| . | Patient 1 . | Patient 2 . | Patient 3 . |
|---|---|---|---|
| Gender | Male | Male | Female |
| Age (yr) | 63 | 58 | 49 |
| Medical history | Hypertension (no treatment) | Obesity | Renal transplantation (immunosuppressive therapy) |
| Hypertension | Type 1 diabetes | ||
| Sleep apnea syndrome | Hypertension | ||
| Pneumonia (2017) | Pulmonary embolism (2003) | ||
| Onset of illness | Day 0: Dyspnea and fever | Day 0: Diarrhea, asthenia | Day 0: Fever, dyspnea, cough, sputum |
| Day 16: Chills and dyspnea | |||
| SARS-CoV-2 PCR test positive | No SARS-CoV-2 PCR test | Day 1: Nasal SARS-CoV-2 PCR test positive | |
| Emergency department admission | Day 10: Worsening dyspnea → patient sedated and ventilated | ||
| ICU admission | Day 10: Acute respiratory distress and left myocardial failure | Day 18: Acute respiratory distress and fever → patient sedated and ventilated | Day 3: Dyspnea; mechanical ventilation |
| Day 5: Moderate acute respiratory distress syndrome; kidney failure | |||
| Medical course | Day 14: Difficulty waking the patient after cessation of sedation = areactive encephalopathy | Resuscitated hypoxic cardiac arrest due to aspiration during initial care | Difficult ventilator withdrawal |
| Compressive pneumothorax; refractory cardiac arrests | Day 16: Bacterial pneumoniae; transfer to the rehabilitation service | ||
| No SARS-CoV-2 PCR test during hospitalization | Day 19: Acute respiratory distress and kidney failure → transfer to ICU | ||
| Brain imaging | Day 32: Brain MRI; multiple diffuse micro bleedings (subcortical and deep regions) | No brain imaging | No brain imaging |
| Death | Day 43 | Day 19 (after 6–12 h of hospital medical care) | Day 27 |
| Postmortem SARS-CoV-2 PCR test on lungs | Positive | Positive | Positive |
| . | Patient 1 . | Patient 2 . | Patient 3 . |
|---|---|---|---|
| Gender | Male | Male | Female |
| Age (yr) | 63 | 58 | 49 |
| Medical history | Hypertension (no treatment) | Obesity | Renal transplantation (immunosuppressive therapy) |
| Hypertension | Type 1 diabetes | ||
| Sleep apnea syndrome | Hypertension | ||
| Pneumonia (2017) | Pulmonary embolism (2003) | ||
| Onset of illness | Day 0: Dyspnea and fever | Day 0: Diarrhea, asthenia | Day 0: Fever, dyspnea, cough, sputum |
| Day 16: Chills and dyspnea | |||
| SARS-CoV-2 PCR test positive | No SARS-CoV-2 PCR test | Day 1: Nasal SARS-CoV-2 PCR test positive | |
| Emergency department admission | Day 10: Worsening dyspnea → patient sedated and ventilated | ||
| ICU admission | Day 10: Acute respiratory distress and left myocardial failure | Day 18: Acute respiratory distress and fever → patient sedated and ventilated | Day 3: Dyspnea; mechanical ventilation |
| Day 5: Moderate acute respiratory distress syndrome; kidney failure | |||
| Medical course | Day 14: Difficulty waking the patient after cessation of sedation = areactive encephalopathy | Resuscitated hypoxic cardiac arrest due to aspiration during initial care | Difficult ventilator withdrawal |
| Compressive pneumothorax; refractory cardiac arrests | Day 16: Bacterial pneumoniae; transfer to the rehabilitation service | ||
| No SARS-CoV-2 PCR test during hospitalization | Day 19: Acute respiratory distress and kidney failure → transfer to ICU | ||
| Brain imaging | Day 32: Brain MRI; multiple diffuse micro bleedings (subcortical and deep regions) | No brain imaging | No brain imaging |
| Death | Day 43 | Day 19 (after 6–12 h of hospital medical care) | Day 27 |
| Postmortem SARS-CoV-2 PCR test on lungs | Positive | Positive | Positive |
ICU, intensive care unit; MRI, magnetic resonance imaging.