmol/L NR: 0.5–1 | 1.2 | 1.1 | 0.9 | 2.5 | 0.9 | 0.5 | 1.6 | 1.3 | 1.4 | 5.4 | 2.2 | 1.9 | 3.3 | 4.7 | 1.9 |
| D-dimer, ng/ml | - | - | - | 6,080 | - | - | - | - | - | 1,490 | 8,960 | - | - | >20,000 | >20,000 |
| Alanine aminotransferase, U/L NR: 16–35 | 27 | 27 | 53 | 18 | 20 | 20 | 61 | 96 | 74 | 38 | 34 | 24 | 60 | 70 | 54 |
| Brain-type natriuretic peptide, ng/ml | >35,000 | 18,492 | 15,964 | >35,000 | - | - | 5,134 | - | 5,633 | 16,717 | 24,056 | - | - | 30,061 | - |
| Troponin T, ng/L | 320 | 318 | 317 | 714 | - | 711 | 622 | - | - | - | 840 | 859 | - | 243 | 180 |
| . | MIS-A 16 . | ||
|---|---|---|---|
| Day of hospitalization | 1 | 2 | 3 |
| Hemoglobin level, g/dL NR: 13–17.5 | 12.0 | 12.1 | 11.0 |
| Lymphocytes count, 109 cells/L NR: 1.5–4.00 | 1.2 | - | 0.8 |
| Neutrophils count, 109 cells/L NR: 2.00–7.50 | 14.6 | - | 20.4 |
| Leukocyte count, × 109 cells/L NR: 4.0–10.0 | 16.8 | 15.1 | 21.6 |
| Platelet count, × 109 cells/L NR: 150–400 | 405 | 391 | 382 |
| Plasma creatinine, µmol/L NR: 59–104 | 77 | 64 | 59 |
| C-reactive protein, mg/L NV <5 | - | 253.7 | - |
| Ferritin level, µg/L NR: 6–34 | - | 919 | - |
| Plasma lactate, mmol/L NR: 0.5–1 | 1.4 | 1.3 | 1.5 |
| D-dimer, ng/ml | 3,270 | - | - |
| Alanine aminotransferase, U/L NR: 16–35 | 40 | 52 | 231 |
| Brain-type natriuretic peptide, ng/ml | 10,488 | - | - |
| Troponin T, ng/L | 1,540 | 590 | 164 |
| . | MIS-A 16 . | ||
|---|---|---|---|
| Day of hospitalization | 1 | 2 | 3 |
| Hemoglobin level, g/dL NR: 13–17.5 | 12.0 | 12.1 | 11.0 |
| Lymphocytes count, 109 cells/L NR: 1.5–4.00 | 1.2 | - | 0.8 |
| Neutrophils count, 109 cells/L NR: 2.00–7.50 | 14.6 | - | 20.4 |
| Leukocyte count, × 109 cells/L NR: 4.0–10.0 | 16.8 | 15.1 | 21.6 |
| Platelet count, × 109 cells/L NR: 150–400 | 405 | 391 | 382 |
| Plasma creatinine, µmol/L NR: 59–104 | 77 | 64 | 59 |
| C-reactive protein, mg/L NV <5 | - | 253.7 | - |
| Ferritin level, µg/L NR: 6–34 | - | 919 | - |
| Plasma lactate, mmol/L NR: 0.5–1 | 1.4 | 1.3 | 1.5 |
| D-dimer, ng/ml | 3,270 | - | - |
| Alanine aminotransferase, U/L NR: 16–35 | 40 | 52 | 231 |
| Brain-type natriuretic peptide, ng/ml | 10,488 | - | - |
| Troponin T, ng/L | 1,540 | 590 | 164 |
NR, normal range; NV, normal value.