Table 1.
The hemodynamic parameters in TNF-α–challenged WT and DREAM KO mice
GenotypeWBC (cells/μl)% of neutrophilsDiameter of venules (μm)Blood flow rate (μl−6/s)
WT 3,100 ± 750 39 ± 6 33.5 ± 4 426 ± 105 
DREAM KO 4,300 ± 1,220 45 ± 9 35.2 ± 4 652 ± 129* 
GenotypeWBC (cells/μl)% of neutrophilsDiameter of venules (μm)Blood flow rate (μl−6/s)
WT 3,100 ± 750 39 ± 6 33.5 ± 4 426 ± 105 
DREAM KO 4,300 ± 1,220 45 ± 9 35.2 ± 4 652 ± 129* 

Mice were treated with intrascrotal injection of TNF-α, followed by intravital microscopy as described in Fig. 1. After 1 h imaging, fluorescently labeled microspheres (diameter: 200 nm) were injected into mice, and the centerline velocity was calculated to assess blood flow rates. Data represent the mean ± SD (n = 12 venules in 6 mice per group). *, P < 0.05 versus WT mice after Student’s t test. WBC, white blood cells.

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