The clinical and microbiological profile of 18 patients with chronic granulomatous disease who died secondary to invasive aspergillosis
| . | Patient code (P) . | Affected organs . | Aspergillus detection . | Treatment . | Co-infections . | Age of death . |
|---|---|---|---|---|---|---|
| 1 | P1 | Lung | Galactomannan antigen | Voriconazole | Achromobacter xylosoxidans and N. subflava | 16 yo 9 mo |
| 2 | P8 | Lung | Galactomannan antigen | Voriconazole and caspofungin | | 1 yo 10 mo |
| 3 | P9 | Lung | A. niger | Voriconazole, caspofungin, and amphotericin B | Salmonella spp, P. aeruginosa, C. freundii, K. variicola, and M. chimaera | 16 yo 9 mo |
| A. terreus | ||||||
| 4 | P11 | Lung, skin, and CNS | Galactomannan antigen | Voriconazole, caspofungin, and amphotericin B | None | 15 yo 4 mo |
| 5 | P13 | Lung | A. fumigatus | Voriconazole | P. jirovecii | 4 yo |
| 6 | P16 | Lung | Clinical and radiological findings | Voriconazole | None | 11 yo 11 mo |
| 7 | P17 | Lung | A. terreus | Voriconazole and caspofungin | A. israelii and S. aureus | 5 yo 5 mo |
| A. flavus | ||||||
| 8 | P18 | Lung and CNS | A. fumigatus | Voriconazole, caspofungin, amphotericin B, and posaconazole | Salmonella spp. | 7 yo 11 mo |
| 9 | P19 | Lung | Galactomannan antigen | Voriconazole and caspofungin | None | 1 yo 1 mo |
| 10 | P25 | Lung | Clinical and radiological findings | Voriconazole, caspofungin, and amphotericin B | S. haemolyticus and S. maltophilia | 6 yo 8 mo |
| 11 | P27 | Lung, skin, and CNS | Aspergillus spp. | Voriconazole, caspofungin, amphotericin B, and posaconazole | None | 4 yo |
| 12 | P31 | Lung | A. fumigatus | Voriconazole | None | 12 mo |
| 13 | P32 | Lung | Aspergillus spp. | None | B. cepacia | 10 mo |
| 14 | P33 | Lung | A. fumigatus | Fluconazole | M. tuberculosis and K. pneumoniae | 2 yo 11 mo |
| 15 | P41 | Lung | A. nidulans | Voriconazole, caspofungin, and amphotericin B | B. cepacia, Penicilium spp., and Pseudomonas spp. | 12 yo 11 mo |
| 16 | P42 | Lung and bone | A. fumigatus and A. versicolor | Voriconazole | A. lwoffi and P. aeruginosa | 16 yo 16 mo |
| 17 | P43 | Lung and pericardium | A. versicolor | Voriconazole, caspofungin, amphotericin B, and posaconazole | S. aureus and S. hominis | 10 yo 1 mo |
| 18 | P44 | Lung and bone | Aspergillus spp. | Voriconazole, caspofungin, and amphotericin B | S. mitis, K. pneumoniae, P. aeruginosa, S. hominis, and C. albicans | 6 yo 9 mo |
| . | Patient code (P) . | Affected organs . | Aspergillus detection . | Treatment . | Co-infections . | Age of death . |
|---|---|---|---|---|---|---|
| 1 | P1 | Lung | Galactomannan antigen | Voriconazole | Achromobacter xylosoxidans and N. subflava | 16 yo 9 mo |
| 2 | P8 | Lung | Galactomannan antigen | Voriconazole and caspofungin | | 1 yo 10 mo |
| 3 | P9 | Lung | A. niger | Voriconazole, caspofungin, and amphotericin B | Salmonella spp, P. aeruginosa, C. freundii, K. variicola, and M. chimaera | 16 yo 9 mo |
| A. terreus | ||||||
| 4 | P11 | Lung, skin, and CNS | Galactomannan antigen | Voriconazole, caspofungin, and amphotericin B | None | 15 yo 4 mo |
| 5 | P13 | Lung | A. fumigatus | Voriconazole | P. jirovecii | 4 yo |
| 6 | P16 | Lung | Clinical and radiological findings | Voriconazole | None | 11 yo 11 mo |
| 7 | P17 | Lung | A. terreus | Voriconazole and caspofungin | A. israelii and S. aureus | 5 yo 5 mo |
| A. flavus | ||||||
| 8 | P18 | Lung and CNS | A. fumigatus | Voriconazole, caspofungin, amphotericin B, and posaconazole | Salmonella spp. | 7 yo 11 mo |
| 9 | P19 | Lung | Galactomannan antigen | Voriconazole and caspofungin | None | 1 yo 1 mo |
| 10 | P25 | Lung | Clinical and radiological findings | Voriconazole, caspofungin, and amphotericin B | S. haemolyticus and S. maltophilia | 6 yo 8 mo |
| 11 | P27 | Lung, skin, and CNS | Aspergillus spp. | Voriconazole, caspofungin, amphotericin B, and posaconazole | None | 4 yo |
| 12 | P31 | Lung | A. fumigatus | Voriconazole | None | 12 mo |
| 13 | P32 | Lung | Aspergillus spp. | None | B. cepacia | 10 mo |
| 14 | P33 | Lung | A. fumigatus | Fluconazole | M. tuberculosis and K. pneumoniae | 2 yo 11 mo |
| 15 | P41 | Lung | A. nidulans | Voriconazole, caspofungin, and amphotericin B | B. cepacia, Penicilium spp., and Pseudomonas spp. | 12 yo 11 mo |
| 16 | P42 | Lung and bone | A. fumigatus and A. versicolor | Voriconazole | A. lwoffi and P. aeruginosa | 16 yo 16 mo |
| 17 | P43 | Lung and pericardium | A. versicolor | Voriconazole, caspofungin, amphotericin B, and posaconazole | S. aureus and S. hominis | 10 yo 1 mo |
| 18 | P44 | Lung and bone | Aspergillus spp. | Voriconazole, caspofungin, and amphotericin B | S. mitis, K. pneumoniae, P. aeruginosa, S. hominis, and C. albicans | 6 yo 9 mo |
yo, years old.