Table I.

Genes identified in the S2 cell screen and confirmed with nonoverlapping dsRNA

Cg Gene symbol Homologue/domain Z score Class 
8416 Rho1 RhoC 5.8 
2023 Cg2023 Sec20 3.6 
7057 AP-50 AP-2µ1 3.2 
7262 Cg7262 Nucleoporin 93 3.0 
9156 PP1-13C PP1cc 3.0 
3320 Rab1 Rab1A 3.8 II 
8385 Arf79F Arf1 3.3 II 
32687 Cg32687 Leucine-rich repeat 58 3.0 II 
11427 Ruby AP-3β2 3.8 III 
11197 Garnet AP-3∂1 3.7 III 
8945 Cg8945 Carboxypeptidase 3.4 III 
14899 Cg14899 Derlin-2 3.3 III 
3201 Mlc-c Myosin light chain 3.3 III 
4707 Cg4707 Zinc finger 3.1 III 
1973 Yata Scy1-like kinase 3.0 III 
8027 Cg8027 GlcNAc-1-phosphotransferase (α3.0 III 
Cg Gene symbol Homologue/domain Z score Class 
8416 Rho1 RhoC 5.8 
2023 Cg2023 Sec20 3.6 
7057 AP-50 AP-2µ1 3.2 
7262 Cg7262 Nucleoporin 93 3.0 
9156 PP1-13C PP1cc 3.0 
3320 Rab1 Rab1A 3.8 II 
8385 Arf79F Arf1 3.3 II 
32687 Cg32687 Leucine-rich repeat 58 3.0 II 
11427 Ruby AP-3β2 3.8 III 
11197 Garnet AP-3∂1 3.7 III 
8945 Cg8945 Carboxypeptidase 3.4 III 
14899 Cg14899 Derlin-2 3.3 III 
3201 Mlc-c Myosin light chain 3.3 III 
4707 Cg4707 Zinc finger 3.1 III 
1973 Yata Scy1-like kinase 3.0 III 
8027 Cg8027 GlcNAc-1-phosphotransferase (α3.0 III 

List of genes identified as positive in the S2 cell screen using GFP-/HA-tagged dVMAT as reporter. The z score indicates significance assessed using a within-plate comparison. Class I dsRNAs increase cell surface expression of DE/AA dVMAT, class II reduce surface expression of the mutant, and class III have no effect.

or Create an Account

Close Modal
Close Modal