Fitted parameters for modeling ktr–pCa relationships in murine and porcine permeabilized ventricular myocardium
| . | Murine parameter sets . | Porcine parameter sets . | ||||
|---|---|---|---|---|---|---|
| Parameter | Set 1 | Set 2 | Set 8 | Set 1 | Set 2 | Set 8 |
| pCa50 | 5.63 | 5.63 | 5.64 | 5.65 | 5.65 | 5.65 |
| k0BC | 0.0166 | 0.0167 | 0.0 | 0.0 | 0.0 | 24.3511 |
| kCa2+BC | 0.4370 | 1.9370 | 1.9453 | 208.4857 | 243.0357 | 243.5360 |
| k0CB | 2.3633 | 2.3633 | 2.3617 | 5,907.6526 | 1,694.7526 | 1,592.7530 |
| kCa2+CB | 0.3979 | 0.3979 | 0.3939 | 246.3005 | 0.0 | 117.5183 |
| f0CM1 | 72.6072 | 43.0072 | 42.9689 | 103.8109 | 91.0080 | 90.9918 |
| f0M1C | 44.2949 | 50.2949 | 50.2944 | 157.6488 | 691.6738 | 691.7920 |
| kM1M2 | 50.6703 | 39.5703 | 42.5863 | 14.6009 | 3.2005 | 2.6762 |
| kM2M1 | 53.5794 | 47.3794 | 44.7155 | 1.6748 | 2.5001 | 2.5561 |
| kM2C | 55.7214 | 47.2714 | 47.8151 | 0.0367 | 0.7366 | 0.6945 |
| u1 | 1.0 | 1.0 | 1.0054 | 1.0 | 1.0 | 1.1055 |
| u2 | 1.0 | 2.2208 | 2.2659 | 1.0 | 15.098 | 17.0820 |
| z1 | 1.0 | 1.0 | 1.0047 | 1.0 | 1.0 | 1.0001 |
| z2 | 1.0 | 1.0 | 1.0118 | 1.0 | 1.1346 | 1.0 |
| V | 1.0 | 1.0 | 1.0067 | 1.0 | 1.0 | 1.0374 |
| W | 1.0 | 1.0 | 1.0463 | 1.0 | 1.0 | 1.0 |
| Α | 1.0 | 1.0 | 0.9996 | 1.0 | 1.0 | 1.0 |
| Α | 1.0 | 1.0 | 0.8897 | 1.0 | 1.0 | 0.8296 |
| Β | 1.0 | 1.0 | 0.9466 | 1.0 | 1.0 | 1.0 |
| Β | 1.0 | 1.0 | 0.1376 | 1.0 | 1.0 | 1.0 |
| RMSE | 3.7580 | 1.0501 | 1.1072 | 1.3499 | 0.2800 | 0.2696 |
| . | Murine parameter sets . | Porcine parameter sets . | ||||
|---|---|---|---|---|---|---|
| Parameter | Set 1 | Set 2 | Set 8 | Set 1 | Set 2 | Set 8 |
| pCa50 | 5.63 | 5.63 | 5.64 | 5.65 | 5.65 | 5.65 |
| k0BC | 0.0166 | 0.0167 | 0.0 | 0.0 | 0.0 | 24.3511 |
| kCa2+BC | 0.4370 | 1.9370 | 1.9453 | 208.4857 | 243.0357 | 243.5360 |
| k0CB | 2.3633 | 2.3633 | 2.3617 | 5,907.6526 | 1,694.7526 | 1,592.7530 |
| kCa2+CB | 0.3979 | 0.3979 | 0.3939 | 246.3005 | 0.0 | 117.5183 |
| f0CM1 | 72.6072 | 43.0072 | 42.9689 | 103.8109 | 91.0080 | 90.9918 |
| f0M1C | 44.2949 | 50.2949 | 50.2944 | 157.6488 | 691.6738 | 691.7920 |
| kM1M2 | 50.6703 | 39.5703 | 42.5863 | 14.6009 | 3.2005 | 2.6762 |
| kM2M1 | 53.5794 | 47.3794 | 44.7155 | 1.6748 | 2.5001 | 2.5561 |
| kM2C | 55.7214 | 47.2714 | 47.8151 | 0.0367 | 0.7366 | 0.6945 |
| u1 | 1.0 | 1.0 | 1.0054 | 1.0 | 1.0 | 1.1055 |
| u2 | 1.0 | 2.2208 | 2.2659 | 1.0 | 15.098 | 17.0820 |
| z1 | 1.0 | 1.0 | 1.0047 | 1.0 | 1.0 | 1.0001 |
| z2 | 1.0 | 1.0 | 1.0118 | 1.0 | 1.1346 | 1.0 |
| V | 1.0 | 1.0 | 1.0067 | 1.0 | 1.0 | 1.0374 |
| W | 1.0 | 1.0 | 1.0463 | 1.0 | 1.0 | 1.0 |
| Α | 1.0 | 1.0 | 0.9996 | 1.0 | 1.0 | 1.0 |
| Α | 1.0 | 1.0 | 0.8897 | 1.0 | 1.0 | 0.8296 |
| Β | 1.0 | 1.0 | 0.9466 | 1.0 | 1.0 | 1.0 |
| Β | 1.0 | 1.0 | 0.1376 | 1.0 | 1.0 | 1.0 |
| RMSE | 3.7580 | 1.0501 | 1.1072 | 1.3499 | 0.2800 | 0.2696 |
Fitted parameters for ktr–pCa relationships in murine- and porcine-permeabilized myocardium using parameter set 1 (no near-neighbor cooperative interactions), parameter set 2 (describing the unitary effect of the RU–RU cooperative interaction), and parameter set 8 (describing the ensemble effects of RU–RU, XB–XB, and XB–RU cooperative interactions). RMSE, root mean squared error.