Table 1.
List of the top 52 proteins sorted by SPK-CEN ratio
#Gene nameEntry IDSPK-CEN ratioProtein domainsGO annotated processLocalization (IF)IF references
1 SON P18583 4.918 LCD, DRBM, G patch Splicing NS HPA, Saitoh et al. (2004)  
2 SRRM2 Q9UQ35 4.642 LCD, coiled coil Splicing NS HPA, Mintz et al. (1999)  
3 PRPF40A O75400 3.050 LCD, coiled coil, WW Splicing NS HPA 
4 RBM25 P49756 2.722 LCD, RRM, coiled coil, PWI Splicing NS HPA, Zhou et al. (2008)  
5 ZNF207 O43670 2.564 LCD, ZnF Transcription NS Rai et al. (2018), this study 
6 LUC7L2 Q9Y383 2.413 LCD, coiled coil Splicing NS Howell et al. (2007)  
7 SRRM1 Q8IYB3 2.409 LCD, PWI Splicing NS HPA 
8 WTAP Q15007 2.373 LCD, coiled coil Splicing NS HPA, Little et al. (2000)  
9 ZC3H14 Q6PJT7 2.362 LCD, ZnF Poly(A) binding NS HPA, Leung et al. (2009)  
10 ACIN1 Q9UKV3 2.341 LCD, coiled coil, RRM, SAP Splicing NS Saitoh et al. (2004)  
11 SAP18 O00422 2.328 LCD Splicing NS Singh et al. (2010)  
12 DDX46 Q7L014 2.299 LCD, DEXD, HELICc Splicing NS HPA, Will et al. (2002)  
13 TRA2A Q13595 2.295 LCD, RRM Splicing NS Platt et al. (2015)  
14 SRSF2 Q01130 2.284 LCD, RRM Splicing NS Fu and Maniatis (1990)  
15 DDX23 Q9BUQ8 2.263 LCD, coiled coil, DEXDc, HELICc Splicing NP HPA 
16 CDK12 Q9NYV4 2.247 LCD, S_TKc Transcription NS Ko et al. (2001)  
17 PRPF4B Q13523 2.239 LCD, coiled coil Splicing NS HPA 
18 LUC7L3 O95232 2.238 LCD, coiled coil Splicing NS HPA, Umehara et al. (2003)  
19 MFAP1 P55081 2.230 LCD, coiled coil Splicing NS This study, Salas-Armenteros et al. (2019)  
20 SF3A1 Q07955 2.227 LCD, RRM Splicing NS HPA, Huang et al. (2011)  
21 SF3B2 Q13435 2.205 LCD, coiled coil Splicing NS HPA, Terada and Yasuda (2006)  
22 RBM39 Q14498 2.200 LCD, RRM Splicing NS HPA, Imai et al. (1993)  
23 RBM10 P98175 2.181 LCD, RRM, ZnF, G patch Splicing NS HPA, Inoue et al. (2008)  
24 SRSF1 Q07955 2.137 LCD, RRM Splicing NS Cáceres et al. (1997)  
25 RBM26 Q5T8P6 2.123 LCD, ZnF, RRM, coiled coil RNA binding NS HPA 
26 SF3A3 Q12874 2.077 LCD, ZnF, coiled coil Splicing NS Chiara et al. (1994)  
27 RBM8A Q9Y5S9 2.074 LCD, RRM Splicing NS HPA 
28 RBM27 Q9P2N5 2.062 LCD, RRM RNA binding NS HPA 
29 PRPF38A Q8NAV1 2.048 LCD, coiled coil Splicing NS This study 
30 SNRPA1 P09661 2.038 LCD, LRRcap Splicing NS HPA 
31 PUF60 Q9UHX1 2.030 LCD, RRM Splicing NP HPA 
32 SAP30BP Q9UHR5 1.998 LCD Transcription NP Li et al. (2004)  
33 PRPF6 O94906 1.996 LCD, coiled coil, HAT Splicing NS HPA 
34 RNPS1 Q15287 1.993 LCD, RRM Splicing NS Trembley et al. (2005)  
35 AURKA O14965 1.982 S_TKc Kinase NP HPA 
36 RBM17 Q96I25 1.979 LCD, G patch, RRM Splicing NP HPA 
37 LSM3 P57743 1.948 Sm Splicing NP HPA 
38 SF3B1 O75533 1.946 LCD, coiled coil Splicing NS HPA 
39 RPRD1B Q9NQG5 1.942 RPR, coiled coil Transcription NP HPA 
40 CAPRIN1 Q14444 1.931 LCD, coiled coil RNA-binding Cy Solomon et al. (2007)  
41 PRPF4 O43172 1.931 LCD, SFM, WD40 Splicing NS HPA 
42 CDC5L Q99459 1.915 LCD, SANT, coiled coil Splicing NS Burns et al. (1999)  
43 SRSF7 Q16629 1.909 LCD Splicing NP HPA 
44 PRPF8 Q6P2Q9 1.906 LCD, RRM, ZnF Splicing NS Malinová et al. (2017)  
45 SNW1 Q13573 1.906 LCD Splicing NP HPA, Zhang et al. (2003)  
46 DHX15 O43143 1.886 LCD, DEXDc, HELICc Splicing NS HPA 
47 XAB2 Q9HCS7 1.882 LCD, HAT Splicing NP HPA, Onyango et al. (2016)  
48 TLE3 Q04726 1.877 LCD, WD40, coiled coil Transcription NP HPA 
49 KIAA1429 Q69YN4 1.876 LCD Splicing NS Horiuchi et al. (2013)  
50 CHERP Q8IWX8 1.867 LCD, G_patch, SWAP Splicing NS Sasaki-Osugi et al. (2013)  
51 SART1 O43290 1.865 LCD, coiled coil Splicing NS HPA 
52 PSME3 P61289 1.859  Misc. NS Baldin et al. (2008)  
#Gene nameEntry IDSPK-CEN ratioProtein domainsGO annotated processLocalization (IF)IF references
1 SON P18583 4.918 LCD, DRBM, G patch Splicing NS HPA, Saitoh et al. (2004)  
2 SRRM2 Q9UQ35 4.642 LCD, coiled coil Splicing NS HPA, Mintz et al. (1999)  
3 PRPF40A O75400 3.050 LCD, coiled coil, WW Splicing NS HPA 
4 RBM25 P49756 2.722 LCD, RRM, coiled coil, PWI Splicing NS HPA, Zhou et al. (2008)  
5 ZNF207 O43670 2.564 LCD, ZnF Transcription NS Rai et al. (2018), this study 
6 LUC7L2 Q9Y383 2.413 LCD, coiled coil Splicing NS Howell et al. (2007)  
7 SRRM1 Q8IYB3 2.409 LCD, PWI Splicing NS HPA 
8 WTAP Q15007 2.373 LCD, coiled coil Splicing NS HPA, Little et al. (2000)  
9 ZC3H14 Q6PJT7 2.362 LCD, ZnF Poly(A) binding NS HPA, Leung et al. (2009)  
10 ACIN1 Q9UKV3 2.341 LCD, coiled coil, RRM, SAP Splicing NS Saitoh et al. (2004)  
11 SAP18 O00422 2.328 LCD Splicing NS Singh et al. (2010)  
12 DDX46 Q7L014 2.299 LCD, DEXD, HELICc Splicing NS HPA, Will et al. (2002)  
13 TRA2A Q13595 2.295 LCD, RRM Splicing NS Platt et al. (2015)  
14 SRSF2 Q01130 2.284 LCD, RRM Splicing NS Fu and Maniatis (1990)  
15 DDX23 Q9BUQ8 2.263 LCD, coiled coil, DEXDc, HELICc Splicing NP HPA 
16 CDK12 Q9NYV4 2.247 LCD, S_TKc Transcription NS Ko et al. (2001)  
17 PRPF4B Q13523 2.239 LCD, coiled coil Splicing NS HPA 
18 LUC7L3 O95232 2.238 LCD, coiled coil Splicing NS HPA, Umehara et al. (2003)  
19 MFAP1 P55081 2.230 LCD, coiled coil Splicing NS This study, Salas-Armenteros et al. (2019)  
20 SF3A1 Q07955 2.227 LCD, RRM Splicing NS HPA, Huang et al. (2011)  
21 SF3B2 Q13435 2.205 LCD, coiled coil Splicing NS HPA, Terada and Yasuda (2006)  
22 RBM39 Q14498 2.200 LCD, RRM Splicing NS HPA, Imai et al. (1993)  
23 RBM10 P98175 2.181 LCD, RRM, ZnF, G patch Splicing NS HPA, Inoue et al. (2008)  
24 SRSF1 Q07955 2.137 LCD, RRM Splicing NS Cáceres et al. (1997)  
25 RBM26 Q5T8P6 2.123 LCD, ZnF, RRM, coiled coil RNA binding NS HPA 
26 SF3A3 Q12874 2.077 LCD, ZnF, coiled coil Splicing NS Chiara et al. (1994)  
27 RBM8A Q9Y5S9 2.074 LCD, RRM Splicing NS HPA 
28 RBM27 Q9P2N5 2.062 LCD, RRM RNA binding NS HPA 
29 PRPF38A Q8NAV1 2.048 LCD, coiled coil Splicing NS This study 
30 SNRPA1 P09661 2.038 LCD, LRRcap Splicing NS HPA 
31 PUF60 Q9UHX1 2.030 LCD, RRM Splicing NP HPA 
32 SAP30BP Q9UHR5 1.998 LCD Transcription NP Li et al. (2004)  
33 PRPF6 O94906 1.996 LCD, coiled coil, HAT Splicing NS HPA 
34 RNPS1 Q15287 1.993 LCD, RRM Splicing NS Trembley et al. (2005)  
35 AURKA O14965 1.982 S_TKc Kinase NP HPA 
36 RBM17 Q96I25 1.979 LCD, G patch, RRM Splicing NP HPA 
37 LSM3 P57743 1.948 Sm Splicing NP HPA 
38 SF3B1 O75533 1.946 LCD, coiled coil Splicing NS HPA 
39 RPRD1B Q9NQG5 1.942 RPR, coiled coil Transcription NP HPA 
40 CAPRIN1 Q14444 1.931 LCD, coiled coil RNA-binding Cy Solomon et al. (2007)  
41 PRPF4 O43172 1.931 LCD, SFM, WD40 Splicing NS HPA 
42 CDC5L Q99459 1.915 LCD, SANT, coiled coil Splicing NS Burns et al. (1999)  
43 SRSF7 Q16629 1.909 LCD Splicing NP HPA 
44 PRPF8 Q6P2Q9 1.906 LCD, RRM, ZnF Splicing NS Malinová et al. (2017)  
45 SNW1 Q13573 1.906 LCD Splicing NP HPA, Zhang et al. (2003)  
46 DHX15 O43143 1.886 LCD, DEXDc, HELICc Splicing NS HPA 
47 XAB2 Q9HCS7 1.882 LCD, HAT Splicing NP HPA, Onyango et al. (2016)  
48 TLE3 Q04726 1.877 LCD, WD40, coiled coil Transcription NP HPA 
49 KIAA1429 Q69YN4 1.876 LCD Splicing NS Horiuchi et al. (2013)  
50 CHERP Q8IWX8 1.867 LCD, G_patch, SWAP Splicing NS Sasaki-Osugi et al. (2013)  
51 SART1 O43290 1.865 LCD, coiled coil Splicing NS HPA 
52 PSME3 P61289 1.859  Misc. NS Baldin et al. (2008)  

Also displayed are the annotated protein domains, GO Modular Architecture Research Tool SMART, HPA, the UniProt knowledgebase (https://www.uniprot.org/), as well as available literature. IF (immunofluorescence or fluorescent protein signal); FDEXD (DExD/H-box helicase domain); DEXDc (DEAD-like helicases superfamily); HELICc (helicase superfamily c-terminal domain); HAT (Half-A-TPR repeats); DRBM (double-stranded RNA-binding motif); LRRcap (LRR-containing proteins); ZnF (zinc finger); S_TKc (Serine/Threonine protein kinases, catalytic domain). NP, nucleoplasm; NS, nuclear speckle,

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