Table 3.

Structural and functional parallels between the flushing mechanism and sodium channel fast inactivation

FI mechanism componentFlush mechanism component
IFM Handle 
Link to channel closing mechanism Chain 
Channel closing mechanism Plug 
FI mechanism stage Flush mechanism stage 
IFM outside pocket Handle depressed 
Sodium ion flow Water flow 
IFM enters pocket Handle returns to position 
FI mechanism componentFlush mechanism component
IFM Handle 
Link to channel closing mechanism Chain 
Channel closing mechanism Plug 
FI mechanism stage Flush mechanism stage 
IFM outside pocket Handle depressed 
Sodium ion flow Water flow 
IFM enters pocket Handle returns to position 
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