Table 1. Resting and active membrane... | Rockefeller University Press

Table 1.

Resting and active membrane properties of WT and Fgf14^−/− hippocampal CA1 pyramidal neurons^{^a}

Cell type	R_in (MΩ)	V_rest (mV)	AP_Thr (mV)	APA (mV)	dV²/dt interval (ms)	Peak dV/dt (mV/ms)	APD₅₀ (ms)
WT CA1
(n = 13; N = 3)	62 ± 7	−67 ± 2	−50 ± 1	106 ± 3	0.16 ± 0.01	459 ± 23	0.84 ± 0.03
Fgf14^−/− CA1
(n = 14; N = 3)	69 ± 4	−68 ± 1	−46 ± 1	107 ± 2	0.09 ± 0.01	573 ± 29	0.71 ± 0.02
P value	0.382	0.291	0.015	0.924	0.006	0.007	<0.001

Cell type	R_in (MΩ)	V_rest (mV)	AP_Thr (mV)	APA (mV)	dV²/dt interval (ms)	Peak dV/dt (mV/ms)	APD₅₀ (ms)
WT CA1
(n = 13; N = 3)	62 ± 7	−67 ± 2	−50 ± 1	106 ± 3	0.16 ± 0.01	459 ± 23	0.84 ± 0.03
Fgf14^−/− CA1
(n = 14; N = 3)	69 ± 4	−68 ± 1	−46 ± 1	107 ± 2	0.09 ± 0.01	573 ± 29	0.71 ± 0.02
P value	0.382	0.291	0.015	0.924	0.006	0.007	<0.001

All data are means ± SEM; n = number of cells; N = number of slices/animals. R_in = input resistance; V_rest = resting membrane potential; AP_Thr = voltage threshold for action potential generation; APA = action potential amplitude; dV²/dt interval = time between the first and second peaks in the second derivative of the voltage (dV²/dt) plot; Peak dV/dt = maximum rate of change of the membrane voltage during the rising phase of the action potential; APD₅₀ = action potential duration at 50% repolarization.

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