Microarray analysis of Mesp1-GFP–expressing cells
| Category | Up-regulated genes |
| Transcription factors and chromatin remodeling | Hoxb1 (3.7), Foxc1* (3.5), Lmo1 (3.2), Foxc2* (3.0), Foxf1a (2.9), Pdlim4 (2.9), Isl1 (2.8), Hoxb2 (2.6), Mesp1 (2.6), Etv2 (2.4), Prrx2 (2.4), Tbx3 (2.4), Tbx6 (2.4), Snai1 (2.4), Lef1 (2.3), Msx2 (2.3), Smarcd3 (2.3), Mesp2 (2.2), Tbx2 (2.2), Evx1 (2.1), Hand1 (2.1), Meis2 (2.1), Prdm6 (2.1), Zcchc12 (2.1), Gata4 (2), Hand2 (2), Klhl6 (2), Msx1 (2), Six2 (2), Twist1* (2), Vax1 (2), Zeb2* (2), Bhlhe22 (1.9), Tbx20 (1.9), Zbtb7c (1.9), Ets1 (1.9), Hey2* (1.9), Smad6* (1.9), Zdhhc20* (1.9), Zcchc24* (1.9), Hmga2 (1.8), Hoxd1 (1.8), Pdlim5 (1.8), Tshz1 (1.8), Zfp516 (1.8), Hey1* (1.7), Smad1 (1.7), Cbx4 (1.7), Zfp423 (1.7), Foxh1 (1.6), Nfatc1* (1.6), Twist2* (1.6), Zeb1* (1.6) |
| Signaling pathways (other than receptors) | |
| Notch | Dll1 (2.1), Dll3 (2.0), Hey2 (1.9), Hey1 (1.7) |
| Wnt | Wnt5a (3), Wnt2 (2.8), Wnt5b (2.1), Apcdd1 (1.8), Lef1 (1.8), Wnt3 (1.7) |
| FGF | Fgf3 (2.3), Fgf15 (1.7), Fgf10 (1.6) |
| TGF-b | Gdf10 (2.7), Tgfb2 (2.0), Lefty2 (1.9), Tgfbi (1.9), Tgfb1i1 (1.8), Vasn (1.7) |
| Bmp | Bmper (2.4), Bmp4 (2.0), Bambi (1.7), Bmp6 (1.6), Smad6 (1.9), Smad1 (1.6) |
| Others | Rasgrp3 (2.4), Rgs5 (2.7), Crabp1 (2.7), Htr1d (2.6), Adcyap1r1 (2.5), S1pr5 (2.4), Ptgds (2.3), Dusp9 (2.3), Cap2 (2.0), Dlc1 (1.9), Tnfsf13b (1.9), Adcy3 (1.9), Dok4 (1.9), Efna3 (1.8), Braf (1.7), Prkd1 (1.7), Alox15 (1.6), Pgr (1.6), Vegfc (1.6) |
| Membrane proteins and receptors | Pcdh19 (3.1), Pdgfra (3.1), Ceacam10 (2.9), Cmklr1 (2.5), Gp1bb (2.5), Plac1 (2.5), Cacna1c (2.4), Odz4 (2.3), Nrp2 (2.3), Vldlr (2.3), Cdh4 (2.3), Pcdh18 (2.3), Adrb1 (2.2), Kdr (2.1), Rftn1 (2.1), Unc5c (2.1), Lhfp (2.0), Kcnd3 (2.0), Il13ra1 (2.0), Amhr2 (2.0), Cd160 (1.9), L1cam (1.9), Cxcr4 (1.9), Aplnr (1.9), Pcdh7 (1.9), Cxcr7 (1.9), Slc4a4 (1.9), Gpr177 (1.8), Itga8 (1.8), Prtg (1.8), Ednra (1.8), Kcnc1 (1.8), Cdh11 (1.7), Pcdh7 (1.7), Pdgfrb (1.7), Gfra2 (1.7), Trpc3 (1.7), Nrp1 (1.7), Cdh2 (1.7), Tmem88 (1.6), Il1rap (1.6), Lrp1 (1.6), Ms4a4d (1.6), Kctd15 (1.5) |
| Extracellular matrix | Col6a1 (3.5), Col9a1 (2.6), Emid2 (2.4), Leprel1 (2.3), Fbln2 (2.2), Fbln7 (2.1), Lor (2.0), Col13a1 (2.0), Fn1 (1.9), Has2 (1.8), Vcan (1.6), Flnb (1.6), Mmp2 (1.6) |
| Others | Spp1 (5.8), Fabp4 (5.5), H60a (4.5), Ugt1a1 (4.0), Papss2 (3.8), Agpat9 (3.1), Ccdc109b (2.8), Phlda2 (2.6), Egln3 (2.5), Gna14 (2.5), Pcsk5 (2.4), Atp1a2 (2.4), Dock10 (2.3), Hs3st3b1 (2.3), Morc4 (2.3), Chst2 (2.3), Pmp22 (2.3), Adamts20 (2.2), St6galnac4 (2.2), Exoc3l (2.2), Fam123c (2.1), Myl7 (2.1), Prdm6 (2.1), Susd5 (2.1), Rbm24 (2.1), Siah2 (2.1), Mex3b (2.1), Chst7 (2.0), Nin (2.0), Actc1 (2.0), Kif26b (2.0), Ccnd2 (2.0), Itih5 (1.9), Man1c1 (1.9), Cbln1 (1.9), Mn1 (1.9), Sh3bp1 (1.9), Fam82a1 (1.8), Olfm1 (1.8), Serpinb9 (1.8), Cdkn1c (1.8), Phldb2 (1.8), Pmaip1 (1.8), Gas1 (1.8), Abtb2 (1.8), Adamts3 (1.7), Sgcb (1.7), Sbsn (1.7), Cyp2s1 (1.7), Adam19 (1.7), Brp44 (1.7), Cyp4f15 (1.7), Dclk1 (1.7), Slco3a1 (1.7), Bace2 (1.7), Car3 (1.7), Aard (1.6), Oaf (1.6), Zadh2 (1.6), As3mt (1.6), Grrp1 (1.6), Ablim1 (1.6), Fam122b (1.6), Gne (1.6), Ptprm (1.6), Rps6ka6 (1.6), Lmna (1.5), Man1a (1.5), Pwwp2b (1.5) |
| Category | Up-regulated genes |
| Transcription factors and chromatin remodeling | Hoxb1 (3.7), Foxc1* (3.5), Lmo1 (3.2), Foxc2* (3.0), Foxf1a (2.9), Pdlim4 (2.9), Isl1 (2.8), Hoxb2 (2.6), Mesp1 (2.6), Etv2 (2.4), Prrx2 (2.4), Tbx3 (2.4), Tbx6 (2.4), Snai1 (2.4), Lef1 (2.3), Msx2 (2.3), Smarcd3 (2.3), Mesp2 (2.2), Tbx2 (2.2), Evx1 (2.1), Hand1 (2.1), Meis2 (2.1), Prdm6 (2.1), Zcchc12 (2.1), Gata4 (2), Hand2 (2), Klhl6 (2), Msx1 (2), Six2 (2), Twist1* (2), Vax1 (2), Zeb2* (2), Bhlhe22 (1.9), Tbx20 (1.9), Zbtb7c (1.9), Ets1 (1.9), Hey2* (1.9), Smad6* (1.9), Zdhhc20* (1.9), Zcchc24* (1.9), Hmga2 (1.8), Hoxd1 (1.8), Pdlim5 (1.8), Tshz1 (1.8), Zfp516 (1.8), Hey1* (1.7), Smad1 (1.7), Cbx4 (1.7), Zfp423 (1.7), Foxh1 (1.6), Nfatc1* (1.6), Twist2* (1.6), Zeb1* (1.6) |
| Signaling pathways (other than receptors) | |
| Notch | Dll1 (2.1), Dll3 (2.0), Hey2 (1.9), Hey1 (1.7) |
| Wnt | Wnt5a (3), Wnt2 (2.8), Wnt5b (2.1), Apcdd1 (1.8), Lef1 (1.8), Wnt3 (1.7) |
| FGF | Fgf3 (2.3), Fgf15 (1.7), Fgf10 (1.6) |
| TGF-b | Gdf10 (2.7), Tgfb2 (2.0), Lefty2 (1.9), Tgfbi (1.9), Tgfb1i1 (1.8), Vasn (1.7) |
| Bmp | Bmper (2.4), Bmp4 (2.0), Bambi (1.7), Bmp6 (1.6), Smad6 (1.9), Smad1 (1.6) |
| Others | Rasgrp3 (2.4), Rgs5 (2.7), Crabp1 (2.7), Htr1d (2.6), Adcyap1r1 (2.5), S1pr5 (2.4), Ptgds (2.3), Dusp9 (2.3), Cap2 (2.0), Dlc1 (1.9), Tnfsf13b (1.9), Adcy3 (1.9), Dok4 (1.9), Efna3 (1.8), Braf (1.7), Prkd1 (1.7), Alox15 (1.6), Pgr (1.6), Vegfc (1.6) |
| Membrane proteins and receptors | Pcdh19 (3.1), Pdgfra (3.1), Ceacam10 (2.9), Cmklr1 (2.5), Gp1bb (2.5), Plac1 (2.5), Cacna1c (2.4), Odz4 (2.3), Nrp2 (2.3), Vldlr (2.3), Cdh4 (2.3), Pcdh18 (2.3), Adrb1 (2.2), Kdr (2.1), Rftn1 (2.1), Unc5c (2.1), Lhfp (2.0), Kcnd3 (2.0), Il13ra1 (2.0), Amhr2 (2.0), Cd160 (1.9), L1cam (1.9), Cxcr4 (1.9), Aplnr (1.9), Pcdh7 (1.9), Cxcr7 (1.9), Slc4a4 (1.9), Gpr177 (1.8), Itga8 (1.8), Prtg (1.8), Ednra (1.8), Kcnc1 (1.8), Cdh11 (1.7), Pcdh7 (1.7), Pdgfrb (1.7), Gfra2 (1.7), Trpc3 (1.7), Nrp1 (1.7), Cdh2 (1.7), Tmem88 (1.6), Il1rap (1.6), Lrp1 (1.6), Ms4a4d (1.6), Kctd15 (1.5) |
| Extracellular matrix | Col6a1 (3.5), Col9a1 (2.6), Emid2 (2.4), Leprel1 (2.3), Fbln2 (2.2), Fbln7 (2.1), Lor (2.0), Col13a1 (2.0), Fn1 (1.9), Has2 (1.8), Vcan (1.6), Flnb (1.6), Mmp2 (1.6) |
| Others | Spp1 (5.8), Fabp4 (5.5), H60a (4.5), Ugt1a1 (4.0), Papss2 (3.8), Agpat9 (3.1), Ccdc109b (2.8), Phlda2 (2.6), Egln3 (2.5), Gna14 (2.5), Pcsk5 (2.4), Atp1a2 (2.4), Dock10 (2.3), Hs3st3b1 (2.3), Morc4 (2.3), Chst2 (2.3), Pmp22 (2.3), Adamts20 (2.2), St6galnac4 (2.2), Exoc3l (2.2), Fam123c (2.1), Myl7 (2.1), Prdm6 (2.1), Susd5 (2.1), Rbm24 (2.1), Siah2 (2.1), Mex3b (2.1), Chst7 (2.0), Nin (2.0), Actc1 (2.0), Kif26b (2.0), Ccnd2 (2.0), Itih5 (1.9), Man1c1 (1.9), Cbln1 (1.9), Mn1 (1.9), Sh3bp1 (1.9), Fam82a1 (1.8), Olfm1 (1.8), Serpinb9 (1.8), Cdkn1c (1.8), Phldb2 (1.8), Pmaip1 (1.8), Gas1 (1.8), Abtb2 (1.8), Adamts3 (1.7), Sgcb (1.7), Sbsn (1.7), Cyp2s1 (1.7), Adam19 (1.7), Brp44 (1.7), Cyp4f15 (1.7), Dclk1 (1.7), Slco3a1 (1.7), Bace2 (1.7), Car3 (1.7), Aard (1.6), Oaf (1.6), Zadh2 (1.6), As3mt (1.6), Grrp1 (1.6), Ablim1 (1.6), Fam122b (1.6), Gne (1.6), Ptprm (1.6), Rps6ka6 (1.6), Lmna (1.5), Man1a (1.5), Pwwp2b (1.5) |
Fold changes are indicated in parentheses. Asterisks indicate genes found only in one of the two array replicates and confirmed by RT-PCR on different biological samples. Bold indicates genes found to be also up-regulated after Mesp1 overexpression.