Structural and functional parallels between the flushing mechanism and sodium channel fast inactivation
| FI mechanism component | Flush mechanism component |
|---|---|
| IFM | Handle |
| Link to channel closing mechanism | Chain |
| Channel closing mechanism | Plug |
| FI mechanism stage | Flush mechanism stage |
| IFM outside pocket | Handle depressed |
| Sodium ion flow | Water flow |
| IFM enters pocket | Handle returns to position |
| FI mechanism component | Flush mechanism component |
|---|---|
| IFM | Handle |
| Link to channel closing mechanism | Chain |
| Channel closing mechanism | Plug |
| IFM outside pocket | Handle depressed |
| Sodium ion flow | Water flow |
| IFM enters pocket | Handle returns to position |
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