Table 1. Full blood count and basic... | Rockefeller University Press

Table 1.

Full blood count and basic immunology screening of ATRIP patients (F1Pt and CV1720)

	F1Pt			CV1720
Immunological features	4 years, 5 mo	17 years, 6 mo	19 years, 8 mo	7 years, 11 mo	12 years, 5 mo	13 years, 8 mo	14 years, 4 mo
Peripheral blood count
White blood cell counts (/µl)	10,830 (6,000–15,000)	1,850 (4,300–9,640)	3,060 (4,300–9,640)	5,100 (5,000–15,500)	3,200 (4,500–13,000)	3,500 (4,500–13,000)	4,500 (4,500–13,000)
Platelets (×10³/µl)	311 (229–533)	87 (175–343)	194 (175–343)	279 (140–400)	218 (140–400)	199 (140–400)	190 (140–400)
Hemoglobin (g/dl)	12.1 (11.7–15.1)	7.4 (11.7–15.1)	13.4 (11.7–15.1)	13.9 (11.5–14.5)	14.0 (13.0–18.0)	16.0 (13.0–18.0)	15.0 (13.0–18.0)
Lymphocytes (/µl)	1,191 (4,000–10,000)	1,308 (1,230–3,420)	1,050 (1,230–3,420)	1,870 (1,500–6,500)	1,430 (1,500–6,000)	1,190 (1,500–6,000)	1,830 (1,500–6,000)
Neutrophils (/µl)	7,256 (1,500–7,500)	250 (1,930–5,780)	1,280 (1,930–5,780)	2,760 (1,500–8,000)	1,410 (1,800–8,000)	1,820 (1,800–8,000)	2,090 (1,800–8,000)
Monocytes (/µl)	866 (400–1,200)	117 (260–780)	410 (260–780)	350 (200–800)	230 (200–800)	420 (200–800)	330 (200–800)
Eosinophils (/µl)	106 (200–600)	161 (30–370)	260 (30–370)	100 (40–400)	70 (40–400)	70 (40–400)	180 (40–400)
Basophils (/µl)	217 (10–100)	0 (20–80)	40 (20–80)	40 (20–100)	30 (20–100)	0 (20–100)	20 (20–100)
Lymphocyte subsets
T cells (CD3⁺) (/µl)	834 (900–4,500)	1,070 (700–2,100)	1,090 (700–2,100)	N/A	N/A	N/A	1,060 (1,000–2,200)
Helper T cells (CD4⁺) (/µl)	262 (500–2,400)	551 (300–1,400)	413 (300–1,400)	N/A	N/A	N/A	710 (530–1,300)
Cytotoxic T cells (CD8⁺) (/µl) (CD8⁺)	524 (300–1,600)	492 (200–1,200)	639 (200–1,200)	N/A	N/A	N/A	277 (330–920)
B cells (CD19⁺) (/µl)	155 (200–2,100)	139 (100–500)	16 (100–500)	N/A	N/A	N/A	480 (110–570)
NK cells (CD56⁺/CD16⁺) (/µl)	N/A	58.9 (90–600)	53.5 (90–600)	N/A	N/A	N/A	150 (70–480)
Immunoglobulin levels
IgM (g/liter)	2.2 (0.27–0.63)	1.51 (0.4–2.48)	0.31 (0.4–2.48)^{^a}	N/A	N/A	N/A	N/A
IgA (g/liter)	1.4 (0.5–1.24)	1.43 (0.71–3.65)	0.46 (0.71–3.65)^{^a}	N/A	N/A	N/A	N/A
Total IgG (g/liter)	21.4 (4.7–9.3)	15.0 (7.0–16.0)	11.3 (7.0–16.0)	N/A	N/A	N/A	N/A
IgG2 (g/liter)	0.28 (0.72–3.4)	1.79 (1.06–6.1)^{^b}	2.47 (1.5–6.4)^{^b}	N/A	N/A	N/A	N/A

	F1Pt			CV1720
Immunological features	4 years, 5 mo	17 years, 6 mo	19 years, 8 mo	7 years, 11 mo	12 years, 5 mo	13 years, 8 mo	14 years, 4 mo
Peripheral blood count
White blood cell counts (/µl)	10,830 (6,000–15,000)	1,850 (4,300–9,640)	3,060 (4,300–9,640)	5,100 (5,000–15,500)	3,200 (4,500–13,000)	3,500 (4,500–13,000)	4,500 (4,500–13,000)
Platelets (×10³/µl)	311 (229–533)	87 (175–343)	194 (175–343)	279 (140–400)	218 (140–400)	199 (140–400)	190 (140–400)
Hemoglobin (g/dl)	12.1 (11.7–15.1)	7.4 (11.7–15.1)	13.4 (11.7–15.1)	13.9 (11.5–14.5)	14.0 (13.0–18.0)	16.0 (13.0–18.0)	15.0 (13.0–18.0)
Lymphocytes (/µl)	1,191 (4,000–10,000)	1,308 (1,230–3,420)	1,050 (1,230–3,420)	1,870 (1,500–6,500)	1,430 (1,500–6,000)	1,190 (1,500–6,000)	1,830 (1,500–6,000)
Neutrophils (/µl)	7,256 (1,500–7,500)	250 (1,930–5,780)	1,280 (1,930–5,780)	2,760 (1,500–8,000)	1,410 (1,800–8,000)	1,820 (1,800–8,000)	2,090 (1,800–8,000)
Monocytes (/µl)	866 (400–1,200)	117 (260–780)	410 (260–780)	350 (200–800)	230 (200–800)	420 (200–800)	330 (200–800)
Eosinophils (/µl)	106 (200–600)	161 (30–370)	260 (30–370)	100 (40–400)	70 (40–400)	70 (40–400)	180 (40–400)
Basophils (/µl)	217 (10–100)	0 (20–80)	40 (20–80)	40 (20–100)	30 (20–100)	0 (20–100)	20 (20–100)
Lymphocyte subsets
T cells (CD3⁺) (/µl)	834 (900–4,500)	1,070 (700–2,100)	1,090 (700–2,100)	N/A	N/A	N/A	1,060 (1,000–2,200)
Helper T cells (CD4⁺) (/µl)	262 (500–2,400)	551 (300–1,400)	413 (300–1,400)	N/A	N/A	N/A	710 (530–1,300)
Cytotoxic T cells (CD8⁺) (/µl) (CD8⁺)	524 (300–1,600)	492 (200–1,200)	639 (200–1,200)	N/A	N/A	N/A	277 (330–920)
B cells (CD19⁺) (/µl)	155 (200–2,100)	139 (100–500)	16 (100–500)	N/A	N/A	N/A	480 (110–570)
NK cells (CD56⁺/CD16⁺) (/µl)	N/A	58.9 (90–600)	53.5 (90–600)	N/A	N/A	N/A	150 (70–480)
Immunoglobulin levels
IgM (g/liter)	2.2 (0.27–0.63)	1.51 (0.4–2.48)	0.31 (0.4–2.48)^a	N/A	N/A	N/A	N/A
IgA (g/liter)	1.4 (0.5–1.24)	1.43 (0.71–3.65)	0.46 (0.71–3.65)^a	N/A	N/A	N/A	N/A
Total IgG (g/liter)	21.4 (4.7–9.3)	15.0 (7.0–16.0)	11.3 (7.0–16.0)	N/A	N/A	N/A	N/A
IgG2 (g/liter)	0.28 (0.72–3.4)	1.79 (1.06–6.1)^b	2.47 (1.5–6.4)^b	N/A	N/A	N/A	N/A

In case of F1Pt, the time points represent data prior to immunoglobulin treatment (age 4 years, 5 mo), before anti-CD20 mAb treatment (age 17 years, 6 mo), and after anti-CD20 mAb treatment (age 19 years, 8 mo). Bold and italic text signify reduced and elevated values, respectively, in comparison to age-matched reference values enclosed within brackets.

After anti-CD20 mAb treatment.

Under immunoglobulin replacement therapy.

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