Several examples of different classes of LD-resident proteins
| Examples of different types of LD-associated proteins . | ||
|---|---|---|
| Protein . | Notes . | References . |
| ERTOLD (ERTOLD targeting, previously class I) | ||
| GPAT4 | The LD marker tool LiveDrop is derived from an LD-targeting motif of GPAT4 | Wang et al., 2016 |
| ACSL3 | Localizes early to nascent LDs | Kassan et al., 2013 |
| PLIN1 | Highly abundant LD coat protein in adipocytes, and one of the first discovered LD proteins | Greenberg et al., 1991, Majchrzak et al., 2024 |
| CYTOLD (CYTOLD targeting, previously class II) | ||
| CTP:phosphocholine cytidylyltransferase (CCT) | Relocalizes from cytoplasm to LD surface to support phosphatidylcholine biosynthesis during LD growth | Krahmer et al., 2011 |
| Max-like protein X (MLX) | Transcription factor, activates glycolytic genes | Mejhert et al., 2020 |
| INTOLD | ||
| CGI-58 | Recruited to LDs via perilipin binding to regulate ATGL lipolysis | Yamaguchi et al., 2004 |
| VCP/p97 | Can be recruited to the LD surface by UBXD8 to regulate lipolysis | Olzmann et al., 2013 |
| TERTOLD | ||
| FATP1 | ER-associated protein that can bind to LDs | Xu et al., 2012 |
| Seipin | Promotes the maturation of nascent LDs to mature LDs | Several including Salo et al. (2016) and Wang et al. (2016) |
| SNX14 | Potential lipid transporter that associates with LDs following oleic acid–stimulated LD growth | Datta et al., 2019 |
| Ice2 | ER protein that regulates LD growth | Markgraf et al., 2014 |
| Examples of different types of LD-associated proteins . | ||
|---|---|---|
| Protein . | Notes . | References . |
| ERTOLD (ERTOLD targeting, previously class I) | ||
| GPAT4 | The LD marker tool LiveDrop is derived from an LD-targeting motif of GPAT4 | Wang et al., 2016 |
| ACSL3 | Localizes early to nascent LDs | Kassan et al., 2013 |
| PLIN1 | Highly abundant LD coat protein in adipocytes, and one of the first discovered LD proteins | Greenberg et al., 1991, Majchrzak et al., 2024 |
| CYTOLD (CYTOLD targeting, previously class II) | ||
| CTP:phosphocholine cytidylyltransferase (CCT) | Relocalizes from cytoplasm to LD surface to support phosphatidylcholine biosynthesis during LD growth | Krahmer et al., 2011 |
| Max-like protein X (MLX) | Transcription factor, activates glycolytic genes | Mejhert et al., 2020 |
| INTOLD | ||
| CGI-58 | Recruited to LDs via perilipin binding to regulate ATGL lipolysis | Yamaguchi et al., 2004 |
| VCP/p97 | Can be recruited to the LD surface by UBXD8 to regulate lipolysis | Olzmann et al., 2013 |
| TERTOLD | ||
| FATP1 | ER-associated protein that can bind to LDs | Xu et al., 2012 |
| Seipin | Promotes the maturation of nascent LDs to mature LDs | Several including Salo et al. (2016) and Wang et al. (2016) |
| SNX14 | Potential lipid transporter that associates with LDs following oleic acid–stimulated LD growth | Datta et al., 2019 |
| Ice2 | ER protein that regulates LD growth | Markgraf et al., 2014 |