Table 2. Strain mechanics parameters... | Rockefeller University Press

Table 2.

Strain mechanics parameters

	DMSO	DN Low	DN High	OM Low	OM High
Δ HR (bpm)	1.6 ± 3.3	−6 ± 5	−18 ± 9	−5 ± 7	−11 ± 5
Δ Pk. SRS (%)	−3.2 ± 1.5	9.7 ± 1.4^{^a}	18.4 ± 1.7^{^a}^,^{^b}	6.4 ± 1.9^{^a}	13.2 ± 1.2^{^a}^,^{^b}
Δ T2P SRS (% CC)	0.8 ± 1.1	1.2 ± 1.1	6.9 ± 1.1^{^a}^,^{^b}	0.6 ± 0.8	11.6 ± 1.2^{^a}^,^{^b}^,^{^c}
Δ Pk. SRSR (1/s)	0.3 ± 0.5	0.73 ± 0.25	−0.5 ± 0.6	0.25 ± 0.30	−1.57 ± 0.32^{^a}^,^{^b}
Δ T2P SRSR (% CC)	−0.9 ± 1.5	−1.4 ± 1.5	1.1 ± 1.1	−2.8 ± 1.7	−0.8 ± 1.7
Δ Pk. DRSR (1/s)	0.8 ± 0.4	−1.7 ± 0.6	−4.6 ± 0.5^{^a}^,^{^b}	−0.1 ± 0.7	−4.4 ± 0.9^{^a}^,^{^b}
Δ T2P DRSR (% CC)	0.7 ± 1.0	5.3 ± 1.1	12.8 ± 1.1^{^a}^,^{^b}	2.7 ± 0.7	18.1 ± 1.9^{^a}^,^{^b}^,^{^c}

	DMSO	DN Low	DN High	OM Low	OM High
Δ HR (bpm)	1.6 ± 3.3	−6 ± 5	−18 ± 9	−5 ± 7	−11 ± 5
Δ Pk. SRS (%)	−3.2 ± 1.5	9.7 ± 1.4^a	18.4 ± 1.7^a^,^b	6.4 ± 1.9^a	13.2 ± 1.2^a^,^b
Δ T2P SRS (% CC)	0.8 ± 1.1	1.2 ± 1.1	6.9 ± 1.1^a^,^b	0.6 ± 0.8	11.6 ± 1.2^a^,^b^,^c
Δ Pk. SRSR (1/s)	0.3 ± 0.5	0.73 ± 0.25	−0.5 ± 0.6	0.25 ± 0.30	−1.57 ± 0.32^a^,^b
Δ T2P SRSR (% CC)	−0.9 ± 1.5	−1.4 ± 1.5	1.1 ± 1.1	−2.8 ± 1.7	−0.8 ± 1.7
Δ Pk. DRSR (1/s)	0.8 ± 0.4	−1.7 ± 0.6	−4.6 ± 0.5^a^,^b	−0.1 ± 0.7	−4.4 ± 0.9^a^,^b
Δ T2P DRSR (% CC)	0.7 ± 1.0	5.3 ± 1.1	12.8 ± 1.1^a^,^b	2.7 ± 0.7	18.1 ± 1.9^a^,^b^,^c

Absolute change (∆) in LV strain parameters 1 min after infusion of either vehicle control (DMSO), DN at 3 mg/kg (DN Low), DN at 6 mg/kg (DN High), OM at 0.75 mg/kg (OM Low), or OM at 1.5 mg/kg (OM High). N = 8–10 mice/group.

Significance is defined as P < 0.05 for all comparisons as determined by ANOVA and Tukey’s HSD. HR, heart rate; Pk. SRS, peak systolic radial strain; T2P SRS, time-to-peak systolic radial strain; % CC, percent cardiac cycle; Pk. SRSR, peak systolic radial strain rate; T2P SRSR, time-to-peak systolic radial strain rate; Pk. DRSR, peak diastolic radial strain rate; T2P DRSR, time-to-peak diastolic radial strain rate.

Significant difference when compared to the DMSO group.

Significant difference when compared to the low dose of the same drug.

Significant difference when compared to the corresponding dose of DN.

[ViewLarge]

Sharing Unavailable