Average values for spontaneous CL in numerical models with different CRU distributions in basal state and in response to βAR stimulation (see respective plots in Fig. 9 A)
| Cycle length | Square lattice | SD = 0.25, µm | SD = 0.5, µm | SD = 0.75, µm | Uniformly random |
|---|---|---|---|---|---|
| Basal state, ms | 461.3167 | 410.225 | 367.36 | 346.2667 | 318.1686 |
| βAR stimulation, ms | 290.5686 | 282.0629 | 267.9727 | 262.6303 | 265.9219 |
| Change, ms | 170.7481 | 128.1621 | 99.38727 | 83.63636 | 52.2467 |
| Change, % | 37.01321 | 31.24191 | 27.05446 | 24.15374 | 16.42107 |
| Cycle length | Square lattice | SD = 0.25, µm | SD = 0.5, µm | SD = 0.75, µm | Uniformly random |
|---|---|---|---|---|---|
| Basal state, ms | 461.3167 | 410.225 | 367.36 | 346.2667 | 318.1686 |
| βAR stimulation, ms | 290.5686 | 282.0629 | 267.9727 | 262.6303 | 265.9219 |
| Change, ms | 170.7481 | 128.1621 | 99.38727 | 83.63636 | 52.2467 |
| Change, % | 37.01321 | 31.24191 | 27.05446 | 24.15374 | 16.42107 |
SD provides the deviating from the square lattice positions, following Gaussian distribution with SD. (1) CRUs placed exactly at the nodes of a square lattice of 1.44 µm size. (2) CRUs slightly deviating from the square lattice positions, following Gaussian distribution with SD = 0.25 µm. (3) CRUs moderately deviating from square lattice positions, following Gaussian distribution with SD = 0.5 µm. (4) CRUs strongly deviating from the square lattice positions, following Gaussian distribution with SD = 0.75 µm. (5) Uniformly random CRU positions excluding overlap. CL was measured for the time interval from 5 to 16.5 s (when simulations ended). All model simulations began with identical initial conditions and the initial 5 s period was omitted from the analysis to allow the system to reach a balance (see our original intervalograms in Fig. S3).
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