Table 1. Immunophenotyping of index... | Rockefeller University Press

Table 1.

Immunophenotyping of index patient lymphocytes at age 11 years

Hematologic and immunologic parameters	Index patient	Age-matched reference range
T cell studies (units)
CD3⁺ (10⁹ cells/liter)	0.374↓	0.850–3.200
CD3⁺CD4⁺ (10⁹ cells/liter)	0.151↓	0.400–2.100
CD3⁺CD8⁺ (10⁹ cells/liter)	0.208↓	0.300–1.300
CD3⁺CD4⁺CD45RA⁺CD31⁺ (recent thymic emigrants) (%)	2↓	31–81
CD4⁺ T cell repertoire	Normal polyclonal pattern
CD8⁺ T cell repertoire
CD3⁺CD8⁺ TCR Vβ12 (% of total CD8⁺ cells)	39.5↑	0.33–3.33
CD3⁺CD8⁺ TCR Vβ14 (% of total CD8⁺ cells)	18.35↑	1.50–14.30
B cell studies (units)
CD19⁺ (10⁹ cells/liter)	0.069↓	0.120–0.740
CD19⁺CD27⁺ memory (%)	1.3↓	13.3–47.9
CD19⁺CD27⁻IgD⁺ naïve (%)	86.1↑	57.3–82.5
CD19⁺CD27⁺IgM⁺IgD⁺CD38^dimCD24⁺ (memory, non-switched) (%)	0.8↓	4.6–18.2
CD19⁺CD27⁺IgM⁻IgD⁻CD38^dimCD24⁻ (memory, class-switched) (%)	0.5↓	8.7–25.6
CD19⁺IgM⁺CD38⁺⁺ (transitional) (%)	0.2↓	1.4–13.0
CD19⁺CD21^loCD38^lo (%)	65↑	1.0–11.0

Hematologic and immunologic parameters	Index patient	Age-matched reference range
T cell studies (units)
CD3⁺ (10⁹ cells/liter)	0.374↓	0.850–3.200
CD3⁺CD4⁺ (10⁹ cells/liter)	0.151↓	0.400–2.100
CD3⁺CD8⁺ (10⁹ cells/liter)	0.208↓	0.300–1.300
CD3⁺CD4⁺CD45RA⁺CD31⁺ (recent thymic emigrants) (%)	2↓	31–81
CD4⁺ T cell repertoire	Normal polyclonal pattern
CD8⁺ T cell repertoire
CD3⁺CD8⁺ TCR Vβ12 (% of total CD8⁺ cells)	39.5↑	0.33–3.33
CD3⁺CD8⁺ TCR Vβ14 (% of total CD8⁺ cells)	18.35↑	1.50–14.30
B cell studies (units)
CD19⁺ (10⁹ cells/liter)	0.069↓	0.120–0.740
CD19⁺CD27⁺ memory (%)	1.3↓	13.3–47.9
CD19⁺CD27⁻IgD⁺ naïve (%)	86.1↑	57.3–82.5
CD19⁺CD27⁺IgM⁺IgD⁺CD38^dimCD24⁺ (memory, non-switched) (%)	0.8↓	4.6–18.2
CD19⁺CD27⁺IgM⁻IgD⁻CD38^dimCD24⁻ (memory, class-switched) (%)	0.5↓	8.7–25.6
CD19⁺IgM⁺CD38⁺⁺ (transitional) (%)	0.2↓	1.4–13.0
CD19⁺CD21^loCD38^lo (%)	65↑	1.0–11.0

Bold denotes high values (above the reference range), and italics denotes low values (below the reference range).