Table 1. Molecular and clinical features... | Rockefeller University Press

Table 1.

Molecular and clinical features of 45 patients with chronic granulomatous disease and invasive aspergillosis in Mexico

Patient code (P)	Sex	Gene	Events	IA Classification (EORTC/MSGERC)	Aspergillus species	Treatment	Time of Treatment		Steroids	Parallel antituberculosis therapy to antifungal therapy	Organs involved	Co-infection to aspergillosis	Clinical course	Cause of death
Patient code (P)	Sex	Gene	Events	IA Classification (EORTC/MSGERC)	Aspergillus species	Treatment	<175 days	>75 days	Steroids	Parallel antituberculosis therapy to antifungal therapy	Organs involved	Co-infection to aspergillosis	Clinical course	Cause of death
P1⁽⁴⁾	M	CYBB	2	Possible		Voriconazole	*		●		Lung	Enterococcus faecalis, Achromobacter xylosoxidans, and Neisseria subflava	Dead	IA
P1⁽⁴⁾	M	CYBB	2	Probable		Voriconazole		*	●		Lung		Dead	IA
P2⁽⁴⁾	M	CYBB	1	Probable		Voriconazole and caspofungin		*	●		Lung	Pseudomonas aeruginosa	Alive
P3⁽⁴⁾	M	CYBB	4	Possible		Voriconazole, caspofungin, and amphotericin B	*		●	R, H, Z, and E	Lung, liver, spleen, and kidney	Serratia marcescens	Dead	Cardiogenic shock
				Possible		Voriconazole		*			Lung and bone
				Possible		Voriconazole and caspofungin		*			Lung and bone
				Possible		Voriconazole and fluconazole	*		●		Lung
P4⁽⁴⁾	M	NCF2	1	Possible		Voriconazole and caspofungin	*		●		Lung		Dead	Septic shock
P5⁽⁴⁾	M	CYBB	4	Possible		Voriconazole		*	●	R, H, Z, and E	Lung	Exophiala dermatitidis	Alive
				Possible		Voriconazole		*	●		Lung
				Probable		Voriconazole and amphotericin B	*		●		Lung
				Probable		Voriconazole		*	●		Lung
P6⁽⁴⁾	M	CYBB	2	Possible		Voriconazole and caspofungin		*		R, H, Z, E, and LVX	Lung		Alive
P6⁽⁴⁾	M	CYBB	2	Possible		Voriconazole	*				Lung		Alive
P7⁽⁴⁾^a	F	NCF2	2	Possible		Voriconazole and posaconazole		*			Lung and spleen		Alive
P7⁽⁴⁾^a	F	NCF2	2	Probable	A. fumigatus	Voriconazole		*		H, E, CLR, and LVX	Lung		Alive
P8	M	CYBB	1	Probable		Voriconazole and caspofungin	*		●	H, R, E, CIP, and CLR	Lung		Dead	IA
P9⁽⁴⁾	F	CYBA	3	Probable	Aspergillus spp	Voriconazole		*			Lung	Salmonella spp., P. aeruginosa, Citrobacter freundii, Klebsiella variicola, and Mycobacterium chimaera	Dead	IA
				Probable		Voriconazole		*	●		Lung
				Probable	A. niger A. terreus	Voriconazole, caspofungin, and amphotericin B		*	●	R, Z, E, and H	Lung
P10	M	CYBB	1	Possible		Voriconazole, caspofungin, and posaconazole		*	●	LVX, H, Z, and E	Lung		Dead	Septic shock
P11⁽⁴⁾	M	NCF2	1	Probable		Voriconazole, caspofungin, and amphotericin B	*		●	H, R, and E	Lung, skin, and CNS		Dead	IA
P12⁽⁴⁾	M	CYBB	1	Proven	A. versicolor	Voriconazole		*	●		Lung, liver, spleen, and CNS	S. marcescens and Burkholderia cepacia	Alive
P13⁽⁴⁾	M	CYBB	2	Probable		Voriconazole, caspofungin, and amphotericin B		*	●		Lung and spleen	Pneumocystis jirovecii	Dead	IA
P13⁽⁴⁾	M	CYBB	2	Probable	A. fumigatus	Voriconazole	*				Lung	Pneumocystis jirovecii	Dead	IA
P14⁽⁴⁾	F	NCF2	4	Possible		Voriconazole		*	●	CLR, R, H, and E	Lung	E. coli BLEE, Klebsiella pneumoniae BLEE, P. aeruginosa, Pseudomonas rhodesiae, Streptococcus oralis, Streptococcus salivarius, Penicillium spp., and Campylobacter spp.	Alive
				Possible		Voriconazole, caspofungin, and amphotericin B		*	●		Lung, liver, and spleen
				Proven	A. ustus	Voriconazole	*			CLR, R, H, and E	Lung
				Probable		Voriconazole		*	●		Lung
P15⁽⁴⁾	M	CYBB	1	Probable		Voriconazole		*	●		Lung		Alive
P16	M	CYBB	1	Possible		Voriconazole		*			Lung		Dead	IA
P17^b	M	CYBB	1	Probable	A. terreus	Voriconazole and caspofungin	*		●		Lung	Actinomyces israelii and Staphylococcus aureus	Dead	IA
P17^b	M	CYBB	1	Probable	A. flavus	Voriconazole and caspofungin	*		●		Lung	Actinomyces israelii and Staphylococcus aureus	Dead
P18⁽⁴⁾	M	CYBB	2	Possible		Voriconazole	*				Lung	Salmonella spp.	Dead	IA
P18⁽⁴⁾	M	CYBB	2	Probable	A. fumigatus	Voriconazole, caspofungin, amphotericin B, and posaconazole		*	●		Lung and CNS	Salmonella spp.	Dead	IA
P19⁽⁴⁾	M	CYBB	1	Probable		Voriconazole and caspofungin	*		●		Lung		Dead	IA
P20⁽⁴⁾	M	CYBA	3	Possible		Voriconazole	*				Lung	S. marcescens, Burkholderia multivorans, P. aeruginosa, and K. pneumoniae BLEE	Dead	Pneumonia K. pneumoniae
				Possible		Voriconazole		*			Lung and spleen
				Proven	A. flavus	Voriconazole, caspofungin, and amphotericin B		*	●		Lung and CNS
P21⁽⁴⁾	F	NCF2	2	Possible		Voriconazole and caspofungin		*	●		Lung	Salmonella spp., Streptococcus pneumoniae, P. aureginosa, and Hormographiella aspergillata	Alive
P21⁽⁴⁾	F	NCF2	2	Probable		Voriconazole	*		●		Lung		Alive
P22⁽⁴⁾	M	NCF1	3	Possible		Voriconazole	*		●		Lung	K. pneumoniae and Enterobacter cloacae	Alive
				Possible		Voriconazole		*		H, E, LZD, and LVX	Lung
				Probable		Voriconazole, caspofungin, and amphotericin B		*		H, E	Lung and CNS
P23⁽⁴⁾	M	CYBB	1	Probable		Voriconazole and caspofungin		*	●		Lung	E. coli	Dead	Septic shock
P24	M	CYBB	1	Probable	Aspergillus spp	Voriconazole	*		●		Lung	Staphylococcushominis	Alive
P25⁽⁴⁾	M	CYBB	1	Possible		Voriconazole, caspofungin, and amphotericin B		*	●		Lung	Staphylococcus haemolyticus and Stenotrophomonas maltophilia	Dead	IA
P26⁽⁴⁾	M	NCF1	3	Possible		Voriconazole	*				Lung	Candida guilliermondii	Alive
				Proven	A. fumigatus	Voriconazole		*	●		Lung
				Proven	A. nidulans A. fumigatus A. versicolor	Voriconazole and amphotericin B		*	●		Lung
P27⁽²⁴⁾	M	CYBB	1	Probable	Aspergillus spp	Voriconazole, caspofungin, amphotericin B, and posaconazole		*	●	H, E, and LVX	Lung, skin, and CNS		Dead	IA
P28	M	CYBB	1	Probable		Voriconazole, caspofungin, and amphotericin		*	●	H, R, Z, and E	Lung		Alive
P29⁽⁴⁾	M	CYBB	3	Possible		Voriconazole	*				Lung		Alive
				Possible		Voriconazole		*			Lung
				Possible		Voriconazole		*	●		Lung
P30⁽⁴⁾	M	CYBB	1	Possible		Voriconazole and caspofungin		*	●		Lung		Alive
P31⁽¹⁶⁾^c	M	CYBB	2	Probable	Aspergillus spp	Voriconazole	*				Lung, bone, and skin	E. faecalis	Dead	IA
P31⁽¹⁶⁾^c	M	CYBB	2	Probable	A. fumigatus	Voriconazole	*				Lung	E. faecalis	Dead	IA
P32⁽⁴⁾	M	CYBB	1	Proven	Aspergillus spp	None			●		Lung	B. cepacia	Dead	IA
P33	M	CYBB	1	Proven	A. fumigatus	Fluconazole		*	●		Lung	Mycobacterium tuberculosis and K. pneumoniae	Dead	IA
P34⁽⁴⁾	F	CYBB	1	Probable		Voriconazole and amphotericin B	*		●		Lung		Alive
P35⁽⁴⁾	M	CYBB	1	Proven	A. versicolor	Voriconazole		*	●	H, R, Z, and E	Lung		Alive
P36⁽⁴⁾	M	CYBB	2	Possible		Voriconazole		*	●		Lung and liver		Alive
P36⁽⁴⁾	M	CYBB	2	Probable	A. fumigatus	Voriconazole		*	●		Lung and skin		Alive
P37⁽⁴⁾	M	NCF2	4	Possible		Voriconazole, caspofungin, and amphotericin B		*			Lung	S. marcescens	Alive
				Probable		Voriconazole and caspofungin		*		R, H, Z, and E	Lung
				Proven	A. versicolor	Voriconazole		*	●		Lung
				Proven	A. fumigatus	Voriconazole		*	●		Lung and skin
P38⁽⁴⁾	F	CYBA	1	Probable	A. fumigatus	Voriconazole	*				Lung		Dead	Accident
P39	M	CYBB	2	Possible		Voriconazole		*			Lung	Pseudomonas putida and K. pneumoniae BLEE	Alive
P39	M	CYBB	2	Probable	A. versicolor	Voriconazole		*			Lung	Pseudomonas putida and K. pneumoniae BLEE	Alive
P40	M	CYBB	1	Probable		Amphotericin B	*		●		Lung	S. aureus and S. maltophilia	Dead	Septic shock
P41	M	CYBB	1	Proven	A. nidulans	Voriconazole, caspofungin, and amphotericin B	*		●		Lung	B. cepacia, Penicillium spp., and Pseudomonas spp.	Dead	IA
P42	M	CYBB	1	Probable	A. fumigatus A. versicolor	Voriconazole	*				Lung and bone	A. lwoffi and P. aeruginosa	Dead	IA
P43	M	CYBB	1	Proven	A. versicolor	Voriconazole, caspofungin, amphotericin B, and posaconazole		*	●		Lung and pericardium	S. aureus and S. hominis	Dead	IA
P44	M	CYBB	1	Proven	Aspergillus spp	Voriconazole, caspofungin, and amphotericin B		*	●		Lung and bone	Streptococcus mitis, K. pneumoniae, P. aeruginosa, S. hominis, and Candida albicans	Dead	IA
P45⁽⁴⁾	M	NCF1	4	Possible		Voriconazole, itraconazole, and anidulafungin	*				Lung		Dead	Cerebral cryptococcosis
				Probable	A. fumigatus A. flavus	Itraconazole		*	●		Lung
				Probable	A. fumigatus	Voriconazole, amphotericin B, itraconazole, fluconazole, and anidulafungin	*				Lung
				Probable	A. flavus	Voriconazole, caspofungin, and amphotericin B	*		●		Lung

Patient code (P)	Sex	Gene	Events	IA Classification (EORTC/MSGERC)	Aspergillus species	Treatment	Time of Treatment		Steroids	Parallel antituberculosis therapy to antifungal therapy	Organs involved	Co-infection to aspergillosis	Clinical course	Cause of death
Patient code (P)	Sex	Gene	Events	IA Classification (EORTC/MSGERC)	Aspergillus species	Treatment	<175 days	>75 days	Steroids	Parallel antituberculosis therapy to antifungal therapy	Organs involved	Co-infection to aspergillosis	Clinical course	Cause of death
P1⁽⁴⁾	M	CYBB	2	Possible		Voriconazole	*		●		Lung	Enterococcus faecalis, Achromobacter xylosoxidans, and Neisseria subflava	Dead	IA
P1⁽⁴⁾	M	CYBB	2	Probable		Voriconazole		*	●		Lung		Dead	IA
P2⁽⁴⁾	M	CYBB	1	Probable		Voriconazole and caspofungin		*	●		Lung	Pseudomonas aeruginosa	Alive
P3⁽⁴⁾	M	CYBB	4	Possible		Voriconazole, caspofungin, and amphotericin B	*		●	R, H, Z, and E	Lung, liver, spleen, and kidney	Serratia marcescens	Dead	Cardiogenic shock
				Possible		Voriconazole		*			Lung and bone
				Possible		Voriconazole and caspofungin		*			Lung and bone
				Possible		Voriconazole and fluconazole	*		●		Lung
P4⁽⁴⁾	M	NCF2	1	Possible		Voriconazole and caspofungin	*		●		Lung		Dead	Septic shock
P5⁽⁴⁾	M	CYBB	4	Possible		Voriconazole		*	●	R, H, Z, and E	Lung	Exophiala dermatitidis	Alive
				Possible		Voriconazole		*	●		Lung
				Probable		Voriconazole and amphotericin B	*		●		Lung
				Probable		Voriconazole		*	●		Lung
P6⁽⁴⁾	M	CYBB	2	Possible		Voriconazole and caspofungin		*		R, H, Z, E, and LVX	Lung		Alive
P6⁽⁴⁾	M	CYBB	2	Possible		Voriconazole	*				Lung		Alive
P7⁽⁴⁾^a	F	NCF2	2	Possible		Voriconazole and posaconazole		*			Lung and spleen		Alive
P7⁽⁴⁾^a	F	NCF2	2	Probable	A. fumigatus	Voriconazole		*		H, E, CLR, and LVX	Lung		Alive
P8	M	CYBB	1	Probable		Voriconazole and caspofungin	*		●	H, R, E, CIP, and CLR	Lung		Dead	IA
P9⁽⁴⁾	F	CYBA	3	Probable	Aspergillus spp	Voriconazole		*			Lung	Salmonella spp., P. aeruginosa, Citrobacter freundii, Klebsiella variicola, and Mycobacterium chimaera	Dead	IA
				Probable		Voriconazole		*	●		Lung
				Probable	A. niger A. terreus	Voriconazole, caspofungin, and amphotericin B		*	●	R, Z, E, and H	Lung
P10	M	CYBB	1	Possible		Voriconazole, caspofungin, and posaconazole		*	●	LVX, H, Z, and E	Lung		Dead	Septic shock
P11⁽⁴⁾	M	NCF2	1	Probable		Voriconazole, caspofungin, and amphotericin B	*		●	H, R, and E	Lung, skin, and CNS		Dead	IA
P12⁽⁴⁾	M	CYBB	1	Proven	A. versicolor	Voriconazole		*	●		Lung, liver, spleen, and CNS	S. marcescens and Burkholderia cepacia	Alive
P13⁽⁴⁾	M	CYBB	2	Probable		Voriconazole, caspofungin, and amphotericin B		*	●		Lung and spleen	Pneumocystis jirovecii	Dead	IA
P13⁽⁴⁾	M	CYBB	2	Probable	A. fumigatus	Voriconazole	*				Lung	Pneumocystis jirovecii	Dead	IA
P14⁽⁴⁾	F	NCF2	4	Possible		Voriconazole		*	●	CLR, R, H, and E	Lung	E. coli BLEE, Klebsiella pneumoniae BLEE, P. aeruginosa, Pseudomonas rhodesiae, Streptococcus oralis, Streptococcus salivarius, Penicillium spp., and Campylobacter spp.	Alive
				Possible		Voriconazole, caspofungin, and amphotericin B		*	●		Lung, liver, and spleen
				Proven	A. ustus	Voriconazole	*			CLR, R, H, and E	Lung
				Probable		Voriconazole		*	●		Lung
P15⁽⁴⁾	M	CYBB	1	Probable		Voriconazole		*	●		Lung		Alive
P16	M	CYBB	1	Possible		Voriconazole		*			Lung		Dead	IA
P17^b	M	CYBB	1	Probable	A. terreus	Voriconazole and caspofungin	*		●		Lung	Actinomyces israelii and Staphylococcus aureus	Dead	IA
P17^b	M	CYBB	1	Probable	A. flavus	Voriconazole and caspofungin	*		●		Lung	Actinomyces israelii and Staphylococcus aureus	Dead
P18⁽⁴⁾	M	CYBB	2	Possible		Voriconazole	*				Lung	Salmonella spp.	Dead	IA
P18⁽⁴⁾	M	CYBB	2	Probable	A. fumigatus	Voriconazole, caspofungin, amphotericin B, and posaconazole		*	●		Lung and CNS	Salmonella spp.	Dead	IA
P19⁽⁴⁾	M	CYBB	1	Probable		Voriconazole and caspofungin	*		●		Lung		Dead	IA
P20⁽⁴⁾	M	CYBA	3	Possible		Voriconazole	*				Lung	S. marcescens, Burkholderia multivorans, P. aeruginosa, and K. pneumoniae BLEE	Dead	Pneumonia K. pneumoniae
				Possible		Voriconazole		*			Lung and spleen
				Proven	A. flavus	Voriconazole, caspofungin, and amphotericin B		*	●		Lung and CNS
P21⁽⁴⁾	F	NCF2	2	Possible		Voriconazole and caspofungin		*	●		Lung	Salmonella spp., Streptococcus pneumoniae, P. aureginosa, and Hormographiella aspergillata	Alive
P21⁽⁴⁾	F	NCF2	2	Probable		Voriconazole	*		●		Lung		Alive
P22⁽⁴⁾	M	NCF1	3	Possible		Voriconazole	*		●		Lung	K. pneumoniae and Enterobacter cloacae	Alive
				Possible		Voriconazole		*		H, E, LZD, and LVX	Lung
				Probable		Voriconazole, caspofungin, and amphotericin B		*		H, E	Lung and CNS
P23⁽⁴⁾	M	CYBB	1	Probable		Voriconazole and caspofungin		*	●		Lung	E. coli	Dead	Septic shock
P24	M	CYBB	1	Probable	Aspergillus spp	Voriconazole	*		●		Lung	Staphylococcushominis	Alive
P25⁽⁴⁾	M	CYBB	1	Possible		Voriconazole, caspofungin, and amphotericin B		*	●		Lung	Staphylococcus haemolyticus and Stenotrophomonas maltophilia	Dead	IA
P26⁽⁴⁾	M	NCF1	3	Possible		Voriconazole	*				Lung	Candida guilliermondii	Alive
				Proven	A. fumigatus	Voriconazole		*	●		Lung
				Proven	A. nidulans A. fumigatus A. versicolor	Voriconazole and amphotericin B		*	●		Lung
P27⁽²⁴⁾	M	CYBB	1	Probable	Aspergillus spp	Voriconazole, caspofungin, amphotericin B, and posaconazole		*	●	H, E, and LVX	Lung, skin, and CNS		Dead	IA
P28	M	CYBB	1	Probable		Voriconazole, caspofungin, and amphotericin		*	●	H, R, Z, and E	Lung		Alive
P29⁽⁴⁾	M	CYBB	3	Possible		Voriconazole	*				Lung		Alive
				Possible		Voriconazole		*			Lung
				Possible		Voriconazole		*	●		Lung
P30⁽⁴⁾	M	CYBB	1	Possible		Voriconazole and caspofungin		*	●		Lung		Alive
P31⁽¹⁶⁾^c	M	CYBB	2	Probable	Aspergillus spp	Voriconazole	*				Lung, bone, and skin	E. faecalis	Dead	IA
P31⁽¹⁶⁾^c	M	CYBB	2	Probable	A. fumigatus	Voriconazole	*				Lung	E. faecalis	Dead	IA
P32⁽⁴⁾	M	CYBB	1	Proven	Aspergillus spp	None			●		Lung	B. cepacia	Dead	IA
P33	M	CYBB	1	Proven	A. fumigatus	Fluconazole		*	●		Lung	Mycobacterium tuberculosis and K. pneumoniae	Dead	IA
P34⁽⁴⁾	F	CYBB	1	Probable		Voriconazole and amphotericin B	*		●		Lung		Alive
P35⁽⁴⁾	M	CYBB	1	Proven	A. versicolor	Voriconazole		*	●	H, R, Z, and E	Lung		Alive
P36⁽⁴⁾	M	CYBB	2	Possible		Voriconazole		*	●		Lung and liver		Alive
P36⁽⁴⁾	M	CYBB	2	Probable	A. fumigatus	Voriconazole		*	●		Lung and skin		Alive
P37⁽⁴⁾	M	NCF2	4	Possible		Voriconazole, caspofungin, and amphotericin B		*			Lung	S. marcescens	Alive
				Probable		Voriconazole and caspofungin		*		R, H, Z, and E	Lung
				Proven	A. versicolor	Voriconazole		*	●		Lung
				Proven	A. fumigatus	Voriconazole		*	●		Lung and skin
P38⁽⁴⁾	F	CYBA	1	Probable	A. fumigatus	Voriconazole	*				Lung		Dead	Accident
P39	M	CYBB	2	Possible		Voriconazole		*			Lung	Pseudomonas putida and K. pneumoniae BLEE	Alive
P39	M	CYBB	2	Probable	A. versicolor	Voriconazole		*			Lung	Pseudomonas putida and K. pneumoniae BLEE	Alive
P40	M	CYBB	1	Probable		Amphotericin B	*		●		Lung	S. aureus and S. maltophilia	Dead	Septic shock
P41	M	CYBB	1	Proven	A. nidulans	Voriconazole, caspofungin, and amphotericin B	*		●		Lung	B. cepacia, Penicillium spp., and Pseudomonas spp.	Dead	IA
P42	M	CYBB	1	Probable	A. fumigatus A. versicolor	Voriconazole	*				Lung and bone	A. lwoffi and P. aeruginosa	Dead	IA
P43	M	CYBB	1	Proven	A. versicolor	Voriconazole, caspofungin, amphotericin B, and posaconazole		*	●		Lung and pericardium	S. aureus and S. hominis	Dead	IA
P44	M	CYBB	1	Proven	Aspergillus spp	Voriconazole, caspofungin, and amphotericin B		*	●		Lung and bone	Streptococcus mitis, K. pneumoniae, P. aeruginosa, S. hominis, and Candida albicans	Dead	IA
P45⁽⁴⁾	M	NCF1	4	Possible		Voriconazole, itraconazole, and anidulafungin	*				Lung		Dead	Cerebral cryptococcosis
				Probable	A. fumigatus A. flavus	Itraconazole		*	●		Lung
				Probable	A. fumigatus	Voriconazole, amphotericin B, itraconazole, fluconazole, and anidulafungin	*				Lung
				Probable	A. flavus	Voriconazole, caspofungin, and amphotericin B	*		●		Lung

M, Male; F, Female; H, isoniazid; R, rifampicin; E, ethambutol; Z, pyrazinamide; CLR, clarithromycin; LVX, levofloxacin; CIP, ciprofloxacin; LZD, linezolid. Superscript numbers in column one indicate bibliographic citations if patient previously published. * time of antifungal treatment; ● the patient received steroids.

The patient was exposed to mulch.

The patient visited a cave.

The patient lived in jail after birth.

View Large

This Feature Is Available To Subscribers Only