Table 1.

SpinX pole refinement algorithm to compensate overestimation of spindle length axis

StepsInputOutput
Perform MVEE as usual based on spindle signal to predict pole position First estimation of (x,y,z) for Poles 1 and 2 
Create max projection of the spindle mask to identify spindle boundary Max projection of mask 
Extract 3D coordinates along the spindle length axis (pole-to-pole axis) and obtain the corresponding pixel values (conversion from float to integer results in rounding bias) 1-D array with pixel values obtained from the max projected mask 
Identify the first and last occurrence of the array which corresponds to the poles Refined (x,y,z) for Poles 1 and 2 
Re-calculate the centroid and radius of the refined poles and use them as input to re-apply ellipsoid fitting to update data frame and generated plots (increase computational run time marginally) Updated data frame 
StepsInputOutput
Perform MVEE as usual based on spindle signal to predict pole position First estimation of (x,y,z) for Poles 1 and 2 
Create max projection of the spindle mask to identify spindle boundary Max projection of mask 
Extract 3D coordinates along the spindle length axis (pole-to-pole axis) and obtain the corresponding pixel values (conversion from float to integer results in rounding bias) 1-D array with pixel values obtained from the max projected mask 
Identify the first and last occurrence of the array which corresponds to the poles Refined (x,y,z) for Poles 1 and 2 
Re-calculate the centroid and radius of the refined poles and use them as input to re-apply ellipsoid fitting to update data frame and generated plots (increase computational run time marginally) Updated data frame 

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