Kinetic constants for Ir-CPI interactions with kallikrein, FXIa, FXIIa, and plasmin
| Ir-CPI–targeted factors | ka1 (1/Ms) | kd1 (1/s) | ka2 (1/s) | kd2 (1/s) | K (1/M) |
| Kallikrein | 3.49 ± 0.54 × 104 | 5.32 ± 0.92 × 10−2 | 8.34 ± 0.07 × 10−3 | 1.42 ± 0.11 × 10−3 | 4.51 ± 0.19 × 106 |
| FXIa | 2.31 ± 0.59 × 106 | 1.02 ± 0.51 × 10−1 | 2.98 ± 0.29 × 10−2 | 2.32 ± 0.28 × 10−3 | 3.83 ± 2.37 × 108 |
| FXIIa | 2.19 ± 0.06 × 105 | 9.46 ± 0.04 × 10−2 | 6.55 ± 0.66 × 10−1 | 1.05 ± 0.04 × 10−1 | 1.68 ± 1.10 × 108 |
| Plasmin | 9.00 ± 0.39 × 105 | 5.35 ± 1.33 × 10−3 | 5.82 ± 0.99 × 10−3 | 6.14 ± 0.96 × 10−3 | 3.30 ± 0.57 × 108 |
| Ir-CPI–targeted factors | ka1 (1/Ms) | kd1 (1/s) | ka2 (1/s) | kd2 (1/s) | K (1/M) |
| Kallikrein | 3.49 ± 0.54 × 104 | 5.32 ± 0.92 × 10−2 | 8.34 ± 0.07 × 10−3 | 1.42 ± 0.11 × 10−3 | 4.51 ± 0.19 × 106 |
| FXIa | 2.31 ± 0.59 × 106 | 1.02 ± 0.51 × 10−1 | 2.98 ± 0.29 × 10−2 | 2.32 ± 0.28 × 10−3 | 3.83 ± 2.37 × 108 |
| FXIIa | 2.19 ± 0.06 × 105 | 9.46 ± 0.04 × 10−2 | 6.55 ± 0.66 × 10−1 | 1.05 ± 0.04 × 10−1 | 1.68 ± 1.10 × 108 |
| Plasmin | 9.00 ± 0.39 × 105 | 5.35 ± 1.33 × 10−3 | 5.82 ± 0.99 × 10−3 | 6.14 ± 0.96 × 10−3 | 3.30 ± 0.57 × 108 |
Data represent the mean ± SD of three experiments.