ALL risk loci identified by GWAS
| Region . | Nearest gene . | Effect size . | ALL (subtype) . | Reference . |
|---|---|---|---|---|
| 5q31.1 | C5orf56 | 1.29 | B-ALL (high-hyperdiploidy) | (97) |
| 6p21.31 | BAK1 | 1.3 | B-ALL (high-hyperdiploidy) | |
| 17q21.32 | IGF2BP1 | 1.33 | B-ALL (ETV6-RUNX1 positive) | |
| 9q21.3 | TLE1 | 1.52 | B-ALL | |
| 7p12.2 | IKZF1 | 1.69 | B-ALL | (98) |
| 10q21.2 | ARID5B | 1.65 | B-ALL (hyperdiploid) | |
| 14q11.2 | CEBPE | 1.34 | B-ALL | |
| 10q21.2 | ARID5B | 1.91 | B-ALL | (99) |
| 10p12.2 | PIP4K2A | 1.25 | B-ALL | (100) |
| 10p14 | GATA3 | 3.85 | B-ALL (Ph-like) | (101) |
| 9p21.3 | CDKN2A | 2.99 | B-ALL and T-ALL | (102) |
| 9p21.3 | CDKN2B | 1.72 | B-ALL | (103) |
| 10q26.13 | LHPP | 1.21 | B-ALL | (104) |
| 12q23.1 | ELK3 | 1.19 | B-ALL | |
| 2q22.3 | RPL6P5 | 2.14 | B-ALL (ETV6-RUNX1 positive) | (105) |
| 17q21.1 | IKZF3 | 1.18 | B-ALL and T-ALL | (106) |
| 7p15.3 | SP4 | 1.2 | B-ALL and T-ALL | |
| 10p12.31 | BMI1 | 1.27 | ALL (not specified) | (107) |
| 21q22.2 | ERG | 1.56 | B-ALL | (108) |
| 6q23 | MYB/HBS1L | 1.27 | ALL (not specified) | (109) |
| 10q21 | TET1 | 1.15 | ALL (not specified) | |
| 10q21 | NRBF2/JMJD1C | 1.2 | ALL (not specified) |
| Region . | Nearest gene . | Effect size . | ALL (subtype) . | Reference . |
|---|---|---|---|---|
| 5q31.1 | C5orf56 | 1.29 | B-ALL (high-hyperdiploidy) | (97) |
| 6p21.31 | BAK1 | 1.3 | B-ALL (high-hyperdiploidy) | |
| 17q21.32 | IGF2BP1 | 1.33 | B-ALL (ETV6-RUNX1 positive) | |
| 9q21.3 | TLE1 | 1.52 | B-ALL | |
| 7p12.2 | IKZF1 | 1.69 | B-ALL | (98) |
| 10q21.2 | ARID5B | 1.65 | B-ALL (hyperdiploid) | |
| 14q11.2 | CEBPE | 1.34 | B-ALL | |
| 10q21.2 | ARID5B | 1.91 | B-ALL | (99) |
| 10p12.2 | PIP4K2A | 1.25 | B-ALL | (100) |
| 10p14 | GATA3 | 3.85 | B-ALL (Ph-like) | (101) |
| 9p21.3 | CDKN2A | 2.99 | B-ALL and T-ALL | (102) |
| 9p21.3 | CDKN2B | 1.72 | B-ALL | (103) |
| 10q26.13 | LHPP | 1.21 | B-ALL | (104) |
| 12q23.1 | ELK3 | 1.19 | B-ALL | |
| 2q22.3 | RPL6P5 | 2.14 | B-ALL (ETV6-RUNX1 positive) | (105) |
| 17q21.1 | IKZF3 | 1.18 | B-ALL and T-ALL | (106) |
| 7p15.3 | SP4 | 1.2 | B-ALL and T-ALL | |
| 10p12.31 | BMI1 | 1.27 | ALL (not specified) | (107) |
| 21q22.2 | ERG | 1.56 | B-ALL | (108) |
| 6q23 | MYB/HBS1L | 1.27 | ALL (not specified) | (109) |
| 10q21 | TET1 | 1.15 | ALL (not specified) | |
| 10q21 | NRBF2/JMJD1C | 1.2 | ALL (not specified) |