Table 3.
Effect of G15S expression and tsr knockdown on dendrites
DescriptionAverage ± SD (sample number)
ControlAct42AG15Stsr-RNAi
Dendrites / c4ddaC (number) 187 ± 20 (n = 12) 163 ± 37 (n = 9) 105 ± 18 (n = 10) 100 ± 20 (n = 10) 
Dendrites / c3ddaF (number) 263 ± 51 (n = 15) 239 ± 41 (n = 9) 64 ± 12 (n = 10) 142 ± 21 (n = 10) 
Dendrites / c3ddaA (number) 329 ± 50 (n = 10) 331 ± 60 (n = 9) 72 ± 19 (n = 9) 181± 48 (n = 8) 
Dendrites / c1ddaE (MARCM; number) 25 ± 6.6 (n = 11) NDa ND 19.6 ± 2.9 (n = 10) 
Dendrites / c1ddaE (number) 23.8 ± 2.7 (n = 13) 22.2 ± 3.1 (n = 8) 12.6 ± 1.8 (n = 9) ND 
LifeAct intensity in proximal dendrites (AU) 0.4 ± 0.1 (n = 9) 0.4 ± 0.1 (n = 6) 0.3 ± 0.2 (n = 8) 0.4 ± 0.2 (n = 7) 
LifeAct intensity in terminal dendrites (AU) 0.5 ± 0.2 (n = 9) 0.5 ± 0.1 (n = 6) 0.3 ± 0.1 (n = 10) 0.6 ± 0.3 (n = 7) 
Dendrites with actin blobs (%) 97.4 (n = 39) 93.3 (n = 15) 55.2 (n = 29) 67.9 (n = 28) 
Actin blobs in terminal dendrites (in 10 µm) 3.3 ± 2.3 (n = 39) 2.8 ± 1.8 (n = 15) 0.5 ± 0.6 (n = 29) 0.6 ± 0.6 (n = 28) 
Dendrites with splitting events (%) 42.1 (n = 38) 33.3 (n = 15) 7.1 (n = 14) 0 (n = 28) 
Velocity in terminal dendrites (μm/min) 1.3 ± 0.4 (n = 94) 1.4 ± 0.5 (n = 61) 1.2 ± 0.4 (n = 23) 1.1 ± 0.5 (n = 26) 
Actin blob size (μm) 3.1 ± 1.1 (n = 68) 3.1 ± 1.4 (n = 22) 1.8 ± 0.8 (n = 20) 2.0 ± 0.9 (n = 23) 
New dendrites (in 104 μm212.5 ± 7.4 (n = 14) 12.2 ± 8.8 (n = 6) 1.9 ± 2.3 (n = 12) 3.1 ± 4.5 (n = 11) 
New dendrites with prelocalization (%) 83.0 (n = 53) 78.9 (n = 19) 33.3 (n = 18) 47.4 (n = 19) 
Normalized LifeAct intensity in new dendrites (AU) 1.0 ± 0.4 (n = 30) 1.0 ± 0.2 (n = 18) 0.5 ± 0.3 (n = 21) 0.6 ± 0.2 (n = 22) 
New dendrite growth in 5 min (μm) 3.8 ± 1.9 (n = 25) 4.0 ± 1.4 (n = 20) 2.5 ± 0.9 (n = 14) 2.3 ± 0.9 (n = 13) 
Existing dendrite extension in 10 min (μm) 3.3 ± 0.5 (n = 81) 3.4 ± 1.3 (n = 20) 1.1 ± 0.2 (n = 48) 1.9 ± 0.5 (n = 62) 
Existing dendrite retraction in 10 min (μm) 3.1 ± 0.9 (n = 81) 3.8 ± 0.7 (n = 20) 1.3 ± 0.4 (n = 48) 2.0 ± 0.5 (n = 62) 
DescriptionAverage ± SD (sample number)
ControlAct42AG15Stsr-RNAi
Dendrites / c4ddaC (number) 187 ± 20 (n = 12) 163 ± 37 (n = 9) 105 ± 18 (n = 10) 100 ± 20 (n = 10) 
Dendrites / c3ddaF (number) 263 ± 51 (n = 15) 239 ± 41 (n = 9) 64 ± 12 (n = 10) 142 ± 21 (n = 10) 
Dendrites / c3ddaA (number) 329 ± 50 (n = 10) 331 ± 60 (n = 9) 72 ± 19 (n = 9) 181± 48 (n = 8) 
Dendrites / c1ddaE (MARCM; number) 25 ± 6.6 (n = 11) NDa ND 19.6 ± 2.9 (n = 10) 
Dendrites / c1ddaE (number) 23.8 ± 2.7 (n = 13) 22.2 ± 3.1 (n = 8) 12.6 ± 1.8 (n = 9) ND 
LifeAct intensity in proximal dendrites (AU) 0.4 ± 0.1 (n = 9) 0.4 ± 0.1 (n = 6) 0.3 ± 0.2 (n = 8) 0.4 ± 0.2 (n = 7) 
LifeAct intensity in terminal dendrites (AU) 0.5 ± 0.2 (n = 9) 0.5 ± 0.1 (n = 6) 0.3 ± 0.1 (n = 10) 0.6 ± 0.3 (n = 7) 
Dendrites with actin blobs (%) 97.4 (n = 39) 93.3 (n = 15) 55.2 (n = 29) 67.9 (n = 28) 
Actin blobs in terminal dendrites (in 10 µm) 3.3 ± 2.3 (n = 39) 2.8 ± 1.8 (n = 15) 0.5 ± 0.6 (n = 29) 0.6 ± 0.6 (n = 28) 
Dendrites with splitting events (%) 42.1 (n = 38) 33.3 (n = 15) 7.1 (n = 14) 0 (n = 28) 
Velocity in terminal dendrites (μm/min) 1.3 ± 0.4 (n = 94) 1.4 ± 0.5 (n = 61) 1.2 ± 0.4 (n = 23) 1.1 ± 0.5 (n = 26) 
Actin blob size (μm) 3.1 ± 1.1 (n = 68) 3.1 ± 1.4 (n = 22) 1.8 ± 0.8 (n = 20) 2.0 ± 0.9 (n = 23) 
New dendrites (in 104 μm212.5 ± 7.4 (n = 14) 12.2 ± 8.8 (n = 6) 1.9 ± 2.3 (n = 12) 3.1 ± 4.5 (n = 11) 
New dendrites with prelocalization (%) 83.0 (n = 53) 78.9 (n = 19) 33.3 (n = 18) 47.4 (n = 19) 
Normalized LifeAct intensity in new dendrites (AU) 1.0 ± 0.4 (n = 30) 1.0 ± 0.2 (n = 18) 0.5 ± 0.3 (n = 21) 0.6 ± 0.2 (n = 22) 
New dendrite growth in 5 min (μm) 3.8 ± 1.9 (n = 25) 4.0 ± 1.4 (n = 20) 2.5 ± 0.9 (n = 14) 2.3 ± 0.9 (n = 13) 
Existing dendrite extension in 10 min (μm) 3.3 ± 0.5 (n = 81) 3.4 ± 1.3 (n = 20) 1.1 ± 0.2 (n = 48) 1.9 ± 0.5 (n = 62) 
Existing dendrite retraction in 10 min (μm) 3.1 ± 0.9 (n = 81) 3.8 ± 0.7 (n = 20) 1.3 ± 0.4 (n = 48) 2.0 ± 0.5 (n = 62) 
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