Table 2. Descriptive statistics of... | Rockefeller University Press

Table 2.

Descriptive statistics of parameters obtained from fitting voltage dependence of activation and SSFI with the Boltzmann equation

	Voltage dependence of activation			Voltage dependence of SSFI				Intersection of activation and SSFI Boltzmann fit curves (mV)	Window current (AUC in mV)	n
	V50_act (mV)	k_act (1/mv)	n	V50_inact (mV)	k_inact (1/mV)	Fraction of channels remaining open after SSFI (%)	n		Window current (AUC in mV)	n
Na_v1.1	−28.9 ± 4.3	8.3 ± 1.1	27	−74.3 ± 5.0	−5.6 ± 1.1	4.3 ± 5.5	27	−56.1 ± 4.6	1.398 ± 1.054	27
Na_v1.2	−29.2 ± 5.6	8.0 ± 1.0	27	−77.9 ± 6.0	−5.8 ± 0.9	3.3 ± 4.5	27	−57.7 ± 5.6	1.073 ± 0.861	27
Na_v1.3	−29.5 ± 4.9	7.8 ± 0.9	27	−76.2 ± 5.9	−6.7 ± 0.7	2.1 ± 3.5	27	−54.7 ± 4.3	0.989 ± 0.661	27
Na_v1.5	−53.3 ± 3.5	7.8 ± 0.7	27	−104.5 ± 5.7	−5.6 ± 0.7	5.9 ± 5.7	27	−83.1 ± 4.6	1.484 ± 1.156	27
Na_v1.6	−33.8 ± 4.2	7.3 ± 0.5	27	−77.9 ± 5.2	−6.9 ± 1.4	5.0 ± 3.3	27	−56.6 ± 4.7	1.598 ± 0.608	27
Na_v1.7	−33.3 ± 5.6	7.9 ± 0.8	27	−84.9 ± 6.3	−6.6 ± 1.3	5.5 ± 6.2	27	−61.6 ± 5.6	1.533 ± 1.195	27
Na_v1.8	−3.1 ± 4.5	11.8 ± 0.9	25	−66.6 ± 5.4	−9.3 ± 1.4	7.1 ± 5.5	26	−38.9 ± 5.1	2.401 ± 1.079	25
Na_v1.9^{^a}	−52.3 ± 9.8	11.0 ± 3.2	24	−68.9 ± 10.3	−12.2 ± 4.9	22.4 ± 9.8	17	−61.0 ± 6.3	12.952 ± 4.114	15

	Voltage dependence of activation			Voltage dependence of SSFI				Intersection of activation and SSFI Boltzmann fit curves (mV)	Window current (AUC in mV)	n
	V50_act (mV)	k_act (1/mv)	n	V50_inact (mV)	k_inact (1/mV)	Fraction of channels remaining open after SSFI (%)	n		Window current (AUC in mV)	n
Na_v1.1	−28.9 ± 4.3	8.3 ± 1.1	27	−74.3 ± 5.0	−5.6 ± 1.1	4.3 ± 5.5	27	−56.1 ± 4.6	1.398 ± 1.054	27
Na_v1.2	−29.2 ± 5.6	8.0 ± 1.0	27	−77.9 ± 6.0	−5.8 ± 0.9	3.3 ± 4.5	27	−57.7 ± 5.6	1.073 ± 0.861	27
Na_v1.3	−29.5 ± 4.9	7.8 ± 0.9	27	−76.2 ± 5.9	−6.7 ± 0.7	2.1 ± 3.5	27	−54.7 ± 4.3	0.989 ± 0.661	27
Na_v1.5	−53.3 ± 3.5	7.8 ± 0.7	27	−104.5 ± 5.7	−5.6 ± 0.7	5.9 ± 5.7	27	−83.1 ± 4.6	1.484 ± 1.156	27
Na_v1.6	−33.8 ± 4.2	7.3 ± 0.5	27	−77.9 ± 5.2	−6.9 ± 1.4	5.0 ± 3.3	27	−56.6 ± 4.7	1.598 ± 0.608	27
Na_v1.7	−33.3 ± 5.6	7.9 ± 0.8	27	−84.9 ± 6.3	−6.6 ± 1.3	5.5 ± 6.2	27	−61.6 ± 5.6	1.533 ± 1.195	27
Na_v1.8	−3.1 ± 4.5	11.8 ± 0.9	25	−66.6 ± 5.4	−9.3 ± 1.4	7.1 ± 5.5	26	−38.9 ± 5.1	2.401 ± 1.079	25
Na_v1.9^{^a}	−52.3 ± 9.8	11.0 ± 3.2	24	−68.9 ± 10.3	−12.2 ± 4.9	22.4 ± 9.8	17	−61.0 ± 6.3	12.952 ± 4.114	15

Data are shown as mean ± SD.

Na_v1.9 Boltzmann values were derived from pooled previously published data from Leipold et al. (2013) and Leipold et al. (2015).