Summary of anti-NANP6 mAbs used in this study
| mAb . | CDR-H3 . | VH gene . | CDR-K3/L3 . | VK/A gene . | IgG (%) . | VH SHM (%) . | EC50 (nM) . | Sterile protection (%) . | ISI (%) . | IFA (WT Pf) . | IFA (Tg Pb) . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MA1 | ARPPPTIVGDTNNWYFGL | IGHV3-33 | QSYDSSLSG | IGLV1-40 | 13 | 1.6 | 91 | 33.3 | 35 | 114 | 60 |
| MA5 | ARSTVEYAPGRSVWTLED | IGHV1-69 | MQALQSPT | IGKV2-28 | 0.4 | 12.6 | - | 0 | - | - | - |
| MA6 | ARDGGHSTSWSNAFDI | IGHV3-33 | QQYNSYWT | IGKV1-5 | 0.6 | 1.7 | 1.2 | 92 | 94 | 119 | 45 |
| MA8 | AKNAPCSGSMSCYTFDY | IGHV3-30 | QQYIRYPPT | IGKV1-16 | 19.6 | 8.2 | 3.1 | - | 52 | 129 | 54 |
| 580 | AKPGGDSSPAGRTWFDP | IGHV3-23 | QQYYSSPIT | IGKV4-1 | - | 12.2 | 100 | 50 | 87 | 155 | 108 |
| 663 | TTLLIYESDVGVDF | IGHV3-23 | VQTVQVPYT | IGKV2-40 | - | 16.7 | 8.3 | 100 | 98 | 98 | 98 |
| mAb . | CDR-H3 . | VH gene . | CDR-K3/L3 . | VK/A gene . | IgG (%) . | VH SHM (%) . | EC50 (nM) . | Sterile protection (%) . | ISI (%) . | IFA (WT Pf) . | IFA (Tg Pb) . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MA1 | ARPPPTIVGDTNNWYFGL | IGHV3-33 | QSYDSSLSG | IGLV1-40 | 13 | 1.6 | 91 | 33.3 | 35 | 114 | 60 |
| MA5 | ARSTVEYAPGRSVWTLED | IGHV1-69 | MQALQSPT | IGKV2-28 | 0.4 | 12.6 | - | 0 | - | - | - |
| MA6 | ARDGGHSTSWSNAFDI | IGHV3-33 | QQYNSYWT | IGKV1-5 | 0.6 | 1.7 | 1.2 | 92 | 94 | 119 | 45 |
| MA8 | AKNAPCSGSMSCYTFDY | IGHV3-30 | QQYIRYPPT | IGKV1-16 | 19.6 | 8.2 | 3.1 | - | 52 | 129 | 54 |
| 580 | AKPGGDSSPAGRTWFDP | IGHV3-23 | QQYYSSPIT | IGKV4-1 | - | 12.2 | 100 | 50 | 87 | 155 | 108 |
| 663 | TTLLIYESDVGVDF | IGHV3-23 | VQTVQVPYT | IGKV2-40 | - | 16.7 | 8.3 | 100 | 98 | 98 | 98 |
MA1, MA5, MA6, and MA8 were isolated from four different VAC065 volunteers. Control mAbs 580 and 663 were previously reported by Triller et al. (2017). IgG (%): the percent relative abundance of the clone’s lineage in the total IgG anti-NANP6 repertoire.