Table 1. Eight novel genes, which encode... | Rockefeller University Press

Table 1.

Eight novel genes, which encode proteins with phosphatase activity, are identified to regulate KRAS/PM localization

Protein name	Localization	Target PIs	Ref.
MTMR 2	Perinuclear, cytoplasm	PI 3-phosphatase for PI3P and PI(3,5)P₂	Kim et al. (2003), Cao et al. (2008)
MTMR 3	ER, cytoplasm	PI 3-phosphatase for PI3P and PI(3,5)P₂	Walker et al. (2001), Lorenzo et al. (2005)
MTMR 4	Early and recycling endosomes	PI 3-phosphatase for PI3P	Naughtin et al. (2010), Pham et al. (2018)
MTMR 7	Golgi complex, endosomes, cytoplasm	PI 3-phosphatase for PI3P	Mochizuki and Majerus (2003)
MINPP1	ER	3-Phosphatase for Ins(1,3,4,5,6)pentakisphosphate (InsP5), inositol hexakisphosphate (InsP6), and 2,3-bisphosphoglycerate	Chi et al. (2000), Cho et al. (2008)
TMEM55A	Lysosome, late endosome	PI 4-phosphatase for PI(4,5)P₂	Ungewickell et al. (2005)
INPPL1/SHIP2	Cytoplasm, PM, cytoskeleton, lamellipodia	PI 5-phosphatase for PI(3,4,5)P₃	Taylor et al. (2000), Dyson et al. (2001)
PPP2R5B	Cytoplasm	A component of the serine/threonine-protein phosphatase 2A complex (PP2A). Mediates PP2A dephosphorylation of Akt	McCright et al. (1996), Rodgers et al. (2011)

Protein name	Localization	Target PIs	Ref.
MTMR 2	Perinuclear, cytoplasm	PI 3-phosphatase for PI3P and PI(3,5)P₂	Kim et al. (2003), Cao et al. (2008)
MTMR 3	ER, cytoplasm	PI 3-phosphatase for PI3P and PI(3,5)P₂	Walker et al. (2001), Lorenzo et al. (2005)
MTMR 4	Early and recycling endosomes	PI 3-phosphatase for PI3P	Naughtin et al. (2010), Pham et al. (2018)
MTMR 7	Golgi complex, endosomes, cytoplasm	PI 3-phosphatase for PI3P	Mochizuki and Majerus (2003)
MINPP1	ER	3-Phosphatase for Ins(1,3,4,5,6)pentakisphosphate (InsP5), inositol hexakisphosphate (InsP6), and 2,3-bisphosphoglycerate	Chi et al. (2000), Cho et al. (2008)
TMEM55A	Lysosome, late endosome	PI 4-phosphatase for PI(4,5)P₂	Ungewickell et al. (2005)
INPPL1/SHIP2	Cytoplasm, PM, cytoskeleton, lamellipodia	PI 5-phosphatase for PI(3,4,5)P₃	Taylor et al. (2000), Dyson et al. (2001)
PPP2R5B	Cytoplasm	A component of the serine/threonine-protein phosphatase 2A complex (PP2A). Mediates PP2A dephosphorylation of Akt	McCright et al. (1996), Rodgers et al. (2011)

PI—phosphatidylinositol; Ins—inositol; MTMR—myotubularin-related protein; MINPP1—multiple inositol polyphosphate phosphatase 1; TMEM55A—transmembrane protein 55A; INPPL1—inositol polyphosphate phosphatase like 1; SHIP2—SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase; PPP2R5B—protein phosphatase 2 regulatory subunit β.

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