Table 1.

List of 100 CB Proteins identified by Coilin-APEX2 enrichment

FunctionProteins enriched in Coilin-APEX2
Cell cycle progression ANLN, ANXA11, BUB3, KIF4A, NCAPD3, NUMA1, ZNF207 
DNA replication and repair ATAD2, POLD1, RFC5, RECQL, RIF1, USP7 
Transcription CDC73, ERCC3, FUBP1, GTF2F2, GTF3C5, HTATSF1, IRF2BP1, MED1, MED14, MED17, POLR2C, SMARCA4, SMARCC1, SSRP1, SUPT5H, SUPT6H, UBR5, ELL, ICE1, ICE2, POLR2A, POLR2B 
Pre-mRNA splicing and cleavage CLP1, CPSF6, DHX38, IK, KHSRP, NUDT21, PPAN, RBM10, SON, SRRM2, EFTUD2, NHP2L1, PRPF3, PRPF4, SART1, SF3A1, SF3B2, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, TARDBP 
snRNA maturation and snRNP assembly COIL, DDX20, SART3, TGS1, TOE1 
rRNA processing and ribosome biogenesis GAR1, GNL3L, GTPBP4, NSA2, TEX10, DKC1, NOLC1, NOP56, NOP58 
Histone mRNA processing LSM11, NPAT 
miRNA processing SRRT 
RNA helicase DDX18 
RNA exosome EXOSC2 
Ribosomal protein RPL13, RPL14, RPL15, RPL24, RPL3, RPL34, RPL7A, RPL8, RPS2, RPS24 
Other AP2A2, ATP6V1A, CSNK2A1, CSNK2B, CYB5R1, HIST1H2AJ, NUP54, OXA1L, PPIL4, SFXN3, SLC25A13, SPCS3, PSME3 

Statistically enriched proteins identified in the Coilin-APEX2 dataset relative to ΔNTD-APEX2 and relative to APEX2-NLS. Proteins are identified by their Gene ID, and Gene IDs in bold represent previously known CB components.

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