Differences between migrasomes and exosomes
| Property . | Migrasome . | Exosome . |
|---|---|---|
| Diameter | ∼500–3,000 nm | ∼30–150 nm |
| Cargoes | Secretory vesicles Damaged mitochondria mRNA, protein, lipid, etc. | DNA mRNA, miRNA, Long non-coding RNA (LncRNA) Protein, lipid, etc. |
| Biogenesis | Migration-dependent ECM-dependent At the junctions or tips of RFs | Migration-independent ECM-independent Multivesicular body |
| Regulators | Sphingomyelin (SM), SM synthase2 (SMS2) Integrins, PI(4,5)P2, PIP5K, Rab35 Tetraspanins, cholesterol, Syt1, etc. | ESCRTs, tetraspanins, ceramide, cholesterol, flotillins Rab7, Rab31, TBC1D2B Rab27, Synaptotagmin-7 Exocyst, etc. |
| Markers | NDST1, PIGK, CPQ, EOGT, etc. | CD9, CD63, TSG101, Syntenin 1, etc. |
| Property . | Migrasome . | Exosome . |
|---|---|---|
| Diameter | ∼500–3,000 nm | ∼30–150 nm |
| Cargoes | Secretory vesicles Damaged mitochondria mRNA, protein, lipid, etc. | DNA mRNA, miRNA, Long non-coding RNA (LncRNA) Protein, lipid, etc. |
| Biogenesis | Migration-dependent ECM-dependent At the junctions or tips of RFs | Migration-independent ECM-independent Multivesicular body |
| Regulators | Sphingomyelin (SM), SM synthase2 (SMS2) Integrins, PI(4,5)P2, PIP5K, Rab35 Tetraspanins, cholesterol, Syt1, etc. | ESCRTs, tetraspanins, ceramide, cholesterol, flotillins Rab7, Rab31, TBC1D2B Rab27, Synaptotagmin-7 Exocyst, etc. |
| Markers | NDST1, PIGK, CPQ, EOGT, etc. | CD9, CD63, TSG101, Syntenin 1, etc. |