Germline variant strength of association with overall CH and various subtypes
| . | 0–0.25 . | 0.26–0.5 . | 0.6–0.75 . | 0.76–1.0 . | 1.1–1.25 . | 1.26–1.5 . | |
|---|---|---|---|---|---|---|---|
| Overall CHa | ATM | MSI2 | TERTd | CHEK2 | |||
| BCL2L1 | ODF3B | TET2e | |||||
| CD164 | PARP1 | ||||||
| CNTROB | PURB | ||||||
| DLK1 | RUNX1 | ||||||
| DNAH2 | SENP7 | ||||||
| ENPP6 | SETBP1 | ||||||
| GATA2 | SMC4 | ||||||
| GSDMC | STN1 | ||||||
| HLA-C | TERTb | ||||||
| IL12A | TET2c | ||||||
| ITPR2 | TP53 | ||||||
| KPNA4 | TSC22D2 | ||||||
| LY75 | TYMP | ||||||
| LY75-CD302 | ZNF318 | ||||||
| DNMT3A-CH | ABCC5 | MYB | FLT3 | CHEK2f | CHEK2g | ||
| ATM | OBFC | TERT | |||||
| BCL2L1 | PARP1 | ||||||
| CD164 | PURB | ||||||
| CNTROB | RABIF | ||||||
| DNAH2 | SENP7 | ||||||
| GSDMC | SETBP1 | ||||||
| IL12A | SMC4 | ||||||
| ITPR2 | TCL1A | ||||||
| KPNA4 | TET2 | ||||||
| LY75 | TP53 | ||||||
| LY75-CD302 | TSC22D2 | ||||||
| MSI2 | ZNF318 | ||||||
| TET2-CH | ATM | TCL1A | TP53 | ||||
| GATA2 | TERT | ||||||
| THRB | THEM209 | ||||||
| ASXL-CH | CD164 | TCL1A | |||||
| TP53-CH | SEPT3 | ||||||
| JAK2-CH | JAK2 | ||||||
| . | 0–0.25 . | 0.26–0.5 . | 0.6–0.75 . | 0.76–1.0 . | 1.1–1.25 . | 1.26–1.5 . | |
|---|---|---|---|---|---|---|---|
| Overall CHa | ATM | MSI2 | TERTd | CHEK2 | |||
| BCL2L1 | ODF3B | TET2e | |||||
| CD164 | PARP1 | ||||||
| CNTROB | PURB | ||||||
| DLK1 | RUNX1 | ||||||
| DNAH2 | SENP7 | ||||||
| ENPP6 | SETBP1 | ||||||
| GATA2 | SMC4 | ||||||
| GSDMC | STN1 | ||||||
| HLA-C | TERTb | ||||||
| IL12A | TET2c | ||||||
| ITPR2 | TP53 | ||||||
| KPNA4 | TSC22D2 | ||||||
| LY75 | TYMP | ||||||
| LY75-CD302 | ZNF318 | ||||||
| DNMT3A-CH | ABCC5 | MYB | FLT3 | CHEK2f | CHEK2g | ||
| ATM | OBFC | TERT | |||||
| BCL2L1 | PARP1 | ||||||
| CD164 | PURB | ||||||
| CNTROB | RABIF | ||||||
| DNAH2 | SENP7 | ||||||
| GSDMC | SETBP1 | ||||||
| IL12A | SMC4 | ||||||
| ITPR2 | TCL1A | ||||||
| KPNA4 | TET2 | ||||||
| LY75 | TP53 | ||||||
| LY75-CD302 | TSC22D2 | ||||||
| MSI2 | ZNF318 | ||||||
| TET2-CH | ATM | TCL1A | TP53 | ||||
| GATA2 | TERT | ||||||
| THRB | THEM209 | ||||||
| ASXL-CH | CD164 | TCL1A | |||||
| TP53-CH | SEPT3 | ||||||
| JAK2-CH | JAK2 | ||||||
Table displays various the strength of association between multiple germline variant and overall CH as well as various subtypes. This table is adapted from Quiros and Vassiliou (2023).
Data adapted from Bick et al. (2020); Dawoud et al. (2020); Kar et al. (2022); Kessler et al. (2022); Quiros and Vassiliou (2023); Travaglini et al. (2024).
Data adapted from Kessler et al. (2022); Travaglini et al. (2024).
Data adapted from Kessler et al. (2022).
Data adapted from Bick et al. (2020); Dawoud et al. (2020).
Data adapted from Kar et al. (2022).
Data adapted from Kessler et al. (2022).
Data adapted from Travaglini et al. (2024).