Blood counts of K3+/+ and K3−/− (moribund and healthy) chimeras
| Tests | K3+/+ chimera | K3−/− chimera (healthy) | K3−/− chimera (moribund) | P-value K3+/+ versus K3−/− (healthy) | Normal range |
| WBC (103/µl) | 9.9 ± 2.6 | 35.9 ± 16.8 | 13.9 ± 9.7 | <0.0001 | 1.8–10.7 |
| NE (103/µl) | 2.0 ± 0.9 | 17.6 ± 6.9 | 7.3 ± 6.5 | <0.0001 | 0.1–2.4 |
| LY (103/µl) | 7.6 ± 2.3 | 15.2 ± 8.9 | 5.1 ± 4.3 | 0.0016 | 0.9–9.3 |
| RBC (103/µl) | 8.6 ± 0.5 | 6.4 ± 1.0 | 1.6 ± 0.8 | <0.0001 | 6.36–9.42 |
| Hb (g/dl) | 13.0 ± 1.0 | 11.4 ± 1.5 | 3.8 ± 2.1 | 0.0024 | 11.0–15.1 |
| HCT (%) | 41.4 ± 2.3 | 35.0 ± 4.4 | 12.1 ± 6.6 | <0.0001 | 35.1–45.4 |
| MCV (fl) | 48.4 ± 0.9 | 54.6 ± 3.4 | 106.3 ± 120.9 | <0.0001 | 45.4–60.3 |
| MCH (pg) | 15.2 ± 0.6 | 17.8 ± 1.3 | 23.8 ± 5.2 | <0.0001 | 14.1–19.3 |
| PLT (103/µl) | 589.1 ± 141.9 | 739.0 ± 77.0 | 546.1 ± 238.6 | 0.0058 | 592–2,972 |
| Tests | P-value | Normal range | |||
| WBC (103/µl) | 9.9 ± 2.6 | 35.9 ± 16.8 | 13.9 ± 9.7 | <0.0001 | 1.8–10.7 |
| NE (103/µl) | 2.0 ± 0.9 | 17.6 ± 6.9 | 7.3 ± 6.5 | <0.0001 | 0.1–2.4 |
| LY (103/µl) | 7.6 ± 2.3 | 15.2 ± 8.9 | 5.1 ± 4.3 | 0.0016 | 0.9–9.3 |
| RBC (103/µl) | 8.6 ± 0.5 | 6.4 ± 1.0 | 1.6 ± 0.8 | <0.0001 | 6.36–9.42 |
| Hb (g/dl) | 13.0 ± 1.0 | 11.4 ± 1.5 | 3.8 ± 2.1 | 0.0024 | 11.0–15.1 |
| HCT (%) | 41.4 ± 2.3 | 35.0 ± 4.4 | 12.1 ± 6.6 | <0.0001 | 35.1–45.4 |
| MCV (fl) | 48.4 ± 0.9 | 54.6 ± 3.4 | 106.3 ± 120.9 | <0.0001 | 45.4–60.3 |
| MCH (pg) | 15.2 ± 0.6 | 17.8 ± 1.3 | 23.8 ± 5.2 | <0.0001 | 14.1–19.3 |
| PLT (103/µl) | 589.1 ± 141.9 | 739.0 ± 77.0 | 546.1 ± 238.6 | 0.0058 | 592–2,972 |
Values shown are the mean ± SD for 10–15 mice per genotype. WBC, white blood cell; NE, neutrophil; LY, lymphocyte; Hb, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; PLT, platelet.
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