Table 1. EAE susceptibility of mice... | Rockefeller University Press

Table 1.

EAE susceptibility of mice included in this study

Genotype	Incidence	Disease onset	AUC
Constitutive KO mice
WT	22/22 (100%)	12.6 ± 4.2	39 ± 4^{^a}
Il-1r1^−/−	7/13 (54%)	25.0 ± 3.0	3 ± 2^{^a}
WT	12/13 (92%)	11.8 ± 0.6	60 ± 7
Il-1α^−/−	15/15 (100%)	12.2 ± 0.5	72 ± 7
WT	17/17 (100%)	13.4 ± 0.9	69 ± 9^{^b}
Il-1β^−/−	10/29 (34%)	31.7 ± 1.9	4.2 ± 2.3^{^b}
Bone marrow chimeric mice
WT → WT	8/8 (100%)	11.6 ± 0.4	89 ± 8
Il-1r1^−/− → WT	7/7 (100%)	12.0 ± 0.8	78 ± 11
WT → Il-1r1^−/−	6/6 (100%)	16.8 ± 1.4	52 ± 7
Il-1r1^−/− → Il-1r1^−/−	5/7 (71%)	17.0 ± 0.5	19 ± 5
WT → WT	15/15 (100%)	11.1 ± 0.4	79 ± 7
Il-1α^−/− → WT	15/15 (100%)	11.6 ± 0.4	72 ± 5
WT → Il-1α^−/−	15/15 (100%)	11.9 ± 0.2	83 ± 5
Il-1α^−/− → Il-1α^−/−	16/16 (100%)	11.8 ± 0.4	85 ± 5
WT → WT	15/15 (100%)	11.1 ± 0.4	79 ± 7
Il-1β^−/− → WT	7/11 (64%)	25.6 ± 3.0	9 ± 4
WT → Il-1β^−/−	14/14 (100%)	13.5 ± 0.8	66 ± 5
Il-1β^−/− → Il-1β^−/−	7/12 (58%)	25.0 ± 2.0	15 ± 5

Genotype	Incidence	Disease onset	AUC
Constitutive KO mice
WT	22/22 (100%)	12.6 ± 4.2	39 ± 4^a
Il-1r1^−/−	7/13 (54%)	25.0 ± 3.0	3 ± 2^a
WT	12/13 (92%)	11.8 ± 0.6	60 ± 7
Il-1α^−/−	15/15 (100%)	12.2 ± 0.5	72 ± 7
WT	17/17 (100%)	13.4 ± 0.9	69 ± 9^b
Il-1β^−/−	10/29 (34%)	31.7 ± 1.9	4.2 ± 2.3^b
Bone marrow chimeric mice
WT → WT	8/8 (100%)	11.6 ± 0.4	89 ± 8
Il-1r1^−/− → WT	7/7 (100%)	12.0 ± 0.8	78 ± 11
WT → Il-1r1^−/−	6/6 (100%)	16.8 ± 1.4	52 ± 7
Il-1r1^−/− → Il-1r1^−/−	5/7 (71%)	17.0 ± 0.5	19 ± 5
WT → WT	15/15 (100%)	11.1 ± 0.4	79 ± 7
Il-1α^−/− → WT	15/15 (100%)	11.6 ± 0.4	72 ± 5
WT → Il-1α^−/−	15/15 (100%)	11.9 ± 0.2	83 ± 5
Il-1α^−/− → Il-1α^−/−	16/16 (100%)	11.8 ± 0.4	85 ± 5
WT → WT	15/15 (100%)	11.1 ± 0.4	79 ± 7
Il-1β^−/− → WT	7/11 (64%)	25.6 ± 3.0	9 ± 4
WT → Il-1β^−/−	14/14 (100%)	13.5 ± 0.8	66 ± 5
Il-1β^−/− → Il-1β^−/−	7/12 (58%)	25.0 ± 2.0	15 ± 5

Two independent experiments were performed, and the pooled data are shown.

The area under the curve (AUC) was calculated up to day 28 after MOG_35–55 immunization.

The AUC was calculated only for the first experiment (WT mice, n = 7; Il-1β^−/− mice, n = 10), as mice included in the second experiment were killed at EAE onset + 1.

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