Table 1.
Plasmids used in this study
VectorDescriptionSource
pDONR221 Gateway donor vector Thermo Fisher Scientific 
pENTR1A Gateway entry vector Thermo Fisher Scientific 
pDestMyc Mammalian N-terminal Myc-tag fusion expression vector with CMV and T7 promoters (Lamark et al., 2003) 
pDest-3xFLAG Mammalian N-terminal 3xFlag-tag fusion expression vector with CMV promoter (Jain et al., 2010) 
pDest15 Bacterial GST fusion expression vector with a T7 promoter Thermo Fisher Scientific 
pENTR223-SAMM50 Human SAMM50 in Gateway entry vector This study 
pDestMyc-SAMM50 Human SAMM50 with N-terminal Myc tag This study 
pDest15 SAMM50 Human SAMM50 with N-terminal GST fusion tag This study 
pDest15 p62 Human p62 with N-terminal GST fusion tag (Jain et al., 2010) 
pDest 3xFLAG Mammalian triple FLAG tag fusion expression vector with CMV promoter (Jain et al., 2010) 
pDest 3xFLAG p62 Human p62 with N-terminal 3xFLAG tag (Jain et al., 2010) 
pDest 3xFLAG LC3B Human LC3B with N-terminal 3xFLAG tag This study 
pDest 3xFLAG GABARAP Human GABARAP with N-terminal 3xFLAG tag This study 
pDest15 p62 ΔPB1 Human p62 with PB1 domain deletion and N-terminal GST fusion tag This study 
pDest15 p62 Δ123–170 Human p62 with 123–170 deletion and N-terminal GST fusion tag This study 
pDest15 p62 Δ170–256 Human p62 with 170–256 deletion and N-terminal GST fusion tag This study 
pDest15 p62 Δ256–370 Human p62 with 256–370 deletion and N-terminal GST fusion tag This study 
pDest15 p62 Δ371–385 Human p62 with 371–385 deletion and N-terminal GST fusion tag This study 
pDest15 p62 ΔUBA Human p62 with UBA domain deletion and N-terminal GST fusion tag This study 
pDONR221 MIC60 Human MIC60 in Gateway donor vector Harvard 
pDest15 MIC60 Human MIC60 with N-terminal GST fusion tag This study 
pENTR223 MIC19 Human MIC19 in Gateway entry vector Harvard 
pDest15 MIC19 Human MIC19 with N-terminal GST fusion tag This study 
pENTR VDAC1 Human VDAC1 in Gateway entry vector This study 
pDest15 VDAC1 Human VDAC1 with N-terminal GST fusion tag This study 
pENTR MTX1 Human MTX1 in Gateway entry vector This study 
pDest15 MTX1 Human MTX1 with N-terminal GST fusion tag This study 
pDestMyc-MTX1 Human MTX1 with N-terminal Myc tag This study 
pENTR MTX2 Human MTX2 in Gateway entry vector This study 
pDestMyc-MTX2 Human MTX2 with N-terminal Myc tag This study 
pDest15 MTX2 Human MIC60 with N-terminal GST fusion tag This study 
pDONR221 SAMM50 Δ1–40 Human SAMM50 with 1–40 deletion in Gateway donor vector This study 
pDONR221 SAMM50 Δ1–70 Human SAMM50 with 1–70 deletion in Gateway donor vector This study 
pDONR221 SAMM50 Δ1–100 Human SAMM50 with 1–100 deletion in Gateway donor vector This study 
pDONR221 SAMM50 Δ1–125 Human SAMM50 with 1–125 deletion in Gateway donor vector This study 
pDestMyc SAMM50 Δ1–40 Human SAMM50 with 1–40 deletion and N-terminal Myc tag This study 
pDestMyc SAMM50 Δ1–70 Human SAMM50 with 1–70 deletion and N-terminal Myc tag This study 
pDestMyc SAMM50 Δ1–100 Human SAMM50 with 1–100 deletion and N-terminal Myc tag This study 
pDestMyc SAMM50 Δ1–125 Human SAMM50 with 1–125 deletion and N-terminal Myc tag This study 
pMXS-puro Retroviral vector with Moloney murine leukemia virus promoter CellBiolabs RTV-012 
pMRXIP Retroviral vector and MMLV promoter (backbone is pMRXIP-GFP-STX17; Addgene, 45909) This study 
pMXs puro-mCherry PARKIN Retroviral vector with Human PARKIN and N-terminal mCherry fusion tag This study 
pMXs puro-Myc-SAMM50 Retroviral vector with Human SAMM50 and N-terminal Myc tag This study 
pMXs puro-Myc SAMM50 Δ1–40 Retroviral vector with Human SAMM50 Δ1–40 and N-terminal Myc tag This study 
pMXs puro-Myc SAMM50 Δ1–70 Retroviral vector with Human SAMM50 Δ1–70 and N-terminal Myc tag This study 
pMXs puro-Myc SAMM50 Δ1–100 Retroviral vector with Human SAMM50 Δ1–100 and N-terminal Myc tag This study 
pMXs puro-Myc SAMM50 Δ1–125 Retroviral vector with Human SAMM50 Δ1–125 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Retroviral vector with Human SAMM50 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–40 Retroviral vector with Human SAMM50 Δ1–40 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–70 Retroviral vector with Human SAMM50 Δ1–70 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–100 Retroviral vector with Human SAMM50 Δ1–100 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–125 Retroviral vector with Human SAMM50 Δ1–125 and N-terminal Myc tag This study 
pMRXIP GFP-SAMM50 Retroviral vector with Human SAMM50 and N-terminal GFP fusion tag This study 
pMRXIP GFP-SAMM50 Δ1–125 Retroviral vector with Human SAMM50 Δ1–125 and N-terminal GFP fusion tag This study 
pDest15 LC3A Human LC3A with N-terminal GST fusion tag (Pankiv et al., 2007) 
pDest15 LC3B Human LC3B with N-terminal GST fusion tag Pankiv et al., 2007  
pDest15 LC3C Human LC3C with N-terminal GST fusion tag (Pankiv et al., 2007) 
pDest15 GABARAP Human GABARAP with N-terminal GST fusion tag (Pankiv et al., 2007) 
pDest15 GABARAPL1 Human GABARAPL1 with N-terminal GST fusion tag (Pankiv et al., 2007) 
pDest15 GABARAPL2 HumanGABARAPL2 with N-terminal GST fusion tag (Pankiv et al., 2007) 
pDest15 GABARAP Y49A Human GABARAP Y49A with N-terminal GST fusion tag This study 
pDONR221 SAMM50 F28A/V31A Human SAMM50 with F28A/V31A point mutations in Gateway donor vector This study 
pDONR221 SAMM50 Δ28–31 Human SAMM50 with 28–31 deletion in Gateway donor vector This study 
pDONR221 SAMM50 Δ24–35 Human SAMM50 with 24–35 deletion in Gateway donor vector This study 
pDestMyc SAMM50 F28A/V31A Human SAMM50 with F28A/V31A point mutations and N-terminal Myc tag This study 
pDestMyc SAMM50 Δ28–31 Human SAMM50 with 28–31 deletion and N-terminal Myc tag This study 
pDestMyc SAMM50 Δ24–35 Human SAMM50 with 24–35 deletion and N-terminal Myc tag This study 
pMXs-puro mCherry-EGFP OMP25TM Retroviral vector with tandem tag mCherry-EGFP OMP25TM mitophagy reporter This study 
pMRXIP Myc-LC3A Retroviral vector with Human LC3A and N-terminal Myc tag This study 
pMRXIP Myc-LC3B Retroviral vector with Human LC3B and N-terminal Myc tag This study 
pMRXIP Myc-LC3C Retroviral vector with Human LC3C and N-terminal Myc tag This study 
pMRXIP Myc-GABARAP Retroviral vector with Human GABARAP and N-terminal Myc tag This study 
pMRXIP Myc-GABARAPL1 Retroviral vector with Human GABARAPL1 and N-terminal Myc tag This study 
pMRXIP Myc-GABARAPL2 Retroviral vector with Human GABARAPL2and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Retroviral vector with Human SAMM50 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–40 Retroviral vector with Human SAMM50 Δ1–40 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–70 Retroviral vector with Human SAMM50 Δ1–70 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–100 Retroviral vector with Human SAMM50 Δ1–100 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–125 Retroviral vector with Human SAMM50 Δ1–125 and N-terminal Myc tag This study 
pMRXIP COX8-EGFP-mCherry Retroviral vector with tandem tag COX8-EGFP-mCherry mitophagy reporter This study 
pCDNA5/FRT-mNG1-10 Flip-In vector with modified mNeonGreen β-sheet 1–10 (mNG1-10This study 
pMRXIP-mNG11-SAMM50 Retroviral vector with the Human SAMM50 and N-terminal mNG11 tag This study 
pMRXIP-mNG11-SAMM50 Retroviral vector with the Human p62 and N-terminal mNG11 tag This study 
pCDNA5/FRT-MIC19-EGFP Flip-In vector with Human MIC19 and C-terminal EGFP tag This study 
pMRXIP-MIC19-mCherry Retroviral vector with Human MIC19 and C-terminal mCherry tag This study 
pCDNA5/FRT-LAMP1-mCherry Flip-In vector with Human LAMP1 and C-terminal mCherry tag This study 
pMRXIP-LAMP1-EGFP Retroviral vector with Human LAMP1 and C-terminal EGFP tag This study 
pMRXIP-EGFP-p62 Retroviral vector with Human p62 and N-terminal EGFP tag This study 
pMRXIP-EGFP-LC3A Retroviral vector with Human LC3A and N-terminal EGFP tag This study 
pMRXIP-EGFP-GABARAP Retroviral vector with Human GABARAP and N-terminal EGFP tag This study 
pCDH-EF1α-GW-IRES-puromycin Lentiviral vector with eukaryotic elongation factor 1 alpha (EF1α) promoter System Biosciences 
pCDH-EF1α-GW-IRES-puromycin-mCherry-p62 Lentiviral vector with p62 and N-terminal mCherry tag This study 
pCDH-EF1α-GW-IRES-puromycin-Myc-p62 Lentiviral vector with p62 and N-terminal Myc tag This study 
pCDH-EF1α-GW-IRES-puromycin-Myc-p62 Δ170–256 Lentiviral vector with p62 Δ170-256 and N-terminal mCherry tag This study 
pCDH-EF1α-GW-IRES-puromycin-mCherry-ATG13 Lentiviral vector with ATG13 and N-terminal mCherry tag This study 
pCDH-EF1α-GW-IRES-puromycin-mCherry-GABARAP Lentiviral vector with GABARAP and N-terminal mCherry tag This study 
   
VectorDescriptionSource
pDONR221 Gateway donor vector Thermo Fisher Scientific 
pENTR1A Gateway entry vector Thermo Fisher Scientific 
pDestMyc Mammalian N-terminal Myc-tag fusion expression vector with CMV and T7 promoters (Lamark et al., 2003) 
pDest-3xFLAG Mammalian N-terminal 3xFlag-tag fusion expression vector with CMV promoter (Jain et al., 2010) 
pDest15 Bacterial GST fusion expression vector with a T7 promoter Thermo Fisher Scientific 
pENTR223-SAMM50 Human SAMM50 in Gateway entry vector This study 
pDestMyc-SAMM50 Human SAMM50 with N-terminal Myc tag This study 
pDest15 SAMM50 Human SAMM50 with N-terminal GST fusion tag This study 
pDest15 p62 Human p62 with N-terminal GST fusion tag (Jain et al., 2010) 
pDest 3xFLAG Mammalian triple FLAG tag fusion expression vector with CMV promoter (Jain et al., 2010) 
pDest 3xFLAG p62 Human p62 with N-terminal 3xFLAG tag (Jain et al., 2010) 
pDest 3xFLAG LC3B Human LC3B with N-terminal 3xFLAG tag This study 
pDest 3xFLAG GABARAP Human GABARAP with N-terminal 3xFLAG tag This study 
pDest15 p62 ΔPB1 Human p62 with PB1 domain deletion and N-terminal GST fusion tag This study 
pDest15 p62 Δ123–170 Human p62 with 123–170 deletion and N-terminal GST fusion tag This study 
pDest15 p62 Δ170–256 Human p62 with 170–256 deletion and N-terminal GST fusion tag This study 
pDest15 p62 Δ256–370 Human p62 with 256–370 deletion and N-terminal GST fusion tag This study 
pDest15 p62 Δ371–385 Human p62 with 371–385 deletion and N-terminal GST fusion tag This study 
pDest15 p62 ΔUBA Human p62 with UBA domain deletion and N-terminal GST fusion tag This study 
pDONR221 MIC60 Human MIC60 in Gateway donor vector Harvard 
pDest15 MIC60 Human MIC60 with N-terminal GST fusion tag This study 
pENTR223 MIC19 Human MIC19 in Gateway entry vector Harvard 
pDest15 MIC19 Human MIC19 with N-terminal GST fusion tag This study 
pENTR VDAC1 Human VDAC1 in Gateway entry vector This study 
pDest15 VDAC1 Human VDAC1 with N-terminal GST fusion tag This study 
pENTR MTX1 Human MTX1 in Gateway entry vector This study 
pDest15 MTX1 Human MTX1 with N-terminal GST fusion tag This study 
pDestMyc-MTX1 Human MTX1 with N-terminal Myc tag This study 
pENTR MTX2 Human MTX2 in Gateway entry vector This study 
pDestMyc-MTX2 Human MTX2 with N-terminal Myc tag This study 
pDest15 MTX2 Human MIC60 with N-terminal GST fusion tag This study 
pDONR221 SAMM50 Δ1–40 Human SAMM50 with 1–40 deletion in Gateway donor vector This study 
pDONR221 SAMM50 Δ1–70 Human SAMM50 with 1–70 deletion in Gateway donor vector This study 
pDONR221 SAMM50 Δ1–100 Human SAMM50 with 1–100 deletion in Gateway donor vector This study 
pDONR221 SAMM50 Δ1–125 Human SAMM50 with 1–125 deletion in Gateway donor vector This study 
pDestMyc SAMM50 Δ1–40 Human SAMM50 with 1–40 deletion and N-terminal Myc tag This study 
pDestMyc SAMM50 Δ1–70 Human SAMM50 with 1–70 deletion and N-terminal Myc tag This study 
pDestMyc SAMM50 Δ1–100 Human SAMM50 with 1–100 deletion and N-terminal Myc tag This study 
pDestMyc SAMM50 Δ1–125 Human SAMM50 with 1–125 deletion and N-terminal Myc tag This study 
pMXS-puro Retroviral vector with Moloney murine leukemia virus promoter CellBiolabs RTV-012 
pMRXIP Retroviral vector and MMLV promoter (backbone is pMRXIP-GFP-STX17; Addgene, 45909) This study 
pMXs puro-mCherry PARKIN Retroviral vector with Human PARKIN and N-terminal mCherry fusion tag This study 
pMXs puro-Myc-SAMM50 Retroviral vector with Human SAMM50 and N-terminal Myc tag This study 
pMXs puro-Myc SAMM50 Δ1–40 Retroviral vector with Human SAMM50 Δ1–40 and N-terminal Myc tag This study 
pMXs puro-Myc SAMM50 Δ1–70 Retroviral vector with Human SAMM50 Δ1–70 and N-terminal Myc tag This study 
pMXs puro-Myc SAMM50 Δ1–100 Retroviral vector with Human SAMM50 Δ1–100 and N-terminal Myc tag This study 
pMXs puro-Myc SAMM50 Δ1–125 Retroviral vector with Human SAMM50 Δ1–125 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Retroviral vector with Human SAMM50 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–40 Retroviral vector with Human SAMM50 Δ1–40 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–70 Retroviral vector with Human SAMM50 Δ1–70 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–100 Retroviral vector with Human SAMM50 Δ1–100 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–125 Retroviral vector with Human SAMM50 Δ1–125 and N-terminal Myc tag This study 
pMRXIP GFP-SAMM50 Retroviral vector with Human SAMM50 and N-terminal GFP fusion tag This study 
pMRXIP GFP-SAMM50 Δ1–125 Retroviral vector with Human SAMM50 Δ1–125 and N-terminal GFP fusion tag This study 
pDest15 LC3A Human LC3A with N-terminal GST fusion tag (Pankiv et al., 2007) 
pDest15 LC3B Human LC3B with N-terminal GST fusion tag Pankiv et al., 2007  
pDest15 LC3C Human LC3C with N-terminal GST fusion tag (Pankiv et al., 2007) 
pDest15 GABARAP Human GABARAP with N-terminal GST fusion tag (Pankiv et al., 2007) 
pDest15 GABARAPL1 Human GABARAPL1 with N-terminal GST fusion tag (Pankiv et al., 2007) 
pDest15 GABARAPL2 HumanGABARAPL2 with N-terminal GST fusion tag (Pankiv et al., 2007) 
pDest15 GABARAP Y49A Human GABARAP Y49A with N-terminal GST fusion tag This study 
pDONR221 SAMM50 F28A/V31A Human SAMM50 with F28A/V31A point mutations in Gateway donor vector This study 
pDONR221 SAMM50 Δ28–31 Human SAMM50 with 28–31 deletion in Gateway donor vector This study 
pDONR221 SAMM50 Δ24–35 Human SAMM50 with 24–35 deletion in Gateway donor vector This study 
pDestMyc SAMM50 F28A/V31A Human SAMM50 with F28A/V31A point mutations and N-terminal Myc tag This study 
pDestMyc SAMM50 Δ28–31 Human SAMM50 with 28–31 deletion and N-terminal Myc tag This study 
pDestMyc SAMM50 Δ24–35 Human SAMM50 with 24–35 deletion and N-terminal Myc tag This study 
pMXs-puro mCherry-EGFP OMP25TM Retroviral vector with tandem tag mCherry-EGFP OMP25TM mitophagy reporter This study 
pMRXIP Myc-LC3A Retroviral vector with Human LC3A and N-terminal Myc tag This study 
pMRXIP Myc-LC3B Retroviral vector with Human LC3B and N-terminal Myc tag This study 
pMRXIP Myc-LC3C Retroviral vector with Human LC3C and N-terminal Myc tag This study 
pMRXIP Myc-GABARAP Retroviral vector with Human GABARAP and N-terminal Myc tag This study 
pMRXIP Myc-GABARAPL1 Retroviral vector with Human GABARAPL1 and N-terminal Myc tag This study 
pMRXIP Myc-GABARAPL2 Retroviral vector with Human GABARAPL2and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Retroviral vector with Human SAMM50 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–40 Retroviral vector with Human SAMM50 Δ1–40 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–70 Retroviral vector with Human SAMM50 Δ1–70 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–100 Retroviral vector with Human SAMM50 Δ1–100 and N-terminal Myc tag This study 
pMRXIP Myc-SAMM50 Δ1–125 Retroviral vector with Human SAMM50 Δ1–125 and N-terminal Myc tag This study 
pMRXIP COX8-EGFP-mCherry Retroviral vector with tandem tag COX8-EGFP-mCherry mitophagy reporter This study 
pCDNA5/FRT-mNG1-10 Flip-In vector with modified mNeonGreen β-sheet 1–10 (mNG1-10This study 
pMRXIP-mNG11-SAMM50 Retroviral vector with the Human SAMM50 and N-terminal mNG11 tag This study 
pMRXIP-mNG11-SAMM50 Retroviral vector with the Human p62 and N-terminal mNG11 tag This study 
pCDNA5/FRT-MIC19-EGFP Flip-In vector with Human MIC19 and C-terminal EGFP tag This study 
pMRXIP-MIC19-mCherry Retroviral vector with Human MIC19 and C-terminal mCherry tag This study 
pCDNA5/FRT-LAMP1-mCherry Flip-In vector with Human LAMP1 and C-terminal mCherry tag This study 
pMRXIP-LAMP1-EGFP Retroviral vector with Human LAMP1 and C-terminal EGFP tag This study 
pMRXIP-EGFP-p62 Retroviral vector with Human p62 and N-terminal EGFP tag This study 
pMRXIP-EGFP-LC3A Retroviral vector with Human LC3A and N-terminal EGFP tag This study 
pMRXIP-EGFP-GABARAP Retroviral vector with Human GABARAP and N-terminal EGFP tag This study 
pCDH-EF1α-GW-IRES-puromycin Lentiviral vector with eukaryotic elongation factor 1 alpha (EF1α) promoter System Biosciences 
pCDH-EF1α-GW-IRES-puromycin-mCherry-p62 Lentiviral vector with p62 and N-terminal mCherry tag This study 
pCDH-EF1α-GW-IRES-puromycin-Myc-p62 Lentiviral vector with p62 and N-terminal Myc tag This study 
pCDH-EF1α-GW-IRES-puromycin-Myc-p62 Δ170–256 Lentiviral vector with p62 Δ170-256 and N-terminal mCherry tag This study 
pCDH-EF1α-GW-IRES-puromycin-mCherry-ATG13 Lentiviral vector with ATG13 and N-terminal mCherry tag This study 
pCDH-EF1α-GW-IRES-puromycin-mCherry-GABARAP Lentiviral vector with GABARAP and N-terminal mCherry tag This study 
   

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