Multifunctional LIR motif sequences are shown, with the core LIR (underlined), non-Atg8 motifs (bold), and overlapping motifs (underlined and bold) indicated. Only the core LIR residues are marked, although flanking residues often contribute critically to LIR function. Motifs are categorized by how each non-Atg8 motif is integrated with its corresponding LIR—adjacent, bipartite, and hybrid—in order of increasing overlap.