Table 4. Summary of effect of altering... | Rockefeller University Press

Table 4.

Summary of effect of altering RU–RU cooperative coefficients u₂ and z₂ using ensemble parameter set 8

Murine LV: α = 0.9996, $\bar{α} = 0.8897$ ⁠, β = 0.9466, and $\bar{β} = 0.1376$
u₁		1.0054				1.0054				1.0054				1.0054				1.0054				1.0054
u₂		2.2659				4.0				7.0				10.0				2.2659				2.2659
z₁		1.0047				1.0047				1.0047				1.0047				1.0047				1.0047
z₂		1.0118				1.0118				1.0118				1.0118				1.50				2.00
V		1.0067				1.0067				1.0067				1.0067				1.0067				1.0067
W		1.0463				1.0463				1.0463				1.0463				1.0463				1.0463
pCa		6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5
K		4.13e-6		7.66e-6		1.48e-5		2.15e-5		5.42e-5		6.31e-5		1.15e-4		1.25e-4		5.57e-6		1.11e-5		9.85e-6		1.60e-5
N		0.8563		0.8654		0.8620		0.8659		0.8648		0.8661		0.8655		0.8661		1.1880		1.4687		2.1035		2.6516
B		0.4774		0.0367		0.2020		0.0131		0.0642		0.0046		0.0312		0.0023		0.3709		0.0196		0.1999		0.0093
C		0.2796		0.5129		0.4256		0.5253		0.4984		0.5298		0.5158		0.5310		0.2867		0.3972		0.2590		0.2376
M1		0.1665		0.3085		0.2551		0.3161		0.2996		0.3189		0.3103		0.3196		0.2346		0.3994		0.3707		0.4910
M2		0.0765		0.1419		0.1173		0.1455		0.1378		0.1467		0.1428		0.1471		0.1079		0.1838		0.1705		0.2260
Ktr		3.1937		36.1580		1.4919		35.2720		2.2195		35.1960		3.2629		35.4490		1.3378		31.4560		0.6910		29.7690
Rel ktr		0.0883		1.0		0.0423		1.0		0.0631		1.0		0.0920		1.0		0.0425		1.0		0.0232		1.0
Porcine LV: α = 1, $\bar{α} = 0.8296$ ⁠, β = 1, and $\bar{β} = 1$
u₁	1.1055				1.1055				1.1055				1.1055				1.1055				1.1055
u₂	17.082				16.0				13.0				10.0				17.082				17.082
z₁	1.0001				1.0001				1.0001				1.0001				1.0001				1.0001
z₂	1.0				1.0				1.0				1.0				1.50				2.00
v	1.0374				1.0374				1.0374				1.0374				1.0374				1.0374
w	1.0				1.0				1.0				1.0				1.0				1.0
pCa	6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5
K	0.0203		0.3312		0.0190		0.2957		0.0064		0.0897		0.0058		0.0613		0.0211		0.6670		0.0220		2.5188
N	0.1314		0.1315		0.1314		0.1315		0.1314		0.1315		0.1314		0.1315		0.1361		0.2033		0.1450		0.4776
B	0.8998		0.0339		0.9055		0.0377		0.9179		0.0530		0.9268		0.0796		0.8954		0.0155		0.8910		0.0032
C	0.0809		0.7794		0.0762		0.7763		0.0662		0.7640		0.0591		0.7425		0.0838		0.7184		0.0868		0.5332
M₁	0.0106		0.1024		0.0100		0.1020		0.0087		0.1000		0.0078		0.0976		0.0114		0.1459		0.0122		0.2543
M₂	0.0088		0.0843		0.0082		0.0840		0.0072		0.0827		0.0064		0.0803		0.0094		0.1202		0.0100		0.2094
ktr	2.2918		3.3452		2.3927		3.3289		2.6257		3.2702		2.8114		3.1842		2.1604		2.9306		2.0321		2.2114
Rel ktr	0.6851		1.0		0.7188		1.0		0.8029		1.0		0.8829		1.0		0.7372		1.0		0.9189		1.0

Murine LV: α = 0.9996, $\bar{α} = 0.8897$ ⁠, β = 0.9466, and $\bar{β} = 0.1376$
u₁		1.0054				1.0054				1.0054				1.0054				1.0054				1.0054
u₂		2.2659				4.0				7.0				10.0				2.2659				2.2659
z₁		1.0047				1.0047				1.0047				1.0047				1.0047				1.0047
z₂		1.0118				1.0118				1.0118				1.0118				1.50				2.00
V		1.0067				1.0067				1.0067				1.0067				1.0067				1.0067
W		1.0463				1.0463				1.0463				1.0463				1.0463				1.0463
pCa		6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5
K		4.13e-6		7.66e-6		1.48e-5		2.15e-5		5.42e-5		6.31e-5		1.15e-4		1.25e-4		5.57e-6		1.11e-5		9.85e-6		1.60e-5
N		0.8563		0.8654		0.8620		0.8659		0.8648		0.8661		0.8655		0.8661		1.1880		1.4687		2.1035		2.6516
B		0.4774		0.0367		0.2020		0.0131		0.0642		0.0046		0.0312		0.0023		0.3709		0.0196		0.1999		0.0093
C		0.2796		0.5129		0.4256		0.5253		0.4984		0.5298		0.5158		0.5310		0.2867		0.3972		0.2590		0.2376
M1		0.1665		0.3085		0.2551		0.3161		0.2996		0.3189		0.3103		0.3196		0.2346		0.3994		0.3707		0.4910
M2		0.0765		0.1419		0.1173		0.1455		0.1378		0.1467		0.1428		0.1471		0.1079		0.1838		0.1705		0.2260
Ktr		3.1937		36.1580		1.4919		35.2720		2.2195		35.1960		3.2629		35.4490		1.3378		31.4560		0.6910		29.7690
Rel ktr		0.0883		1.0		0.0423		1.0		0.0631		1.0		0.0920		1.0		0.0425		1.0		0.0232		1.0
Porcine LV: α = 1, $\bar{α} = 0.8296$ ⁠, β = 1, and $\bar{β} = 1$
u₁	1.1055				1.1055				1.1055				1.1055				1.1055				1.1055
u₂	17.082				16.0				13.0				10.0				17.082				17.082
z₁	1.0001				1.0001				1.0001				1.0001				1.0001				1.0001
z₂	1.0				1.0				1.0				1.0				1.50				2.00
v	1.0374				1.0374				1.0374				1.0374				1.0374				1.0374
w	1.0				1.0				1.0				1.0				1.0				1.0
pCa	6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5		6.1		4.5
K	0.0203		0.3312		0.0190		0.2957		0.0064		0.0897		0.0058		0.0613		0.0211		0.6670		0.0220		2.5188
N	0.1314		0.1315		0.1314		0.1315		0.1314		0.1315		0.1314		0.1315		0.1361		0.2033		0.1450		0.4776
B	0.8998		0.0339		0.9055		0.0377		0.9179		0.0530		0.9268		0.0796		0.8954		0.0155		0.8910		0.0032
C	0.0809		0.7794		0.0762		0.7763		0.0662		0.7640		0.0591		0.7425		0.0838		0.7184		0.0868		0.5332
M₁	0.0106		0.1024		0.0100		0.1020		0.0087		0.1000		0.0078		0.0976		0.0114		0.1459		0.0122		0.2543
M₂	0.0088		0.0843		0.0082		0.0840		0.0072		0.0827		0.0064		0.0803		0.0094		0.1202		0.0100		0.2094
ktr	2.2918		3.3452		2.3927		3.3289		2.6257		3.2702		2.8114		3.1842		2.1604		2.9306		2.0321		2.2114
Rel ktr	0.6851		1.0		0.7188		1.0		0.8029		1.0		0.8829		1.0		0.7372		1.0		0.9189		1.0

Summary of computational results for the model fit of ktr-relative force (Table S1). The model is run with parameter set 8 with fitted rate coefficients taken from Table 4. Varying the strength of the RU-RU blocked-to-closed cooperative coefficient u₂ and the closed-to-open cooperative coefficient z₂ are highlighted in bold. The values of B, C, M₁, and M₂ are recorded when the solution of the ODE system Eqs. 2, 3, and 4 reach their equilibrium state. The activation factor (K = k_BC/k_CB) and crossbridge recruitment factor (N = k_CM1/k_M1C) are computed based on these values. Finally, ktr is computed according to the slack-restretch maneuver (Patel et al., 2023).

View Large

This Feature Is Available To Subscribers Only