Table 1. Summary of parameters and... | Rockefeller University Press

Table 1.

Summary of parameters and variables used in the finite element simulations

Parameter	Definition	Parameter values
E, ν	Elastic moduli of the cell	E = 10 kPa, ν = 0.49
Es	Elastic modulus of the series element	2 MPa
σ_c₀	Isometric tension of contraction	Neonate: 20 kPa; stem cell: 10 kPa
γ	Strain rate constant	Neonate: −1.0 s⁻¹; Stem cell: −0.5 s⁻¹
k_max	Maximal value of cell substrate linkage constant	0.7 kPa/µm
k_cs(x,y)	Cell substrate linkage constant	0.0 to ∼0.7 kPa/µm
k_cc	Spring constant of cell substrate adhesion	0.01 to ∼0.05 kPa
ρ_max	Maximal density of bound integrin	400 µm⁻²
ρ(x,y)	Density of bound integrin	0 to ∼400 µm⁻²
T₀	Traction stress threshold	0.65 to ∼1.0 kPa
σ_c	Contractile stress	NA
σ_x, σ_y, τ_xy	Components of the stress tensor	NA
u_x, u_y	Components of the displacement vector	NA
ε_x, ε_y, ε_xy	Components of the strain tensor	NA
T_x, T_y	Components of the traction stress	NA

Parameter	Definition	Parameter values
E, ν	Elastic moduli of the cell	E = 10 kPa, ν = 0.49
Es	Elastic modulus of the series element	2 MPa
σ_c₀	Isometric tension of contraction	Neonate: 20 kPa; stem cell: 10 kPa
γ	Strain rate constant	Neonate: −1.0 s⁻¹; Stem cell: −0.5 s⁻¹
k_max	Maximal value of cell substrate linkage constant	0.7 kPa/µm
k_cs(x,y)	Cell substrate linkage constant	0.0 to ∼0.7 kPa/µm
k_cc	Spring constant of cell substrate adhesion	0.01 to ∼0.05 kPa
ρ_max	Maximal density of bound integrin	400 µm⁻²
ρ(x,y)	Density of bound integrin	0 to ∼400 µm⁻²
T₀	Traction stress threshold	0.65 to ∼1.0 kPa
σ_c	Contractile stress	NA
σ_x, σ_y, τ_xy	Components of the stress tensor	NA
u_x, u_y	Components of the displacement vector	NA
ε_x, ε_y, ε_xy	Components of the strain tensor	NA
T_x, T_y	Components of the traction stress	NA