Retrospectively analyzed DBSs of patients with AT
| Number of analyzed AT DBS cards . | TREC levels abnormal (below assay’s cutoff value [provided]) . | Other notable (clinical) findings . | Reference . |
|---|---|---|---|
| 4 | 4/4 (15 copies per µl) | 4/4 decreased IgG2 and IgA 3/4 recurrent pulmonary infections | (35) |
| 9 | 9/9 (11 copies per 3.2 mm punch) | 3/9 urgent abnormal value (1 TREC copy per 3.2 mm punch) | (36) |
| 13 | 7/13 (25 copies per µL) | Lower CD4 T cells in patients with AT with reduced TRECs (R = 0.64) | (14) |
| 5 | 4/5 low TRECs (NA) | NA | (25) |
| 31 | 24/31 (77.4%) below respective assay’s TREC cutoff value | Totals | |
| Number of analyzed AT DBS cards . | TREC levels abnormal (below assay’s cutoff value [provided]) . | Other notable (clinical) findings . | Reference . |
|---|---|---|---|
| 4 | 4/4 (15 copies per µl) | 4/4 decreased IgG2 and IgA 3/4 recurrent pulmonary infections | (35) |
| 9 | 9/9 (11 copies per 3.2 mm punch) | 3/9 urgent abnormal value (1 TREC copy per 3.2 mm punch) | (36) |
| 13 | 7/13 (25 copies per µL) | Lower CD4 T cells in patients with AT with reduced TRECs (R = 0.64) | (14) |
| 5 | 4/5 low TRECs (NA) | NA | (25) |
| 31 | 24/31 (77.4%) below respective assay’s TREC cutoff value | Totals | |
Urgent abnormal value indicates absent or very low TRECs without DNA amplification failure.