Hemostasis and coagulation in Ir-CPI treated mice
| Inhibitors | aPTT | PT | Fibrinolysis | Bleeding effect (O.D. 450 nm) |
| s | s | min | ||
| PBS | 21.7 ± 2.4 | 25.4 ± 1.6 | 26 ± 9.7 | 8.6 ± 3.3 |
| Ir-CPI 1 mg/kg | 25.8 ± 5.8 | 25.1 ± 0.1 | 25 ± 11.3 | 7.6 ± 4.7 |
| Ir-CPI 10 mg/kg | 39.8 ± 5.2a | 27.5 ± 2.6 | 21 ± 4.6 | 14.5 ± 4.8 |
| LMWH 0.5 mg/kg | 47.5 ± 6.3a | 28.9 ± 3.3 | 23 ± 5.0 | >30.0 ± 0.0a |
| Inhibitors | aPTT | PT | Fibrinolysis | Bleeding effect (O.D. 450 nm) |
| s | s | min | ||
| PBS | 21.7 ± 2.4 | 25.4 ± 1.6 | 26 ± 9.7 | 8.6 ± 3.3 |
| Ir-CPI 1 mg/kg | 25.8 ± 5.8 | 25.1 ± 0.1 | 25 ± 11.3 | 7.6 ± 4.7 |
| Ir-CPI 10 mg/kg | 39.8 ± 5.2a | 27.5 ± 2.6 | 21 ± 4.6 | 14.5 ± 4.8 |
| LMWH 0.5 mg/kg | 47.5 ± 6.3a | 28.9 ± 3.3 | 23 ± 5.0 | >30.0 ± 0.0a |
Values are mean ± SEM (n = 5 for each test). LMWH, low molecular weight heparin.
P < 0.05, as compared to values observed in the control (PBS) by one-way ANOVA and Student’s t test–Newman-Keuls test.