Table 1.

Cryo-EM data collection, refinement, and validation statistics

Nap12•H2A-H2B•Kap114•RanGTPNap12•H2A-H2B•Kap114
Consensus map EMD-44151Locally refined map for Nap12•H2A-H2B
EMD-44150
Composite map PDB: 9B3I
EMD-44141
Consensus map EMD-44140Locally refined map for Nap12
•H2A-H2B
EMD-44137
Composite map PDB: 9B3F
EMD-44136
Data collection and processing 
 Magnification (X) 165,000 105,000 
 Voltage (kV) 300 300 
 Electron exposure (e250 52 
 Defocus range (μm) 0.9–2.2 1.5–2.5 
 Pixel size (Å) 0.738 0.83 
 Symmetry imposed C1 C1 
 Initial particle images (no.) 1,381,753 4,314,112 
 Final particle images (no.) 133,516 113,011 
 Map resolution (Å) 2.88 3.97  3.54 5.62  
  FSC threshold 0.143    
Refinement 
 Initial model used (PDB code)   8F1E, 9B3F   AF-P53067-F1, 8F1E, 9B23 
 Model composition       
  Non-hydrogen atoms   14,951   13,451 
  Protein residues   1,854   1,668 
 Mean B factors (Å2      
  Protein/Ligand   112.36/40.96   317.38 
 R.m.s. deviations       
  Bond lengths (Å)   0.006   0.002 
  Bond angles (°)   0.781   0.505 
 CCvolume/mask   0.74/0.73   0.70/0.70 
Validation 
 MolProbity score   1.55   1.46 
 Clashscore   10.80   7.64 
 Poor rotamers (%)   0.24   
 Ramachandran plot       
  Favored (%)   98.20   97.82 
  Allowed (%)   1.80   2.18 
  Disallowed (%)     
 CaBLAM outliers (%)   0.82   1.04 
 EMRinger score   2.45   0.94 
Nap12•H2A-H2B•Kap114•RanGTPNap12•H2A-H2B•Kap114
Consensus map EMD-44151Locally refined map for Nap12•H2A-H2B
EMD-44150
Composite map PDB: 9B3I
EMD-44141
Consensus map EMD-44140Locally refined map for Nap12
•H2A-H2B
EMD-44137
Composite map PDB: 9B3F
EMD-44136
Data collection and processing 
 Magnification (X) 165,000 105,000 
 Voltage (kV) 300 300 
 Electron exposure (e250 52 
 Defocus range (μm) 0.9–2.2 1.5–2.5 
 Pixel size (Å) 0.738 0.83 
 Symmetry imposed C1 C1 
 Initial particle images (no.) 1,381,753 4,314,112 
 Final particle images (no.) 133,516 113,011 
 Map resolution (Å) 2.88 3.97  3.54 5.62  
  FSC threshold 0.143    
Refinement 
 Initial model used (PDB code)   8F1E, 9B3F   AF-P53067-F1, 8F1E, 9B23 
 Model composition       
  Non-hydrogen atoms   14,951   13,451 
  Protein residues   1,854   1,668 
 Mean B factors (Å2      
  Protein/Ligand   112.36/40.96   317.38 
 R.m.s. deviations       
  Bond lengths (Å)   0.006   0.002 
  Bond angles (°)   0.781   0.505 
 CCvolume/mask   0.74/0.73   0.70/0.70 
Validation 
 MolProbity score   1.55   1.46 
 Clashscore   10.80   7.64 
 Poor rotamers (%)   0.24   
 Ramachandran plot       
  Favored (%)   98.20   97.82 
  Allowed (%)   1.80   2.18 
  Disallowed (%)     
 CaBLAM outliers (%)   0.82   1.04 
 EMRinger score   2.45   0.94 

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