Impact of sustained depolarization on additional passive and active electrophysiological properties of human DRG neurons, related to Fig. 5
| . | Capacitance (pf) . | RMP (mV) . | AP amplitude (mV) . | AP overshoot (mV) . | AP rise (ms) . |
|---|---|---|---|---|---|
| Control (n = 36) | 123 ± 11 | −58 ± 1 | 76 ± 1 | 60 ± 1 | 0.53 ± 0.04 |
| KCl (n = 34) | 118 ± 13 | −60 ± 1 | 72 ± 3 | 52 ± 2a | 0.52 ± 0.05 |
| Control + 24 h recovery (n = 27) | 120 ± 8 | −60 ± 1 | 77 ± 1 | 59 ± 1 | 0.47 ± 0.04 |
| KCl +24 h recovery (n = 28) | 131 ± 10 | −58 ± 1 | 73 ± 2 | 59 ± 2a | 0.49 ± 0.03 |
| . | Capacitance (pf) . | RMP (mV) . | AP amplitude (mV) . | AP overshoot (mV) . | AP rise (ms) . |
|---|---|---|---|---|---|
| Control (n = 36) | 123 ± 11 | −58 ± 1 | 76 ± 1 | 60 ± 1 | 0.53 ± 0.04 |
| KCl (n = 34) | 118 ± 13 | −60 ± 1 | 72 ± 3 | 52 ± 2a | 0.52 ± 0.05 |
| Control + 24 h recovery (n = 27) | 120 ± 8 | −60 ± 1 | 77 ± 1 | 59 ± 1 | 0.47 ± 0.04 |
| KCl +24 h recovery (n = 28) | 131 ± 10 | −58 ± 1 | 73 ± 2 | 59 ± 2a | 0.49 ± 0.03 |
AP overshoot was statistically significant when comparing KCl group versus control + 24 h recovery and KCl group versus KCl + 24 h recovery.
P = 0.0357, one-way ANOVA with Tukey’s multiple comparisons. Data are represented as mean ± SEM.