Table 4. p53 status in K243R/ tumors... | Rockefeller University Press

Table 4.

p53 status in K243R/+ tumors

Tumor	Sex	Age	Mutation^a	Mutant^a	Effect	p_domain^b
		wk
Hepatocellular carcinoma 1	Male	61	c.163ins_T	STOP 55	Insertion	TAD
Hepatocellular carcinoma 2	Male	117	c.242C>Tc.301C>T	p.A81Vp.Q101X	MissenseNonsense	PRDDBD
Sarcoma 1	Male	69	c.163ins_Tc.296ins_A	STOP 55STOP 99	InsertionInsertion	TADDBD
Sarcoma 2	Female	122	c.296ins_Ac.467C>T	STOP 99p.A156V	InsertionMissense	DBDDBD
B cell lymphoma 1	Female	62	c.359-365del7	STOP 128	Deletion	DBD
B cell lymphoma 2	Female	119	c.109T>C;980T>Cc.429G>A	p.S37P;L327Pp.W143X	MissenseNonsense	TAD, 4DDBD
B cell lymphoma 3	Female	139	c.443C>T	p.P148L	Missense	DBD
Leukemia 1	Female	57	c.1064A>Gc.841A>G	p.E355Gp.T281A	MissenseMissense	DBDDBD

Tumor	Sex	Age	Mutation^a	Mutant^a	Effect	p_domain^b
		wk
Hepatocellular carcinoma 1	Male	61	c.163ins_T	STOP 55	Insertion	TAD
Hepatocellular carcinoma 2	Male	117	c.242C>Tc.301C>T	p.A81Vp.Q101X	MissenseNonsense	PRDDBD
Sarcoma 1	Male	69	c.163ins_Tc.296ins_A	STOP 55STOP 99	InsertionInsertion	TADDBD
Sarcoma 2	Female	122	c.296ins_Ac.467C>T	STOP 99p.A156V	InsertionMissense	DBDDBD
B cell lymphoma 1	Female	62	c.359-365del7	STOP 128	Deletion	DBD
B cell lymphoma 2	Female	119	c.109T>C;980T>Cc.429G>A	p.S37P;L327Pp.W143X	MissenseNonsense	TAD, 4DDBD
B cell lymphoma 3	Female	139	c.443C>T	p.P148L	Missense	DBD
Leukemia 1	Female	57	c.1064A>Gc.841A>G	p.E355Gp.T281A	MissenseMissense	DBDDBD

Mutation nomenclatures follow the Human Genome Variation Society recommendations. c, coding sequence; ins, insertion; del, deletion; p, protein sequence. p53 status was determined by the nucleotide sequencing of four to five clones derived from each tumor.

Protein domain with mutation indicated. TAD, transactivation domain; PRD, proline-rich domain; DBD, DNA-binding domain; 4D, tetramerization domain.

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