Table 1. Immunophenotyping of the... | Rockefeller University Press

Table 1.

Immunophenotyping of the patient at different years of age

	Patient		Ref.	Patient	Ref.	Patient		Ref.
Age at evaluation (years)	4	6	3–6	10	7–12	14	17	13–18
T lymphocytes
CD3⁺ (/μl)	1,304	1,043	1,400–3,700	1,260	1,200–2,600	916	672	1,000–2,200
CD3⁺CD4⁺ (/μl)	775	575	700–2,200	780	650–1,500	476	365	530–1,300
Naive CD4⁺ CD45RA⁺ %	NA	24.5	53–86	NA	46–77	39	40	33–66
Memory CD4⁺ CD45RO⁺ %	NA	24.5	9–26	NA	13–30	29.5	35	18–38
T reg CD4⁺ CD25⁺CD127^LOW %	NA	4.6	4.2–12.5	NA	4.2–12.5	NA	NA	4.2–10.5
CD8⁺ (/μl)	454	378	490–1,300	490	370–1,100	297	221	330–920
Naive CD8⁺ CCR7⁺CD45RA⁺ %	NA	69.7	52–68	NA	40–75	51	48	52–68
Central memory CD8⁺ CCR7⁺CD45RA⁻ %	NA	1	12–30	NA	13–37	4	5	10–31
Effector memory CD8⁺CCR7⁻CD45RA⁻ %	NA	10.6	1.5–13	NA	1.5–15	29	28	2.3–15
Terminal effector CD8⁺CCR7⁻CD45RA⁺ %	NA	39.6	1.7–24	NA	2–21	16	19	5–31
Natural killer cells
CD3⁻CD56⁺ (/μl)	114	91	130–720	120	100–480	NA	NA	70–480
B lymphocytes
CD19⁺ (/μl)	397	161	273–860	350	219–509	226	163	193–628
Naive B cells CD27⁻IgD⁺ %	NA	75	59.7–88.4	NA	58.5–84.6	89	79	61.6–87.4
Memory B cells CD27⁺ %	NA	NA	8.1–33.3	NA	9–35	7	18	14.6–26.6
Unswitched memory CD27⁺IgD⁺ %	NA	12	3.1–18	NA	3–21.1	4.4	12	2.6–13.4
Switched memory CD27⁺IgD⁻ %	NA	10	2.9–17.4	NA	4.4–20.5	3	6	4–21.2
Transitional CD24⁺⁺CD38⁺⁺ %	NA	12	5.4–9.2	NA	4.5–9.2	3	7	3.9–7.8
Plasmablast CD24⁻CD38⁺⁺ %	NA	0	0.8–2.7	NA	0.7–3.5	0.6	0.4	0.3–1.7
CD19⁺ CD21⁻CD38⁻ %	NA	2	1.8–5.2	NA	0.9–3.5	2	3	0.9–3.3

	Patient		Ref.	Patient	Ref.	Patient		Ref.
Age at evaluation (years)	4	6	3–6	10	7–12	14	17	13–18
T lymphocytes
CD3⁺ (/μl)	1,304	1,043	1,400–3,700	1,260	1,200–2,600	916	672	1,000–2,200
CD3⁺CD4⁺ (/μl)	775	575	700–2,200	780	650–1,500	476	365	530–1,300
Naive CD4⁺ CD45RA⁺ %	NA	24.5	53–86	NA	46–77	39	40	33–66
Memory CD4⁺ CD45RO⁺ %	NA	24.5	9–26	NA	13–30	29.5	35	18–38
T reg CD4⁺ CD25⁺CD127^LOW %	NA	4.6	4.2–12.5	NA	4.2–12.5	NA	NA	4.2–10.5
CD8⁺ (/μl)	454	378	490–1,300	490	370–1,100	297	221	330–920
Naive CD8⁺ CCR7⁺CD45RA⁺ %	NA	69.7	52–68	NA	40–75	51	48	52–68
Central memory CD8⁺ CCR7⁺CD45RA⁻ %	NA	1	12–30	NA	13–37	4	5	10–31
Effector memory CD8⁺CCR7⁻CD45RA⁻ %	NA	10.6	1.5–13	NA	1.5–15	29	28	2.3–15
Terminal effector CD8⁺CCR7⁻CD45RA⁺ %	NA	39.6	1.7–24	NA	2–21	16	19	5–31
Natural killer cells
CD3⁻CD56⁺ (/μl)	114	91	130–720	120	100–480	NA	NA	70–480
B lymphocytes
CD19⁺ (/μl)	397	161	273–860	350	219–509	226	163	193–628
Naive B cells CD27⁻IgD⁺ %	NA	75	59.7–88.4	NA	58.5–84.6	89	79	61.6–87.4
Memory B cells CD27⁺ %	NA	NA	8.1–33.3	NA	9–35	7	18	14.6–26.6
Unswitched memory CD27⁺IgD⁺ %	NA	12	3.1–18	NA	3–21.1	4.4	12	2.6–13.4
Switched memory CD27⁺IgD⁻ %	NA	10	2.9–17.4	NA	4.4–20.5	3	6	4–21.2
Transitional CD24⁺⁺CD38⁺⁺ %	NA	12	5.4–9.2	NA	4.5–9.2	3	7	3.9–7.8
Plasmablast CD24⁻CD38⁺⁺ %	NA	0	0.8–2.7	NA	0.7–3.5	0.6	0.4	0.3–1.7
CD19⁺ CD21⁻CD38⁻ %	NA	2	1.8–5.2	NA	0.9–3.5	2	3	0.9–3.3

Summary of immunophenotyping results from the hospital laboratory. NA, not available. Values above or below reference (Ref.) ranges are marked in bold.

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