Properties of the pre-recorded APs used as voltage commands
| . | AP1 . | AP2 . | AP3 . |
|---|---|---|---|
| Average resting membrane potential (mV) | −76.5 | −71.9 | −67.4 |
| AP threshold voltage (mV) | −60.1 | −61.2 | −41 |
| Maximum AP voltage (mV) | 10 | 11.2 | 59.3 |
| Voltage amplitude of AP (mV) | 86.5 | 83.1 | 126.7 |
| Minimum voltage of after hyperpolarization (mV) | −71.6 | −67.7 | −59.7 |
| AP half width (ms) | 3.6 | 2.4 | 3.8 |
| Time to AP peak (ms) | 99.6 | 14.6 | 18 |
| Subthreshold slope (mV/ms) | 0.21 | 1.39 | 1.84 |
| Upstroke slope (mV/ms) | 3.31 | 10.64 | 27.1 |
| . | AP1 . | AP2 . | AP3 . |
|---|---|---|---|
| Average resting membrane potential (mV) | −76.5 | −71.9 | −67.4 |
| AP threshold voltage (mV) | −60.1 | −61.2 | −41 |
| Maximum AP voltage (mV) | 10 | 11.2 | 59.3 |
| Voltage amplitude of AP (mV) | 86.5 | 83.1 | 126.7 |
| Minimum voltage of after hyperpolarization (mV) | −71.6 | −67.7 | −59.7 |
| AP half width (ms) | 3.6 | 2.4 | 3.8 |
| Time to AP peak (ms) | 99.6 | 14.6 | 18 |
| Subthreshold slope (mV/ms) | 0.21 | 1.39 | 1.84 |
| Upstroke slope (mV/ms) | 3.31 | 10.64 | 27.1 |
Data were gathered from current-clamp measurements of iPSC-derived nociceptors using the Igor Pro software.