Table 1. Permeabilized cardiac myocyte... | Rockefeller University Press

Table 1.

Permeabilized cardiac myocyte preparations

	Cardiac myocyte preparations	Length (µm)	Width (µm)	SL (µm)	Passive tension (kN·m⁻²)	Maximum force (µN)	Maximum tension (kN·m⁻²)	Maximal k_tr (s⁻¹)	pCa for half-max. tension	Relative tension half-max. pCa
Rat (N = 5)	n = 5	144 ± 10	26 ± 3	2.23 ± 0.01	1.2 ± 0.3	17.2 ± 3.0	50 ± 10	9.83 ± 0.42	5.90 ± 0.06	0.44 ± 0.02
cMyBP-C WT (N = 5) + MAVA	n = 5	117 ± 9	30 ± 3	2.27 ± 0.04	1.0 ± 0.2	16.6 ± 4.1 10.7 ± 2.9*	33 ± 3 20 ± 2**	12.30 ± 2.10 9.01 ± 1.57*	5.94 ± 0.02 5.74 ± 0.02**	0.45 ± 0.05 0.50 ± 0.02
cMyBP-C KO (N = 5) + MAVA	n = 5	120 ± 14	27 ± 2	2.23 ± 0.01	1.3 ± 0.2	16.7 ± 2.2 10.6 ± 1.5**	45 ± 7 29 ± 6**	14.25 ± 2.17 8.77 ± 1.28*	5.88 ± 0.02 5.68 ± 0.05**	0.39 ± 0.02 0.55 ± 0.02***

	Cardiac myocyte preparations	Length (µm)	Width (µm)	SL (µm)	Passive tension (kN·m⁻²)	Maximum force (µN)	Maximum tension (kN·m⁻²)	Maximal k_tr (s⁻¹)	pCa for half-max. tension	Relative tension half-max. pCa
Rat (N = 5)	n = 5	144 ± 10	26 ± 3	2.23 ± 0.01	1.2 ± 0.3	17.2 ± 3.0	50 ± 10	9.83 ± 0.42	5.90 ± 0.06	0.44 ± 0.02
cMyBP-C WT (N = 5)+ MAVA	n = 5	117 ± 9	30 ± 3	2.27 ± 0.04	1.0 ± 0.2	16.6 ± 4.110.7 ± 2.9*	33 ± 320 ± 2**	12.30 ± 2.109.01 ± 1.57*	5.94 ± 0.025.74 ± 0.02**	0.45 ± 0.050.50 ± 0.02
cMyBP-C KO (N = 5) + MAVA	n = 5	120 ± 14	27 ± 2	2.23 ± 0.01	1.3 ± 0.2	16.7 ± 2.2 10.6 ± 1.5**	45 ± 7 29 ± 6**	14.25 ± 2.17 8.77 ± 1.28*	5.88 ± 0.02 5.68 ± 0.05**	0.39 ± 0.02 0.55 ± 0.02***

Values are means ± SEM; *P < 0.05, ***P < 0.01 ***P < 0.001 cMyBP-C before mavacamten (MAVA) versus with MAVA via paired t test.