Calculated risk ratio and Manders’ coefficients for each association of TLR9 with VAMPs 5, 7, and 8
| Resting | Spread (glass) | |||||
| Colocalization with TLR9 | Rr | M1 TLR9/VAMP | M2 VAMP/TLR9 | Rr | M1 TLR9/VAMP | M2 VAMP/TLR9 |
| VAMP 5 | 0.7 ± 0.1 | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.5 ± 0.1 | 0.5 ± 0.2 | 0.14 ± 0.04 |
| VAMP 7 | 0.84 ± 0.02 | 0.82 ± 0.08 | 0.4 ± 0.1 | 0.69 ± 0.09 | 0.56 ± 0.08 | 0.32 ± 0.09 |
| VAMP 8 | 0.50 ± 0.03 | 0.77 ± 0.02 | 0.59 ± 0.02 | 0.4 ± 0.1 | 0.68 ± 0.04 | 0.4 ± 0.2 |
| Resting | Spread (glass) | |||||
| Colocalization with TLR9 | Rr | M1 TLR9/VAMP | M2 VAMP/TLR9 | Rr | M1 TLR9/VAMP | M2 VAMP/TLR9 |
| VAMP 5 | 0.7 ± 0.1 | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.5 ± 0.1 | 0.5 ± 0.2 | 0.14 ± 0.04 |
| VAMP 7 | 0.84 ± 0.02 | 0.82 ± 0.08 | 0.4 ± 0.1 | 0.69 ± 0.09 | 0.56 ± 0.08 | 0.32 ± 0.09 |
| VAMP 8 | 0.50 ± 0.03 | 0.77 ± 0.02 | 0.59 ± 0.02 | 0.4 ± 0.1 | 0.68 ± 0.04 | 0.4 ± 0.2 |
Calculated risk ratio (Rr) and Manders’ coefficients for each association of TLR9 with VAMPs 5, 7, and 8 in human whole-blood PLTs under resting conditions and when activated (spread) on glass surface. Manders’ coefficients of 0.5 or greater were considered significant and are highlighted in bold.