Tumor spectrum and analysis
| Tumor types | BubR1K243R/+ (n = 121) | BubR1+/+ (n = 41) |
| Malignant tumors | 28 (23.1%) | 2 (4.8%) |
| Malignant solid tumors | 13 (10.7%) | 1 (2.4%) |
| Hepatocellular carcinoma | 6 (5.0%) | |
| Sarcomaa | 4 (3.3%) | 1 (2.4%) |
| Adenocarcinomab | 2 (1.7%) | |
| Other cancerc | 1 (0.8%) | |
| Hematologic malignancies | 15 (12.4%) | 1(2.4%) |
| Megakaryocyte leukemia | 1 (0.8%) | |
| B cell lymphoma | 11 (9.1%) | 1 (2.4%) |
| Metastatic lymphoma/leukemia | 3 (2.5%) | |
| Benign tumorsd | 18 (14.9%) | |
| Total tumor incidence | 46 (38.0%) | 2 (4.8%) |
| Tumor types | BubR1K243R/+ (n = 121) | BubR1+/+ (n = 41) |
| Malignant tumors | 28 (23.1%) | 2 (4.8%) |
| Malignant solid tumors | 13 (10.7%) | 1 (2.4%) |
| Hepatocellular carcinoma | 6 (5.0%) | |
| Sarcomaa | 4 (3.3%) | 1 (2.4%) |
| Adenocarcinomab | 2 (1.7%) | |
| Other cancerc | 1 (0.8%) | |
| Hematologic malignancies | 15 (12.4%) | 1(2.4%) |
| Megakaryocyte leukemia | 1 (0.8%) | |
| B cell lymphoma | 11 (9.1%) | 1 (2.4%) |
| Metastatic lymphoma/leukemia | 3 (2.5%) | |
| Benign tumorsd | 18 (14.9%) | |
| Total tumor incidence | 46 (38.0%) | 2 (4.8%) |
Sarcomas included smooth muscle sarcoma (n = 2), endometrial stromal sarcoma (n = 1), and angiosarcoma (n = 1) in K243R/+ mice. A single fibrosarcoma was found in the WT.
Adenocarcinomas included lung adenocarcinoma (n = 1) and rectal adenocarcinoma (n = 1) in K243R/+.
Other cancer included skin cancer.
Benign tumors included simple cysts in the genital tract (n = 10), hemangioma (n = 5), epidermal cyst (n = 1), acrochordon (n = 1), and mesenchymal fibroma (n = 1).