Table 2.
Tissue architecture, nuclear migration kinetics, and shape change parameters that differ between straight and curved neuroepithelial tissues
ParameterStraight tissuesCurved tissuesP values
HindbrainMHBSRetinaMHBCHB-MHBSR-MHBCHB-RMHBS-MHBC
Cell length (μm) 45.32 ± 4.19 38.27 ± 4.6 46.13 ± 5.13 41.54 ± 4.6 0.1017 0.0053 0.5780 0.0872 
Apical-to-basal footprint ratio 1.25 ± 0.47 1.46 ± 0.76 2.32 ± 0.76 2.32 ± 1.28 0.1312 0.2617 <0.0001 <0.0001 
Duration of apical migration (min) 13.3 ± 4.5  11.3 ± 2.5 21.9 ± 7.9 17.8 ± 6.6 0.3540 0.2457 0.0052 0.0326 
Mean instantaneous velocity (μm/min) 0.63 ± 0.74 0.66 ± 0.68 0.32 ± 0.77 0.36 ± 0.52 0.9423 0.7831 <0.0001 0.0038 
Directionality ratio 0.63 ± 0.06 0.67 ± 0.01 0.36 ± 0.07 0.53 ± 0.01 – – – – 
Normalized nuclear aspect ratio (G2) 0.01 ± 0.16 0.12 ± 0.13 0.17 ± 0.25 0.24 ± 0.31 <0.0001 0.0324 0.0001 0.0221 
Variance of the normalized nuclear aspect ratio (G2) 0.026 0.017 0.063 0.096 0.0402 0.0007 0.0001 <0.0001 

Values shown represent mean ± SD. All P values were calculated using Mann-Whitney test, except for the variances of the normalized nuclear aspect ratio, for which Levene’s test was used. –, not applicable.

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